Prosecution Insights
Last updated: April 19, 2026
Application No. 16/475,541

USE OF THE CPCR REGULATOR GENE FOR OBTAINING NEW RECOMBINANT STRAINS OF BACILLUS THURINGIENSIS WITH REDUCED SPORULATION CAPACITY

Final Rejection §112
Filed
Jul 02, 2019
Examiner
ZEMAN, ROBERT A
Art Unit
1645
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Institute Of Plant Protection Chinese Academy Of Agricultural Sciences
OA Round
4 (Final)
54%
Grant Probability
Moderate
5-6
OA Rounds
3y 9m
To Grant
82%
With Interview

Examiner Intelligence

Grants 54% of resolved cases
54%
Career Allow Rate
413 granted / 766 resolved
-6.1% vs TC avg
Strong +28% interview lift
Without
With
+27.9%
Interview Lift
resolved cases with interview
Typical timeline
3y 9m
Avg Prosecution
51 currently pending
Career history
817
Total Applications
across all art units

Statute-Specific Performance

§101
4.4%
-35.6% vs TC avg
§103
21.5%
-18.5% vs TC avg
§102
16.6%
-23.4% vs TC avg
§112
40.7%
+0.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 766 resolved cases

Office Action

§112
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION The amendment filed on 9-17-2025 is acknowledged. Claims 6 and 10 have been amended. Claim 7 has been canceled. Claims 1-6, 8 and 10-19 are pending. Claims 1-5 and 11-19 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Claims 6, 8 and 10 are currently under examination. Claim Rejections Withdrawn The rejection of claims 6, 8 and 10 are rejected under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement is withdrawn in light of the amendment thereto. The rejection of claim 6 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being rendered vague and indefinite by the use of the phrase “…at least one gene encoding Cry and/or Cyt toxins” is withdrawn in light of the amendment thereto. The rejection of claim 10 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, for lacking proper antecedent basis for the limitation "genes encoding toxins" in line 2 is withdrawn in light of the amendment thereto. New Grounds of Rejection The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 6, 8 and 10 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 6 is rendered vague and indefinite by the use of the phrase “…at least one gene encoding Cry or Cyt toxins”. It is unclear what is meant to be engendered by said phrase. It is unclear how a given gene can encode for a plurality of toxins. As written, it is impossible to determine the metes and bounds of the claimed invention. It is suggested that the phrase “…at least one gene encoding a Cry or Cyt toxin” be used instead. Claim 10 is rendered vague and indefinite by the use of the phrase “…wherein the genes encoding toxins are selected from the group consisting of cry1, cry2, cry3, cry4, cry5, cry6, cry8, cry9, cry11, cry14, cry21, cyt1 and cyt2 genes”. It is unclear what is meant to be engendered by said phrase as the recited genes encode for a single toxin whereas the independent claim is drawn to genes encoding a plurality of toxins. As written, it is impossible to determine the metes and bounds of the claimed invention. It is suggested that the phrase “…wherein the at least one gene encoding a Cry or Cyt toxin is selected from the group consisting of cry1, cry2, cry3, cry4, cry5, cry6, cry8, cry9, cry11, cry14, cry21, cyt1 and cyt2 genes” Conclusion No claim is allowed. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to ROBERT A ZEMAN whose telephone number is (571)272-0866. The examiner can normally be reached Monday thru Friday; 6:30 am - 3pm EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Vanessa Ford can be reached at 571-272-0857. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ROBERT A ZEMAN/Primary Examiner, Art Unit 1645 January 3, 2026
Read full office action

Prosecution Timeline

Jul 02, 2019
Application Filed
Feb 03, 2023
Non-Final Rejection — §112
Aug 09, 2023
Response Filed
Nov 03, 2023
Final Rejection — §112
Mar 01, 2024
Request for Continued Examination
Mar 08, 2024
Response after Non-Final Action
May 15, 2025
Non-Final Rejection — §112
Sep 17, 2025
Response Filed
Jan 03, 2026
Final Rejection — §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
54%
Grant Probability
82%
With Interview (+27.9%)
3y 9m
Median Time to Grant
High
PTA Risk
Based on 766 resolved cases by this examiner. Grant probability derived from career allow rate.

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