Prosecution Insights
Last updated: October 02, 2026
Application No. 17/399,207

MOLECULAR SENSOR BASED ON VIRTUAL BURIED NANOWIRE

Final Rejection §102§112§DP
Filed
Aug 11, 2021
Priority
Feb 28, 2012 — provisional 61/604,041 +3 more
Examiner
CHIN, CHRISTOPHER L
Art Unit
1677
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Ramot At Tel-aviv University Ltd.
OA Round
2 (Final)
81%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 81% — above average
81%
Career Allowance Rate
577 granted / 714 resolved
+20.8% vs TC avg
Strong +23% interview lift
Without
With
+22.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 8m
Avg Prosecution
24 currently pending
Career history
732
Total Applications
across all art units

Statute-Specific Performance

§101
3.4%
-36.6% vs TC avg
§103
27.4%
-12.6% vs TC avg
§102
17.6%
-22.4% vs TC avg
§112
36.9%
-3.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 714 resolved cases

Office Action

§102 §112 §DP
Notice of Pre-AIA or AIA Status The present application is being examined under the pre-AIA first to invent provisions. Claims 1-2, 4-9, and 18-27 are pending. Claims 3 and 10-17 are cancelled. Claim Interpretation 2. The following is a quotation of 35 U.S.C. 112(f): (f) Element in Claim for a Combination. – An element in a claim for a combination may be expressed as a means or step for performing a specified function without the recital of structure, material, or acts in support thereof, and such claim shall be construed to cover the corresponding structure, material, or acts described in the specification and equivalents thereof. The following is a quotation of pre-AIA 35 U.S.C. 112, sixth paragraph: An element in a claim for a combination may be expressed as a means or step for performing a specified function without the recital of structure, material, or acts in support thereof, and such claim shall be construed to cover the corresponding structure, material, or acts described in the specification and equivalents thereof. 3. The claims in this application are given their broadest reasonable interpretation using the plain meaning of the claim language in light of the specification as it would be understood by one of ordinary skill in the art. The broadest reasonable interpretation of a claim element (also commonly referred to as a claim limitation) is limited by the description in the specification when 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, is invoked. As explained in MPEP § 2181, subsection I, claim limitations that meet the following three-prong test will be interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph: (A) the claim limitation uses the term “means” or “step” or a term used as a substitute for “means” that is a generic placeholder (also called a nonce term or a non-structural term having no specific structural meaning) for performing the claimed function; (B) the term “means” or “step” or the generic placeholder is modified by functional language, typically, but not always linked by the transition word “for” (e.g., “means for”) or another linking word or phrase, such as “configured to” or “so that”; and (C) the term “means” or “step” or the generic placeholder is not modified by sufficient structure, material, or acts for performing the claimed function. Use of the word “means” (or “step”) in a claim with functional language creates a rebuttable presumption that the claim limitation is to be treated in accordance with 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph. The presumption that the claim limitation is interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, is rebutted when the claim limitation recites sufficient structure, material, or acts to entirely perform the recited function. Absence of the word “means” (or “step”) in a claim creates a rebuttable presumption that the claim limitation is not to be treated in accordance with 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph. The presumption that the claim limitation is not interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, is rebutted when the claim limitation recites function without reciting sufficient structure, material or acts to entirely perform the recited function. Claim limitations in this application that use the word “means” (or “step”) are being interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, except as otherwise indicated in an Office action. Conversely, claim limitations in this application that do not use the word “means” (or “step”) are not being interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, except as otherwise indicated in an Office action. 4. This application includes one or more claim limitations that do not use the word “means,” but are nonetheless being interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, because the claim limitation(s) uses a generic placeholder that is coupled with functional language without reciting sufficient structure to perform the recited function and the generic placeholder is not preceded by a structural modifier. Such claim limitation(s) is/are: a.) “circuitry that is configured to make one or more measurements of the conductivity of the conducting channel, and uses the measured conductivity to find an indication of the local concentration of the molecules near the position of the conducting channel” in claim 18. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. b.) “circuitry is configured to measure the conductivity of the conducting channel by one or more of measuring the current for a value of the voltage, measuring the voltage for a value of the current, and, for a value of one function of the current and the voltage, measuring a different function of the current and the voltage” in claim 19. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. c.) “circuitry is configured to measure a source to drain current at a source to drain voltage by measuring the source to drain current as a function of source to drain voltage for a plurality of values of the source to drain voltage, and uses the measured conductivity to calculate the local concentration of the adhering molecules by using the source to drain current as a function of the source to drain voltage to find a threshold voltage of the conducting channel, and using the threshold voltage to calculate the local concentration of the adhering molecules near the position of the conducting channel” in claim 20. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. d.) “circuitry is configured to control power supplies to successively apply different combinations of values of voltages to the left and right lateral gate electrodes and back gate electrode, changing one or more of a lateral position of the conducting channel in a left-right direction, a vertical position of the conducting channel in a direction perpendicular to the sensing surface, and a size and a shape of the conducting channel, and for each combination of values of gate voltages, measures the conductivity of the conducting channel, and uses the measured conductivities to find a concentration of the at least one type of molecules in the air sample” in claim 21. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. e.) “circuitry is configured to make the one or more measurements of conductivity of the conducting channel when the conducting channel is at a same lateral position in a left-right direction” in claim 22. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. f.) “circuitry is configured to control power supplies to successively apply different values of voltage to the lateral gate electrodes, changing one or more of a vertical position of the conducting channel in a direction perpendicular to the sensing surface, and a size and a shape of the conducting channel, and for each of the different values of gate voltages, measures the conductivity of the conducting channel, and uses the measured conductivities to find an indication of the concentration of the at least one type of molecules in the air sample” in claim 25. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. g.) “circuitry I configured to control power supplies to successively apply different values of voltage to the lateral gate electrodes, changing one or more of a size and a shape of the conducting channel, and for each of the different values of gate voltages, measures the conductivity of the conducting channel, and uses the measured conductivities to find an indication of the concentration of the at least one type of molecules in the air sample” in claim 26. The term “circuitry” is considered a generic placeholder and the instant specification does not discloses any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. Because this/these claim limitation(s) is/are being interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, it/they is/are being interpreted to cover the corresponding structure described in the specification as performing the claimed function, and equivalents thereof. If applicant does not intend to have this/these limitation(s) interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph, applicant may: (1) amend the claim limitation(s) to avoid it/them being interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph (e.g., by reciting sufficient structure to perform the claimed function); or (2) present a sufficient showing that the claim limitation(s) recite(s) sufficient structure to perform the claimed function so as to avoid it/them being interpreted under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph. Claim Rejections - 35 USC § 112 5. The 112(b) rejections of claims 5 and 22 in the office action dated 4/3/2026 are withdrawn in view of Applicant’s amendments. The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 18-23, 25, and 26 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 26 is vague because in lines 1-2 the phrase “the circuitry I configured to” is confusing. Claim limitations – a.) “circuitry that is configured to make one or more measurements of the conductivity of the conducting channel, and uses the measured conductivity to find an indication of the local concentration of the molecules near the position of the conducting channel” in claim 18. b.) “circuitry is configured to measure the conductivity of the conducting channel by one or more of measuring the current for a value of the voltage, measuring the voltage for a value of the current, and, for a value of one function of the current and the voltage, measuring a different function of the current and the voltage” in claim 19. c.) “circuitry is configured to measure a source to drain current at a source to drain voltage by measuring the source to drain current as a function of source to drain voltage for a plurality of values of the source to drain voltage, and uses the measured conductivity to calculate the local concentration of the adhering molecules by using the source to drain current as a function of the source to drain voltage to find a threshold voltage of the conducting channel, and using the threshold voltage to calculate the local concentration of the adhering molecules near the position of the conducting channel” in claim 20. d.) “circuitry is configured to control power supplies to successively apply different combinations of values of voltages to the left and right lateral gate electrodes and back gate electrode, changing one or more of a lateral position of the conducting channel in a left-right direction, a vertical position of the conducting channel in a direction perpendicular to the sensing surface, and a size and a shape of the conducting channel, and for each combination of values of gate voltages, measures the conductivity of the conducting channel, and uses the measured conductivities to find a concentration of the at least one type of molecules in the air sample” in claim 21. e.) “circuitry is configured to make the one or more measurements of conductivity of the conducting channel when the conducting channel is at a same lateral position in a left-right direction” in claim 22. f.) “circuitry is configured to control power supplies to successively apply different values of voltage to the lateral gate electrodes, changing one or more of a vertical position of the conducting channel in a direction perpendicular to the sensing surface, and a size and a shape of the conducting channel, and for each of the different values of gate voltages, measures the conductivity of the conducting channel, and uses the measured conductivities to find an indication of the concentration of the at least one type of molecules in the air sample” in claim 25. g.) “circuitry I configured to control power supplies to successively apply different values of voltage to the lateral gate electrodes, changing one or more of a size and a shape of the conducting channel, and for each of the different values of gate voltages, measures the conductivity of the conducting channel, and uses the measured conductivities to find an indication of the concentration of the at least one type of molecules in the air sample” in claim 26. invoke 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph. However, the written description fails to disclose the corresponding structure, material, or acts for performing the entire claimed function and to clearly link the structure, material, or acts to the function. The instant specification does not disclose any specific “circuitry” that is modified (i.e. “configured”) for carrying out the claimed function. Therefore, the claim is indefinite and is rejected under 35 U.S.C. 112(b) or pre-AIA 35 U.S.C. 112, second paragraph. Applicant may: (a) Amend the claim so that the claim limitation will no longer be interpreted as a limitation under 35 U.S.C. 112(f) or pre-AIA 35 U.S.C. 112, sixth paragraph; (b) Amend the written description of the specification such that it expressly recites what structure, material, or acts perform the entire claimed function, without introducing any new matter (35 U.S.C. 132(a)); or (c) Amend the written description of the specification such that it clearly links the structure, material, or acts disclosed therein to the function recited in the claim, without introducing any new matter (35 U.S.C. 132(a)). If applicant is of the opinion that the written description of the specification already implicitly or inherently discloses the corresponding structure, material, or acts and clearly links them to the function so that one of ordinary skill in the art would recognize what structure, material, or acts perform the claimed function, applicant should clarify the record by either: (a) Amending the written description of the specification such that it expressly recites the corresponding structure, material, or acts for performing the claimed function and clearly links or associates the structure, material, or acts to the claimed function, without introducing any new matter (35 U.S.C. 132(a)); or (b) Stating on the record what the corresponding structure, material, or acts, which are implicitly or inherently set forth in the written description of the specification, perform the claimed function. For more information, see 37 CFR 1.75(d) and MPEP §§ 608.01(o) and 2181. Claim Rejections - 35 USC § 102 9. The 102(b) rejection of claims 1-2 over Ahn et al (“Double-Gate Nanowire Field Effect Transistor for a Biosensor”, Nano Letters, 2010, 10, 2934-2938; herein referred to as Ahn) is withdrawn in view of Applicant’s amendments to claim 1. Double Patenting 10. The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13. The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer. 11. Claims 1, 4, 5, and 9 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-11 of U.S. Patent No. 10,054,562. Although the claims at issue are not identical, they are not patentably distinct from each other because patent ’562 claims a method that uses a system that anticipates the instant invention. Patent ‘562 claims: 1. A method of sensing molecules in a gas or liquid sample with a multi-gate field effect transistor having a conducting channel connecting a source region to a drain region, a position of the conducting channel in a lateral direction controllable by changing two lateral gate voltages, and the conductivity of the conducting channel affected by the molecules adhering to a sensing surface of the transistor at a position near the conducting channel, the method comprising: a) exposing the sensing surface to the gas or liquid sample; b) changing the position of the conducting channel in the lateral direction, and measuring a conductivity of the channel at a plurality of positions of the channel; and c) detecting the molecules by observing a change in conductivity of the conducting channel when it is in a position such that it passes close to one of the adhering molecules, or close to a fluctuation in a concentration of the adhering molecules on the sensing surface. 2. A method according to claim 1, wherein the multi-gate field effect transistor is a field effect transistor comprising a back gate electrode that affects one or both of an average distance and range of distance of the conducting channel from the sensing surface, the method also comprising adjusting a voltage of the back gate electrode to improve a sensitivity of the conductivity of the conducting channel to the adhering molecules. 3. A method according the claim 1, wherein changing the two lateral gate voltages affects a cross-sectional area of the conducting channel, a cross-sectional shape of the conducting channel, or both, at least partly independently of the position of the conducting channel in the lateral direction, as well as affecting the position of the conducting channel in the lateral direction. 4. A method according to claim 3, wherein changing a position of the conducting channel in the lateral direction comprises keeping the two lateral gate voltages at values such that the conducting channel has a width in the lateral direction no greater than 50% of a full range of the positions that the conducting channel can move to in the lateral direction. 5. A method according to claim 3, wherein changing a position of the conducting channel in the lateral direction comprises keeping the two lateral gate voltages at values such that the conducting channel has a width in the lateral direction no greater than 200 nanometers. 6. A method according to claim 1, wherein the sample comprises a gas sample. 7. A method according to claim 1, wherein the sample comprises a liquid sample, and exposing the sensing surface to the liquid sample comprises holding the liquid sample in a reservoir. 8. A method according to claim 1, wherein the field effect transistor has a first region extending from the source region to the drain region, and left and right lateral regions extending along the first region on either side, and the lateral gate electrodes create the conducting channel in the first region by producing an electric field in the left and right lateral regions. 9. A method according to claim 8, wherein the source region, drain region and first region are doped with dopants of a same sign, and the left and right lateral regions are doped with dopants of an opposite sign to the source region, drain region, and first region. 10. A method according to claim 9, wherein the concentration of dopants of the lateral regions extends into the first region, falling off gradually over a scale length greater than a width of the conducting channel. 11. A method according to claim 1, wherein exposing the sensing surface comprising exposing to a sample of air, and the gate voltages are such that a width of the conducting channel and a distance of the conducting channel from the sensing surface allow an equilibrium concentration of the adhering molecules to be determined when the concentration of the molecules in the air sample is only 100 parts per million. 12. Claims 1-9 and 18 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-11 and 17-18 of U.S. Patent No. 11,112,379. Although the claims at issue are not identical, they are not patentably distinct from each other because patent ‘379 claims a system and method of modifying a field effect transistor that anticipates the instant invention. Patent ‘379 claims: 1. A system for sensing at least one type of molecules in a gas or liquid sample, comprising: a) at least one multi-gate field effect transistor, comprising: 1) a piece of semiconductor with a first region extending between a source region and a drain region, and left and right lateral regions extending along the first region on different sides; 2) left and right lateral gate electrodes that respectively produce an electric field in the left and right lateral regions, creating a conducting channel in the first region when appropriate voltages are applied to them, a position of the conducting channel depending on the applied voltages; 3) a sensing surface adjacent to the first region, that molecules of the at least one type adhere to when the sensing surface is exposed to the molecules, the conductivity of the conducting channel being measurably affected by a local concentration of the adhering molecules near the position of the conducting channel; and b) a controller that controls power supplies to successively apply different voltages to the lateral gate electrodes of the transistor, moving the conducting channel to a plurality of different positions in a lateral direction, and at each position uses a circuit to measure the conductivity of the conducting channel by measuring a source to drain current at a source to drain voltage, and uses the measured conductivity to calculate a local concentration of the adhering molecules at that position. 2. A system according to claim 1, wherein the sensing surface is coated with a ligand that binds specifically to the molecules that are being sensed. 3. A system according to claim 1, wherein the source region and drain region are doped with dopants of a same sign, and the left and right lateral regions are doped with dopants of an opposite sign to the source and drain regions. 4. A system according to claim 3, wherein the first region is doped with a dopant of the same sign as the source and drain regions. 5. A system according to claim 4, wherein the concentration of dopants of the lateral regions extends into the first region, falling off gradually over a scale length greater than the width of the conducting channel. 6. A product manufactured by a process comprising: a) providing the system of claim 4; and b) heat treating the field effect transistor under conditions such that some of the dopants from the left and right lateral regions diffuse into the first region, reducing an effective width of the first region by at least 30% at its narrowest point, but not reducing the effective width to zero at any point. 7. A system according to claim 1, wherein the first region is narrower than 1 micrometer between the left and right lateral regions. 8. A system according to claim 1, wherein the field effect transistor also comprises a back gate electrode, located in a direction away from the sensing surface and separated from the first region at least by an insulator layer. 9. A system according to claim 1, which, for at least one choice of gate electrode voltages, would have a width of the conducting channel and a distance of the conducting channel from the sensing surface such that an equilibrium concentration of the adhering molecules could be determined when a concentration of the molecules in air that the sensing surface is exposed to is only 100 parts per million. 10. A system according to claim 1, wherein the at least one field effect transistor comprises a plurality of field effect transistors, with their sensing surfaces chemically modified in substantially a same way for binding to molecules in a gas or liquid sample, and the controller controls power supplies to change the lateral gate voltages to change the position of the conductive channel in a lateral direction in each transistor, and uses a circuit to measure the conductivity of the conductive channel at a plurality of different positions in each transistor, after exposing the sensing surfaces of the transistors to the sample, and calculates a greatest concentration of said molecules adhering near any of the positions, for each transistor, from the measured conductivities, and calculates an average over the transistors of the greatest concentrations of the adhering molecules. 11. A system according to claim 1 for use as an electronic nose for sensing a plurality of different types of molecules, wherein the at least one field effect transistor comprises a plurality of field effect transistors with sensing surfaces having different chemical properties, causing them to have different relative tendencies for the different molecules to adhere to them, and the controller controls power supplies to change lateral gate voltages to change the position of the conducting channel in a lateral direction, and calculates a concentration of any adhering molecules near each of the positions of the conducting channels after the sensing surfaces are exposed to a gas or liquid sample, from the conductivity measured at each of the positions, for each transistor, and finds the type of molecules present in the sample by comparing a pattern of the concentrations of molecules adhering to each field effect transistor, to an expected pattern of concentrations of adhering molecules for each of the types of molecules. 17. A system according to claim 1, wherein the controller measures the source to drain current at a source to drain voltage by one or more of keeping the voltage at a constant value at the different positions and measuring changes in the current, keeping the current at a constant value at the different positions and measuring changes in the voltage, and keeping a function of the current and the voltage at a constant value at the different positions and measuring changes in a different function of the current and the voltage. 18. A method of modifying a multi-gate field effect transistor usable for sensing at least one type of molecules in a gas or liquid sample and comprising: a) a piece of semiconductor with a first region extending between a source region and a drain region, and left and right lateral regions extending along the first region on different sides, the source region and drain region doped with dopants of a same sign, the left and right lateral regions doped with dopants of an opposite sign to the source and drain regions, and the first region doped with a dopant of the same sign as the source and drain regions; b) left and right lateral gate electrodes that respectively produce an electric field in the left and right lateral regions, creating a conducting channel in the first region when appropriate voltages are applied to them, a position of the conducting channel depending on the applied voltages; and c) a sensing surface adjacent to the first region, that molecules of the at least one type adhere to when the sensing surface is exposed to the molecules, the conductivity of the conducting channel being measurably affected by a local concentration of the adhering molecules near the position of the conducting channel; the method comprising heat treating the transistor under conditions such that some of the dopants from the left and right lateral regions diffuse into the first region, reducing an effective width of the first region by at least 30% at its narrowest point, but not reducing the effective width to zero at any point. Response to Arguments Applicant's arguments filed 7/3/26 have been fully considered but they are not persuasive. In response to the nonstatutory double patenting rejections over US Patents 10,054,562 and 11,112,379 Applicants argue that Examiner has not made a prima facie case of double patenting because he has not mapped from the claims of the conflicting claims to the instant claims. Applicant’s arguments have been considered but are not convincing because its readily apparent upon reading of the conflicting claims that components of the instant system are in the claims of the conflicting patents. For example, claims 1, 8, and 9 recite a system being used in a method that anticipates the system of instant claim 1 and claims 1 and 3 of patent ‘379 anticipate the system of instant claim 1. Allowable Subject Matter 15. Claims 1, 2, 4-9 and 18-27 are free of the prior art of record because the closest prior art being Ahn et al does not teach a system with the additional limitations recited in the aforementioned claims. Claims 24 and 25 objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. 17. Any inquiry concerning this communication or earlier communications from the examiner should be directed to CHRISTOPHER L CHIN whose telephone number is (571)272-0815. The examiner can normally be reached Monday - Friday, 10:00am - 6:30pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Bao-Thuy Nguyen can be reached at 571-272-0824. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /CHRISTOPHER L CHIN/Primary Examiner, Art Unit 1677 9/12/26
Read full office action

Prosecution Timeline

Aug 11, 2021
Application Filed
Jan 05, 2022
Response after Non-Final Action
Apr 03, 2026
Non-Final Rejection mailed — §102, §112, §DP
Jul 03, 2026
Response Filed
Sep 16, 2026
Final Rejection mailed — §102, §112, §DP (current)

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PROCESS OF DIRECTLY DETECTING AND IDENTIFYING A MICROORGANISM IN A BIOLOGICAL SAMPLE DILUTED IN AN ENRICHMENT BROTH
5y 7m to grant Granted Aug 04, 2026
Patent 12699086
MODIFIED ELISA WITH HEMOGLOBIN CORRECTION APPARATUS AND METHODS THEREOF
3y 3m to grant Granted Aug 04, 2026
Patent 12693221
AUTOMATED IMMUNOANALYZER SYSTEM FOR PERFORMING DIAGNOSTIC ASSAYS FOR AUTOIMMUNE AND INFECTIOUS DISEASES
6y 0m to grant Granted Jul 28, 2026
Patent 12693291
METHODS AND DEVICES FOR USING MUCOLYTIC AGENTS INCLUDING N-ACETYL CYSTEINE (NAC)
5y 3m to grant Granted Jul 28, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
81%
Grant Probability
99%
With Interview (+22.7%)
3y 8m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 714 resolved cases by this examiner. Grant probability derived from career allowance rate.

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