DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Response to Amendments
Amendments filed June 16, 2025 are acknowledged.
All rejections not explicitly maintained herein are withdrawn.
Election/Restrictions
4. In accordance with the MPEP 803.02, if upon examination of the elected species, no prior art is found that would anticipate or render obvious the instant invention based on the elected species, the search of the Markush-type claim will be extended (see MPEP 803.02). If prior art is then found that anticipates or renders obvious the non-elected species, the Markush-type claim will be rejected. It should be noted that the prior art search will not be extended unnecessarily to cover all non-elected species. Should Applicant overcome the rejection by amending the claim, the amended claim will be reexamined. Id. The prior art search will be extended to the extent necessary to determine patentability of the Markush-type claim. Id. In the event prior art is found during reexamination that renders obvious or anticipates the amended Markush-type claim, the claim will be rejected and the action made final. Id.
Status of Claims
5. Claims 1-3, 5-10, and 12-32 are pending in the instant application. Claims 3, 8, 12, 15-17, 21, 23-26, 28, and 30-32 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a non-elected invention and species. Therefore, claims 1-2, 5-7, 9-10, 13-14, 18-20, 22, 27, and 29 read on an elected invention and species and are therefore under consideration in the instant application.
Claim Objections
6. Claims 6, 19, 20, and 22 are objected to for depending on a rejected base claim.
Rejections - 35 USC § 102
7. In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status.
The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action:
A person shall be entitled to a patent unless –
(a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention.
8. Claims 1-2, 5, 7, 9, 14, 18, and 29 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by CAS Registry Number: RN 2397895-11-1. [Database Registry Chemical Abstracts Service, Columbus, Ohio, Accession No. RN 2397895-11-1, Entered STN: 01 Jan 2020].
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RN 2397895-11-1 anticipates the instant claims wherein Z is CH, Y1 is CR1, R1 is Rc, Rc is Br, Y2 is CR1, R1 is H, Y3 is CR1, R1 is H, X1 is NH, X2 is CH, R6 is H, LB is ethylene, a1 is 0, C is pyrrolidinyl.
Registry number 2397895-11-1 is available as prior art as of 01 Jan 2020, the date it was indexed into the CAplus database.
Regarding the compositions of claim 14, comprising the anticipatory compounds and an excipient, the Registry entry for Registry no. 2397895-11-1 discloses a mass solubility of 0.94 g/L, in unbuffered water at pH 10.96. This teaching of water anticipates the claimed composition, wherein the compounds are present with an excipient (i.e., water).
See MPEP 2128: ELECTRONIC PUBLICATIONS AS PRIOR ART Status as a "Printed Publication" An electronic publication, including an on-line database or Internet publication, is considered to be a “printed publication” within the meaning of 35 U.S.C. 102(a) and (b) provided the publication was accessible to persons concerned with the art to which the document relates. See In re Wyer, 655 F.2d 221, 227, 210 USPQ 790, 795 (CCPA 1981) Since this date represents the date that each compound entered the CAPlus database on STN, this represents the date that each compound was made accessible to the public.
The aforementioned compound anticipates the instantly claimed compounds: It is further noted that for the purposes of determining if a reference is a “printed publication” for the purposes of 102(b), MPEP 2128 states the following:
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where “prior art disclosures…on an on-line database are considered to be publicly available as of the date the item was publicly posted.” Since each of the database entries above lists the date that each compound was entered into the on-line database, the compounds were made publicly available as of that date in each citation, and the claims are anticipated.
9. Claims 1-2, 7, 9-10, 14, 27, and 29 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by CAS Registry Number: RN 1324084-62-9. [Database Registry Chemical Abstracts Service, Columbus, Ohio, Accession No. RN 1324084-62-9, Entered STN: 28 Aug 2011].
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RN 1324084-62-9 anticipates the instant claims wherein Z is CH, Y1 is CR1, R1 is H, Y2 is CR1, R1 is H, Y3 is CR1, R1 is H, X1 is NH, X2 is CH, R6 is H, LB is methylene, a1 is 0, C is thienyl.
Registry number 1324084-62-9 is available as prior art as of 28 Aug 2011, the date it was indexed into the CAplus database.
Regarding the compositions of claim 14, comprising the anticipatory compounds and an excipient, the Registry entry for Registry no. 1324084-62-9 discloses a mass solubility of 0.072 g/L, in unbuffered water at pH 7.04. This teaching of water anticipates the claimed composition, wherein the compounds are present with an excipient (i.e., water).
See MPEP 2128: ELECTRONIC PUBLICATIONS AS PRIOR ART Status as a "Printed Publication" An electronic publication, including an on-line database or Internet publication, is considered to be a “printed publication” within the meaning of 35 U.S.C. 102(a) and (b) provided the publication was accessible to persons concerned with the art to which the document relates. See In re Wyer, 655 F.2d 221, 227, 210 USPQ 790, 795 (CCPA 1981) Since this date represents the date that each compound entered the CAPlus database on STN, this represents the date that each compound was made accessible to the public.
The aforementioned compound anticipates the instantly claimed compounds: It is further noted that for the purposes of determining if a reference is a “printed publication” for the purposes of 102(b), MPEP 2128 states the following:
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where “prior art disclosures…on an on-line database are considered to be publicly available as of the date the item was publicly posted.” Since each of the database entries above lists the date that each compound was entered into the on-line database, the compounds were made publicly available as of that date in each citation, and the claims are anticipated.
Conclusion
10. Claim 13 is allowed.
11. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Samantha Shterengarts whose telephone number is (571)270-5316. The examiner can normally be reached on Monday thru Thursday 9-6pm.
If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Mr. Adam Milligan can be reached on 571-270-7674. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/SAMANTHA L SHTERENGARTS/Primary Examiner, Art Unit 1623