Prosecution Insights
Last updated: April 19, 2026
Application No. 17/302,597

FLUORESCENT DIAMOND PARTICLES AND METHODS OF FABRICATING THE SAME

Non-Final OA §103
Filed
May 07, 2021
Examiner
GREGORIO, GUINEVER S
Art Unit
1732
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Element Six (Uk) Limited
OA Round
2 (Non-Final)
73%
Grant Probability
Favorable
2-3
OA Rounds
3y 4m
To Grant
91%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allow Rate
600 granted / 825 resolved
+7.7% vs TC avg
Strong +18% interview lift
Without
With
+18.5%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
28 currently pending
Career history
853
Total Applications
across all art units

Statute-Specific Performance

§101
0.6%
-39.4% vs TC avg
§103
57.7%
+17.7% vs TC avg
§102
9.7%
-30.3% vs TC avg
§112
20.0%
-20.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 825 resolved cases

Office Action

§103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Arguments Applicant’s arguments with respect to claim(s) 1-9 and 26-35 have been considered but are moot because the new ground of rejection. Claim Rejections - 35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. Claims 1-9 is/are rejected under 35 U.S.C. 103 as being unpatentable over Curmi et al. (WIPO 2010/102977) in view of Barjon et al. (High quality, large surface area, homoepitaxial MPACVD diamond growth; Diamond & Related Materials 18; 683–697; 2009). Regarding claims 1, 2, 3, 4, 6, 7, and 9, Curmi et al. teaches cubic diamond nanocrystals which maximum size is equal or less to 100 nm obtained by nanomilling fine powder and therefore meets a broad and reasonable interpretation of a diamond powder comprising diamond particles having an average particle size of no more than 20 microns (page 3, lines 5-25). Curmi et al. teaches nitrogen vacancy and diamond nanocrystal consists of carbon comprising 0 to 2000 ppm dopant which therefore overlaps with a vacancy or impurity-vacancy point defect concentration of at least 1 ppm (page 5, lines 15-25). Curmi et al teaches providing diamond powder for milling but does not specify the source of the powder (page 2; page 3, lines 10-20). Barjon et al. teaches two CVD films grown, in identical conditions, one on a substrate face made up of a single <100> growth sector, and the other on a substrate face consisting of several sectors (page 689, paragraph 1). Barjon et al. teaches experiment demonstrates that, when using HPHT substrates, only faces consisting of a single <100> growth sector are suitable for homoepitaxial CVD diamond growth, if one wishes to avoid as much as possible the presence of dislocations during the growth (page 690, paragraph 3; Fig. 16). Barjon et al. teaches the need for careful substrate pre-treatment and selection (including choosing a single-sector face) to minimize defects in the growing films (abstract). It would have been obvious to one of ordinary skill in the art at the time of filing to use the CVD film grown on a substrate face made up of a single <100> growth sector for the diamond powder milling taught by Curmi et al. because it minimizes defects and dislocations. Regarding claim 5, Curmi et al. teaches nitrogen vacancy (page 12, lines 15-30). Regarding claim 8, Curmi et al. teaches labelling a molecule comprising grafting a preceding cubic diamond nanocrystal which meets a broad and reasonable interpretation of comprising one or more organic functional groups bonded to an outer surface of the diamond particles (page 6, lines 5-15). Regarding claims 26-29, Curmi et al. teaches nitrogen vacancy and diamond nanocrystal consists of carbon comprising 0 to 2000 ppm dopant which therefore overlaps with a vacancy or impurity-vacancy point defect concentration of at least 10, 20, 50, 100 ppm (page 5, lines 15-25). Regarding claim 34, Curmi et al. teaches cubic diamond nanocrystals which maximum size is equal or less to 100 nm obtained by nanomilling fine powder and therefore meets a broad and reasonable interpretation of wherein the average particle size of the diamond particles is no more than 200 nanometres (page 3, lines 5-25). Regarding claim 35, Barjon et al. teaches a CVD film grown on a substrate face made up of a single <100> growth sector which meets a broad and reasonable interpretation of wherein the volume of diamond in the powder formed from a single crystal growth sector is greater than 90% (page 689, paragraph 1). Barjon et al. teaches experiment demonstrates that, when using HPHT substrates, only faces consisting of a single <100> growth sector are suitable for homoepitaxial CVD diamond growth, if one wishes to avoid as much as possible the presence of dislocations during the growth (page 690, paragraph 3; Fig. 16). Barjon et al. teaches the need for careful substrate pre-treatment and selection (including choosing a single-sector face) to minimize defects in the growing films (abstract). It would have been obvious to one of ordinary skill in the art at the time of filing to use the CVD film grown on a substrate face made up of a single <100> growth sector for the diamond powder milling taught by Curmi et al. because it minimizes defects and dislocations. Claim(s) 30-33 is/are rejected under 35 U.S.C. 103 as being unpatentable over Curmi et al. in view of Barjon et al. as applied to claim 19 above, and further in view of Wrachtrup et al. (Single Nitrogen Vacancy Centers in Chemical Vapor Deposited Diamond Nanocrystals; Nano Lett., Vol. 7, No. 11, 2007). Curmi et al. teaches cubic diamond nanocrystals which maximum size is equal or less to 100 nm obtained by nanomilling fine powder and therefore meets a broad and reasonable interpretation of a diamond powder comprising diamond particles having an average particle size of no more than 20 microns (page 3, lines 5-25). Curmi et al. teaches nitrogen vacancy and diamond nanocrystal consists of carbon comprising 0 to 2000 ppm dopant which therefore overlaps with a vacancy or impurity-vacancy point defect concentration of at least 1 ppm (page 5, lines 15-25). Curmi et al teaches providing diamond powder for milling but does not specify the source of the powder (page 2; page 3, lines 10-20). Barjon et al. teaches two CVD films grown, in identical conditions, one on a substrate face made up of a single <100> growth sector, and the other on a substrate face consisting of several sectors (page 689, paragraph 1). Barjon et al. teaches experiment demonstrates that, when using HPHT substrates, only faces consisting of a single <100> growth sector are suitable for homoepitaxial CVD diamond growth, if one wishes to avoid as much as possible the presence of dislocations during the growth (page 690, paragraph 3; Fig. 16). Barjon et al. teaches the need for careful substrate pre-treatment and selection (including choosing a single-sector face) to minimize defects in the growing films (abstract). It would have been obvious to one of ordinary skill in the art at the time of filing to use the CVD film grown on a substrate face made up of a single <100> growth sector for the diamond powder milling taught by Curmi et al. because it minimizes defects and dislocations. Curmi et al. in view of Barjon et al. do not teach wherein the particles in the powder have an average vacancy or impurity-vacancy point defect concentration, and a variation about the average vacancy or impurity-vacancy point defect concentration is no more than 40%, 30%, 20%, or 10%. Wrachtrup et al. teaches in quantum information processing the nitrogenvacancy (NV) color center in diamond has been demonstrated to be an efficient source for single photons1,2 and has been used to implement quantum key distribution in free space (page 3433, paragraph 1). Wrachtrup et al. teaches on average a 60-70 nm diameter crystal would be expected to have 0.15-0.2 NV centers which would give an estimated variance for data ranging from 0.15 to 0.2 that is no more than 40%, 30%, 20%, or 10% (page 3435, paragraph 5). It is clear that the NV centers taught by Curmi et al. in view of Barjon et al. would necessarily give a variation about the average vacancy or impurity-vacancy point defect concentration is no more than 40%, 30%, 20%, or 10% (paragraph 36). Claim(s) 1-9, 26-29 and 35 is/are rejected under 35 U.S.C. 103 as being unpatentable over Chang et al. (2008/0118966) in view of Barjon et al. (High quality, large surface area, homoepitaxial MPACVD diamond growth; Diamond & Related Materials 18; 683–697; 2009). Regarding claims 1, 2, and 35 Chang et al. teaches particles have a diameter of 1 nm to 1 mm which overlaps with a diamond powder comprising diamond particles having an average particle size of no more than 20 µm (paragraph 8). As set forth in MPEP 2144.05, in the case where the claimed range “overlap or lie inside ranges disclosed by the prior art”, a prima facie case of obviousness exists, In re Wertheim, 541 F.2d 257, 191 USPQ 90 (CCPA 1976); In re Woodruff, 919 F.2d 1575, 16 USPQ2d 1934 (Fed. Cir. 1990). Chang et al. teaches has 5 ppm to 1000 ppm color centers (e.g., 5 ppm to 500 ppm) wherein the color centers can include negatively charged nitrogen-vacancy defects and neutral nitrogen-vacancy defects which meets a broad and reasonable interpretation of a vacancy or impurity-vacancy point defect concentration of at least 1 ppm (paragraph 11). Chang et al. teaches synthetic type Ib diamond single crystals obtained from Element Six (paragraph 38). It is known in the art that type Ib diamonds contain nitrogen, but the nitrogen atoms are dispersed individually (isolated) rather than in clusters and are formed through HPHT or CVD processes. Barjon et al. teaches two CVD films grown, in identical conditions, one on a substrate face made up of a single <100> growth sector, and the other on a substrate face consisting of several sectors (page 689, paragraph 1). Barjon et al. teaches experiment demonstrates that, when using HPHT substrates, only faces consisting of a single <100> growth sector are suitable for homoepitaxial CVD diamond growth, if one wishes to avoid as much as possible the presence of dislocations during the growth (page 690, paragraph 3; Fig. 16). Barjon et al. teaches the need for careful substrate pre-treatment and selection (including choosing a single-sector face) to minimize defects in the growing films (abstract). It would have been obvious to one of ordinary skill in the art at the time of filing to use the CVD film grown on a substrate face made up of a single <100> growth sector for the diamond powder taught by Chang et al. because it minimizes defects and dislocations. Regarding claim 3, it would have been obvious to one ordinary skill in the art to use known methods such as crushing and/or grinding diamond particles to obtain diamond particles of desired size. Regarding claim 4, Chang et al. teaches has 5 ppm to 1000 ppm color centers (e.g., 5 ppm to 500 ppm) wherein the color centers can include negatively charged nitrogen-vacancy defects and neutral nitrogen-vacancy defects which meets a broad and reasonable interpretation of a vacancy or impurity-vacancy point defect concentration of any one of at least: 5 ppm (paragraph 11). Regarding claim 5, Chang et al. teaches has 5 ppm to 1000 ppm color centers (e.g., 5 ppm to 500 ppm) wherein the color centers can include negatively charged nitrogen-vacancy defects and neutral nitrogen-vacancy defects which meets a broad and reasonable interpretation wherein the impurity- vacancy point defects are selected from any of nitrogen-vacancy point defects and silicon-vacancy point defects (paragraph 11). Regarding claim 6, Chang et al. teaches has 5 ppm to 1000 ppm color centers (e.g., 5 ppm to 500 ppm) wherein the color centers can include negatively charged nitrogen-vacancy defects and neutral nitrogen-vacancy defects which meets a broad and reasonable interpretation of wherein the particles in the powder have an average vacancy or impurity-vacancy point defect concentration, and a variation about the average vacancy or impurity-vacancy point defect concentration is selected from any one of no more than: 50% (paragraph 11). Regarding claim 7, Chang et al. teaches particles have a diameter of 1 nm to 1 mm which overlaps with wherein the average particle size of the diamond particles is selected from any of no more than 500 nanometres (paragraph 8). As set forth in MPEP 2144.05, in the case where the claimed range “overlap or lie inside ranges disclosed by the prior art”, a prima facie case of obviousness exists, In re Wertheim, 541 F.2d 257, 191 USPQ 90 (CCPA 1976); In re Woodruff, 919 F.2d 1575, 16 USPQ2d 1934 (Fed. Cir. 1990). Regarding claim 8, Chang et al. teaches the surface of diamond can be easily functionalized for specific or nonspecific binding with nucleic acids and proteins without affecting its fluorescence properties which meets a broad and reasonable interpretation of further comprising one or more organic functional groups bonded to an outer surface of the diamond particles (paragraph 6). Regarding claim 9, Chang et al. teaches synthetic type Ib diamond single crystals were obtained from Element Six which meets a broad and reasonable interpretation of wherein the volume of diamond in the powder formed from a single crystal growth sector is selected from any of greater than 80% (paragraph 38). Regarding claims 26-29, Chang et al. teaches has 5 ppm to 1000 ppm color centers (e.g., 5 ppm to 500 ppm) wherein the color centers can include negatively charged nitrogen-vacancy defects and neutral nitrogen-vacancy defects which meets the claimed vacancy or impurity-vacancy point defect concentration (paragraph 11). Claim(s) 30-33 is/are rejected under 35 U.S.C. 103 as being unpatentable over Chang et al. in view of Barjon et al. as applied to claim 19 above, and further in view of Wrachtrup et al. (Single Nitrogen Vacancy Centers in Chemical Vapor Deposited Diamond Nanocrystals; Nano Lett., Vol. 7, No. 11, 2007). Chang et al. teaches particles have a diameter of 1 nm to 1 mm which overlaps with a diamond powder comprising diamond particles having an average particle size of no more than 20 µm (paragraph 8). As set forth in MPEP 2144.05, in the case where the claimed range “overlap or lie inside ranges disclosed by the prior art”, a prima facie case of obviousness exists, In re Wertheim, 541 F.2d 257, 191 USPQ 90 (CCPA 1976); In re Woodruff, 919 F.2d 1575, 16 USPQ2d 1934 (Fed. Cir. 1990). Chang et al. teaches has 5 ppm to 1000 ppm color centers (e.g., 5 ppm to 500 ppm) wherein the color centers can include negatively charged nitrogen-vacancy defects and neutral nitrogen-vacancy defects which meets a broad and reasonable interpretation of a vacancy or impurity-vacancy point defect concentration of at least 1 ppm (paragraph 11). Chang et al. teaches synthetic type Ib diamond single crystals obtained from Element Six (paragraph 38). It is known in the art that type Ib diamonds contain nitrogen, but the nitrogen atoms are dispersed individually (isolated) rather than in clusters and are formed through HPHT or CVD processes. Chang et al. does not psecifya single growth sector. Barjon et al. teaches two CVD films grown, in identical conditions, one on a substrate face made up of a single <100> growth sector, and the other on a substrate face consisting of several sectors (page 689, paragraph 1). Barjon et al. teaches experiment demonstrates that, when using HPHT substrates, only faces consisting of a single <100> growth sector are suitable for homoepitaxial CVD diamond growth, if one wishes to avoid as much as possible the presence of dislocations during the growth (page 690, paragraph 3; Fig. 16). Barjon et al. teaches the need for careful substrate pre-treatment and selection (including choosing a single-sector face) to minimize defects in the growing films (abstract). It would have been obvious to one of ordinary skill in the art at the time of filing to use the CVD film grown on a substrate face made up of a single <100> growth sector for the diamond powder milling taught by Curmi et al. because it minimizes defects and dislocations. Curmi et al. in view of Barjon et al. do not teach wherein the particles in the powder have an average vacancy or impurity-vacancy point defect concentration, and a variation about the average vacancy or impurity-vacancy point defect concentration is no more than 40%, 30%, 20%, or 10%. Wrachtrup et al. teaches in quantum information processing the nitrogenvacancy (NV) color center in diamond has been demonstrated to be an efficient source for single photons1,2 and has been used to implement quantum key distribution in free space (page 3433, paragraph 1). Wrachtrup et al. teaches on average a 60-70 nm diameter crystal would be expected to have 0.15-0.2 NV centers which would give an estimated variance for data ranging from 0.15 to 0.2 that is no more than 40%, 30%, 20%, or 10% (page 3435, paragraph 5). It is clear that the NV centers taught by Chang et al. in view of Barjon et al. would necessarily give a variation about the average vacancy or impurity-vacancy point defect concentration is no more than 40%, 30%, 20%, or 10% (paragraph 36). Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to GUINEVER S GREGORIO whose telephone number is (571)270-5827. The examiner can normally be reached M-W 11 am - 9 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Coris Fung can be reached at 571-270-5713. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /GUINEVER S GREGORIO/Primary Examiner, Art Unit 1732 01/21/2025
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Prosecution Timeline

May 07, 2021
Application Filed
Jul 12, 2025
Final Rejection — §103
Sep 10, 2025
Examiner Interview Summary
Sep 10, 2025
Applicant Interview (Telephonic)
Jan 15, 2026
Request for Continued Examination
Jan 16, 2026
Response after Non-Final Action
Jan 21, 2026
Non-Final Rejection — §103 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
73%
Grant Probability
91%
With Interview (+18.5%)
3y 4m
Median Time to Grant
Moderate
PTA Risk
Based on 825 resolved cases by this examiner. Grant probability derived from career allow rate.

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