Prosecution Insights
Last updated: April 19, 2026
Application No. 17/495,593

METHOD AND SYSTEM FOR THERMAL STIMULATION OF TARGETED NEURAL CIRCUITS FOR NEURODEGENERATIVE DISORDERS

Final Rejection §101§112§DP
Filed
Oct 06, 2021
Examiner
LANNU, JOSHUA DARYL DEANON
Art Unit
3791
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Kambix Innovations LLC
OA Round
2 (Final)
82%
Grant Probability
Favorable
3-4
OA Rounds
2y 11m
To Grant
99%
With Interview

Examiner Intelligence

Grants 82% — above average
82%
Career Allow Rate
761 granted / 924 resolved
+12.4% vs TC avg
Strong +24% interview lift
Without
With
+23.9%
Interview Lift
resolved cases with interview
Typical timeline
2y 11m
Avg Prosecution
45 currently pending
Career history
969
Total Applications
across all art units

Statute-Specific Performance

§101
9.8%
-30.2% vs TC avg
§103
28.1%
-11.9% vs TC avg
§102
22.5%
-17.5% vs TC avg
§112
32.3%
-7.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 924 resolved cases

Office Action

§101 §112 §DP
DETAILED ACTION This action is a response to the filing on 7/9/2025. Examiner acknowledges the cancellation of claims 1-20 and the addition of new claims 21-39. Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Arguments Applicant's arguments filed 7/9/2025 have been fully considered but they are not persuasive. Applicant’s amendments have overcome the previous rejections but have introduced new rejections, which are discussed below. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 36-39 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claims 36-38 are unclear. The claims appear to further limit the intended use of claim 34, which make it appear to be combining method steps with a system claim. This makes it unclear as to where infringement can occur (MPEP 2173.05(p)(II)). Claim 39 recites the limitation "the presynaptic cradle" in line 25. There is insufficient antecedent basis for this limitation in the claim. The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claim 27 is rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Claim 27 is dependent on a claim that has been cancelled. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. For the purposes of compact prosecution, Examiner is interpreting claim 27 to be dependent on claim 21. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Section 33(a) of the America Invents Act reads as follows: Notwithstanding any other provision of law, no patent may issue on a claim directed to or encompassing a human organism. Claims 36-38 are rejected under 35 U.S.C. 101 and section 33(a) of the America Invents Act as being directed to or encompassing a human organism. See also Animals - Patentability, 1077 Off. Gaz. Pat. Office 24 (April 21, 1987) (indicating that human organisms are excluded from the scope of patentable subject matter under 35 U.S.C. 101). Claim 36 recites “the magnetic field is applied to the brain” in lines 1-2. Claim 37 recites “nanoparticles are delivered into brain capillaries” in lines 1-2. Claim 38 recites “nano-transducers are delivered into brain capillaries” in lines 2-3. These are positive recitations to a human organism. Amending the claim in a manner that uses “configured to” or “adapted to” language would resolve the issue. Double Patenting A rejection based on double patenting of the “same invention” type finds its support in the language of 35 U.S.C. 101 which states that “whoever invents or discovers any new and useful process... may obtain a patent therefor...” (Emphasis added). Thus, the term “same invention,” in this context, means an invention drawn to identical subject matter. See Miller v. Eagle Mfg. Co., 151 U.S. 186 (1894); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Ockert, 245 F.2d 467, 114 USPQ 330 (CCPA 1957). A statutory type (35 U.S.C. 101) double patenting rejection can be overcome by canceling or amending the claims that are directed to the same invention so they are no longer coextensive in scope. The filing of a terminal disclaimer cannot overcome a double patenting rejection based upon 35 U.S.C. 101. Claim 22 is/are rejected under 35 U.S.C. 101 as claiming the same invention as that of claim 22 of prior U.S. Patent No. 11,147,982. This is a statutory double patenting rejection. The limitations of claim 21 and claim 22 claim the same method steps disclosed in claim 1 of US 11,147,982. The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13. The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer. Claims 21 and 23-33 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-13 of U.S. Patent No. 11,147,982. Although the claims at issue are not identical, they are not patentably distinct from each other because claims 1-13 of U.S. Patent No. 11,147,982 disclose species claims that anticipate the current genus claims. All limitations of claim 21 are present in claim 1 of US 11,147,982. The only difference is that claim 1 of US 11,147,982 recites the presence of additional elements that make it a species of the present genus claim. The limitations of claim 23 are disclosed by claim 2 of US 11,147,982. The limitations of claim 24 are disclosed by claim 5 of US 11,147,982. The limitations of claim 25 are disclosed by claims 3 and 4 of US 11,147,982. The limitations of claim 26 are disclosed by claim 6 of US 11,147,982. The limitations of claim 27 are disclosed by claim 7 of US 11,147,982. The limitations of claim 28 are disclosed by claim 8 of US 11,147,982. The limitations of claim 29 are disclosed by claim 9 of US 11,147,982. The limitations of claim 30 are disclosed by claim 10 of US 11,147,982. The limitations of claim 31 are disclosed by claim 11 of US 11,147,982. The limitations of claim 32 are disclosed by claim 12 of US 11,147,982. The limitations of claim 33 are disclosed by claim 13 of US 11,147,982. Allowable Subject Matter Claims 34 and 35 are allowed. Claims 21-33 and 36-39 would be allowable if rewritten to overcome the double patenting rejections, 101 rejections, or the rejection(s) under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), 2nd paragraph, set forth in this Office action. The following is a statement of reasons for the indication of allowable subject matter: In regards to claim 21 and 34, the closest prior art found does not teach or suggest a method or device that implements a method, as claimed by Applicant, where the method determines characteristics that diminish adverse impacts of magnetothermal stimulation treatment and uses the characteristics in a treatment of a neurodegenerative disorder that thermally stimulates neural circuits with remotely controlled nano-transducers where the characteristics are indicative of the physical attributes comprises at least one of blood flow dynamics and heat transfer across at least one area of the brain, and regulated neural signaling. Claims 22-33 and 36-38 are dependent on allowable matter from claim 21 or 34 and would be allowable once the double patenting, 101, and/or 112 rejections are overcome. Claim 35 is dependent on allowed matter from claim 34 and are allowed. In regards to claim 39, the prior art of record does not teach or suggest a device, as claimed by Applicant, where the device has a processor that implements a method stored in a memory where the method determines characteristics that diminish adverse impacts of magnetothermal stimulation treatment and uses the characteristics in a treatment of a neurodegenerative disorder that thermally stimulates neural circuits with remotely controlled nano-transducers where the characteristics include data indicative of a prediction of a sodium/calcium exchanger behavior as an additional source of calcium at the presynaptic cradle as a function of an induced temperature included in a temperature profile. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JOSHUA DARYL DEANON LANNU whose telephone number is (571)270-1986. The examiner can normally be reached Monday-Thursday 8 AM - 5 PM, Friday 8 AM -12 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Charles Marmor can be reached at (571) 272-4730. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JOSHUA DARYL D LANNU/Examiner, Art Unit 3791 /CARRIE R DORNA/Primary Examiner, Art Unit 3791
Read full office action

Prosecution Timeline

Oct 06, 2021
Application Filed
Jan 10, 2025
Non-Final Rejection — §101, §112, §DP
Apr 15, 2025
Response Filed
Apr 15, 2025
Response after Non-Final Action
Jun 28, 2025
Response Filed
Jun 28, 2025
Response after Non-Final Action
Jul 09, 2025
Response Filed
Oct 17, 2025
Final Rejection — §101, §112, §DP (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
82%
Grant Probability
99%
With Interview (+23.9%)
2y 11m
Median Time to Grant
Moderate
PTA Risk
Based on 924 resolved cases by this examiner. Grant probability derived from career allow rate.

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