Prosecution Insights
Last updated: April 17, 2026
Application No. 16/991,925

LABYRINTHULOMYCETE STRAINS FOR PRODUCING DOCOSAHEXAENOIC ACID

Non-Final OA §102
Filed
Aug 12, 2020
Examiner
TICHY, JENNIFER M.H.
Art Unit
1653
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Synthetic Genomics, Inc.
OA Round
5 (Non-Final)
65%
Grant Probability
Favorable
5-6
OA Rounds
3y 2m
To Grant
99%
With Interview

Examiner Intelligence

Grants 65% — above average
65%
Career Allow Rate
395 granted / 606 resolved
+5.2% vs TC avg
Strong +34% interview lift
Without
With
+34.4%
Interview Lift
resolved cases with interview
Typical timeline
3y 2m
Avg Prosecution
77 currently pending
Career history
683
Total Applications
across all art units

Statute-Specific Performance

§101
3.7%
-36.3% vs TC avg
§103
36.0%
-4.0% vs TC avg
§102
20.2%
-19.8% vs TC avg
§112
29.1%
-10.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 606 resolved cases

Office Action

§102
DETAILED ACTION The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on 18 June 2024 has been entered. Claims 1, 6, and 7 have been amended. Claim 14 is newly added. Claims 10 and 11, and the species NRRL number 50836 in claim 1, remain withdrawn. It is noted that the species of SEQ ID NO: 10 was elected for examination in claims 6 and 7, and the species of SEQ ID NOs: 9, 11, and 12 were withdrawn. As Applicant has amended claims 6 and 7 to remove the elected species of SEQ ID NO: 10, and as only non-elected species remain (i.e. SEQ ID NOs: 9, 11, and 12) in these claims, claims 6 and 7 are now withdrawn from consideration. Claims 1, 5, and 14 are currently pending and under examination. This application is a Continuation Application of U.S. Patent Application No. 14/720679, filed May 22, 2015, which claims benefit of priority to U.S. Provisional Patent Application No. 62/002107, filed May 22, 2014. Withdrawal of Rejections: The rejection of claims 1 and 5-7 under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement, is withdrawn. The rejection of claims 1 and 5-7 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite, is withdrawn. The rejection of claims 6 and 7 under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form, is withdrawn. New Objections and Rejections: Claim Objections Claim 14 is objected to because of the following informalities: the term “18S r DNA” should instead read “18S rDNA.” Appropriate correction is required. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1, 5, and 14 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Pora et al. (IDS; WO 2012/175027, Published 2012). With regard to claims 1, 5, and 14, Pora et al. teach a mutant Schizochytrium sp. strain identified as 2010-0321, wherein this strain comprises an 18S rDNA sequence having 98% identity to SEQ ID NO: 10 (Abs.; claim 1, 2, 4, 16; see also Sequence Comparison of current SEQ ID NO: 10 to Pora et al. SEQ ID NO: 2- Previously Presented). As currently written, Applicant claims either the mutant Labyrinthulomycete microorganism deposited under NRRL number 50837 produced as claimed, or a derivative strain thereof. A strain derived from NRRL number 50837 is defined in the claims as a strain comprising an 18S rDNA sequence having at least 90% identity, or at least 98% identity, to SEQ ID NO: 10. As Schizochytrium sp. strain 2010-0321 of Pora et al. comprises an 18S rDNA sequence having 98% identity to SEQ ID NO: 10, Schizochytrium sp. strain 2010-0321 is a strain derived from NRRL number 50837 as claimed, as this taught strain comprises an 18S rDNA sequence having 98% identity to SEQ ID NO: 10. As the mutant Schizochytrium sp. strain identified as 2010-0321 comprising an 18S rDNA sequence having 98% identity to SEQ ID NO: 10 of Pora et al. cannot be separated from its properties, the mutant Schizochytrium sp. strain identified as 2010-0321 would necessarily produce a microbial oil comprising at least 35% of total fatty acids as DHA and at least 25% of total fatty acids as myristic acid, as well as produce DHA at a rate of at least 100 mg/L/h, and produce at least 20% more DHA and at least 100% more myristic acid as a percent of total fatty acids than the wild type strain from which it is derived. Conclusion No claims are allowable. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JENNIFER M.H. TICHY whose telephone number is (571)272-3274. The examiner can normally be reached Monday-Thursday, 9:00am-7:00pm ET. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Sharmila G. Landau can be reached on (571)272-0614. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JENNIFER M.H. TICHY/Primary Examiner, Art Unit 1653
Read full office action

Prosecution Timeline

Aug 12, 2020
Application Filed
Mar 25, 2022
Non-Final Rejection — §102
Jun 27, 2022
Response Filed
Oct 11, 2022
Final Rejection — §102
Nov 17, 2022
Response after Non-Final Action
Jan 11, 2023
Request for Continued Examination
Jan 12, 2023
Response after Non-Final Action
May 30, 2023
Non-Final Rejection — §102
Dec 05, 2023
Response Filed
Mar 18, 2024
Final Rejection — §102
Jun 18, 2024
Request for Continued Examination
Jun 18, 2024
Response after Non-Final Action
Aug 22, 2024
Examiner Interview Summary
Aug 22, 2024
Applicant Interview (Telephonic)
Aug 28, 2024
Response after Non-Final Action
Dec 28, 2024
Non-Final Rejection — §102
Jul 12, 2025
Response after Non-Final Action

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
65%
Grant Probability
99%
With Interview (+34.4%)
3y 2m
Median Time to Grant
High
PTA Risk
Based on 606 resolved cases by this examiner. Grant probability derived from career allow rate.

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