Prosecution Insights
Last updated: April 19, 2026
Application No. 17/137,985

BACILLUS AMYLOLIQUEFACIENS AND NEONICOTINOIDS MIXTURES AND METHODS OF USE THEREOF

Final Rejection §103
Filed
Dec 30, 2020
Examiner
PIPIC, ALMA
Art Unit
1617
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Valent U S A LLC
OA Round
8 (Final)
55%
Grant Probability
Moderate
9-10
OA Rounds
3y 1m
To Grant
99%
With Interview

Examiner Intelligence

Grants 55% of resolved cases
55%
Career Allow Rate
380 granted / 696 resolved
-5.4% vs TC avg
Strong +57% interview lift
Without
With
+56.9%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
57 currently pending
Career history
753
Total Applications
across all art units

Statute-Specific Performance

§101
0.7%
-39.3% vs TC avg
§103
40.6%
+0.6% vs TC avg
§102
10.2%
-29.8% vs TC avg
§112
32.2%
-7.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 696 resolved cases

Office Action

§103
*DETAILED ACTION* Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant’s submission filed on November 13, 2025 has been entered. Priority This application claims benefit in provisional application 62/956,706 filed on 01/03/2020. Claim Status Claims 6-22 are pending. Claims 1-5 were canceled. Claims 6, 7, 21, and 22 are examined. Claims 8-20 remain withdrawn. No claims were amended or newly added. Maintained Claim Rejections —35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. Claims 6, 7, 21, and 22 are rejected under 35 U.S.C. 103 as being unpatentable over Jabs (US 2017/0188584 Al Published July 6, 2017). The claims encompass pesticidal mixtures. The teachings of Jabs are related to pesticidal mixtures comprising a Bacillus strain and a pesticide (Title and Abstract). Particular preference is given to mixtures comprising as component 1) B. amyloliquefaciens AP-188 and as component 2) at least one pesticide II selected from pyraclostrobin, azoxystrobin, trifloxystobin; fluxapyroxad, penflufen, sedaxane, fluopyram; ipconazole; oxathiapiprolin, valifenalate; fipronil; imidacloprid; chlorantraniliprole; and cyantraniliprole (page 0185). Specific mixtures encompass an agrochemical composition comprising a fungicidally or insecticidally effective amount of at least one microorganism I and at least one pesticide II. Such an amount can vary in a broad range and is dependent on various factors (paragraph 0224). In the mixtures, the weight ratio of the component 1) and the component 2) generally depends on the properties of the active components used, usually it is in the range of from 1:10,000 to 10,000:1, regularly in the range of from 1:100 to 10,000:1, preferably in the range of from 1:100 to 5,000:1, more preferably in the range of from 1:1 to 1,000:1, even more preferably in the range of from 1:1 to 500:1 and in particular in the range of from 10:1 to 300:1 (paragraph 0258). According to further embodiments of the mixtures and compositions, the weight ratio of component 1) and the component 2) usually is in the range of from 1:1 to 1:1000, often in the range of from 1:1 to 1:100, regularly in the range of from 1:1 to 1:50, and preferably in the range of from 1:1 to 1:20 (paragraph 0261). Regarding claims 7 and 21, it would have been prima facie obvious to a person of ordinary skill in the art at the time of the claimed invention to have formed a pesticidal mixture comprising an effective amount B. amyloliquefaciens and imidocloprid wherein the weight ratio of B. amyloliquefaciens to imidocloprid ranges from 1:1 to 1:1000, with a reasonable expectation of success because Jabs teaches a pesticidal mixture comprising B. amyloliquefaciens as component I and at least one pesticide selected from imidocloprid as component II, where the weight ratio of component I to component II ranges from 1:1 to 1:1000 and where the microorganism and the pesticide are present in a fungicidally or insecticidally effective amount. The claimed ranges of ratios of B. amyloliquefaciens to imidocloprid are obvious because the claimed ranges of “from about 1:177 to about 1:200” and “about 177” are encompassed by the prior art range of from 1:1 to 1:1000. Regarding claims 6 and 22, it would have been further obvious to the skilled artisan to have added at least one suitable auxiliary to pesticidal mixture, with a reasonable expectation of success because Jabs teaches that the composition further comprises at least one auxiliary (paragraph 0138). It would have been obvious to have selected a stabilizer as a suitable auxiliary, with a reasonable expectation of success because Jabs teaches stabilizers as suitable auxiliaries (paragraph 0231). The prior art composition contains the same active agents as claimed and in a range of weight ratios that encompasses the claimed ranges of weight ratios. It would have been reasonable to expect the prior art composition to have the same properties as claimed composition when placed under identical conditions including being capable of controlling tomato spotted wilt virus, absent evidence to the contrary. A composition and its properties are inseparable. Combining prior art elements according to known methods to obtain predictable results supports obviousness. Response to Arguments Applicant’s arguments submitted in the remarks dated April 25, 2025, were fully considered but are not persuasive for the following reasons. The claimed ranges of weight ratios are obvious because they overlap with Jabs’ range of weight ratios. It has been held that in the case where the claimed ranges "overlap or lie inside ranges disclosed by the prior art” a prima facie case of obviousness exists. The examiner acknowledges that the claimed ranges are narrower than Jabs’ range, however that is not sufficient to render the claimed ranges nonobvious over Jabs. The specification was reviewed and there is no evidence that claimed ranges are critical or provide an unexpected property to the claimed composition. Jabs teaches using the microorganism and the pesticide in a fungicidally or insecticidally effective amount. Jabs further teaches using each component in an effective amount and further teaches that the ratios are advantageously chosen so as to produce a synergistic effect (paragraph 0252). A person skilled in the art would have been capable of varying the ratios of the two in the range of 1:1 to 1:1000 in order to arrive at a composition that contains the two in an effective amount, and alternatively to obtain a composition having the two components that produce a synergistic effect. It would have been routine to vary concentrations and ratios of the two components in order to arrive at a composition having fungicidally or insecticidally effective amounts of the components, and alternatively having synergistic amounts of said components. Conclusion No claims are allowed. All claims are identical to or patentably indistinct from, or have unity of invention with claims in the application prior to the entry of the submission under 37 CFR 1.114 (that is, restriction (including a lack of unity of invention) would not be proper) and all claims could have been finally rejected on the grounds and art of record in the next Office action if they had been entered in the application prior to entry under 37 CFR 1.114. Accordingly, THIS ACTION IS MADE FINAL even though it is a first action after the filing of a request for continued examination and the submission under 37 CFR 1.114. See MPEP § 706.07(b). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Alma - Pipic whose telephone number is (571)270-7459. The examiner can normally be reached M-F 9:00am-5:00pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Michael Hartley can be reached on 571-272-0616. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ALMA PIPIC/ Primary Examiner, Art Unit 1617
Read full office action

Prosecution Timeline

Dec 30, 2020
Application Filed
Aug 01, 2022
Non-Final Rejection — §103
Jan 04, 2023
Response Filed
Jan 25, 2023
Final Rejection — §103
Jul 28, 2023
Request for Continued Examination
Jul 30, 2023
Response after Non-Final Action
Aug 06, 2023
Non-Final Rejection — §103
Feb 12, 2024
Response Filed
Feb 13, 2024
Final Rejection — §103
Apr 04, 2024
Request for Continued Examination
Apr 08, 2024
Response after Non-Final Action
Apr 15, 2024
Non-Final Rejection — §103
Oct 16, 2024
Response Filed
Oct 23, 2024
Final Rejection — §103
Apr 28, 2025
Request for Continued Examination
Apr 29, 2025
Response after Non-Final Action
May 15, 2025
Final Rejection — §103
Nov 13, 2025
Request for Continued Examination
Nov 14, 2025
Response after Non-Final Action
Nov 24, 2025
Final Rejection — §103 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

9-10
Expected OA Rounds
55%
Grant Probability
99%
With Interview (+56.9%)
3y 1m
Median Time to Grant
High
PTA Risk
Based on 696 resolved cases by this examiner. Grant probability derived from career allow rate.

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