Last updated: August 16, 2026

Application No. 17/550,051

Use of FOXP3 Enhancers to Modulate Regulatory T Cells

Final Rejection

Filed

Dec 14, 2021

Examiner

WILSON, MICHAEL C

Art Unit

1638

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

St. Jude Children's Research Hospital Inc.

OA Round

4 (Final)

This examiner grants 41% of cases after interview

— +17.5% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 934 resolved cases, 2023–2026

Examiner Intelligence

WILSON, MICHAEL C View full profile →

Grants 41% of resolved cases

Career Allowance Rate

387 granted / 934 resolved

-18.6% vs TC avg

Strong +18% interview lift

Without

With

+17.5%

Interview Lift

resolved cases with interview

Typical timeline

3y 8m

Avg Prosecution

60 currently pending

Career history

1005

Total Applications

across all art units

Statute-Specific Performance

§101

4.4%

-35.6% vs TC avg

§103

29.5%

-10.5% vs TC avg

§102

15.9%

-24.1% vs TC avg

§112

39.3%

-0.7% vs TC avg

Black line = Tech Center average estimate • Based on career data from 934 resolved cases

Prosecution Timeline

Show 2 earlier events

Jan 09, 2025

Response Filed

Apr 10, 2025

Final Rejection mailed

Jul 10, 2025

Response after Non-Final Action

Sep 02, 2025

Request for Continued Examination

Sep 06, 2025

Response after Non-Final Action

Sep 16, 2025

Non-Final Rejection mailed

Dec 05, 2025

Response Filed

Feb 26, 2026

Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

18/316,461

Patent 12677813

NON-HUMAN ANIMALS HAVING A HUMANIZED PROGRAMMED CELL DEATH 1 GENE

3y 2m to grant Granted Jul 14, 2026

17/720,369

Patent 12674177

AAV VECTORS FOR VASCULAR GENE THERAPY IN CORONARY HEART DISEASE AND PERIPHERAL ISCHEMIA

4y 2m to grant Granted Jul 07, 2026

17/081,470

Patent 12582105

GENETICALLY MODIFIED T CELL RECEPTOR MICE

5y 4m to grant Granted Mar 24, 2026

18/511,290

Patent 12577588

AAV CAPSIDS WITH INCREASED TROPISM TO BRAIN TISSUE

2y 4m to grant Granted Mar 17, 2026

15/734,535

Patent 12568940

TRANSGENIC CHICKEN HAVING AN ENDOGENOUS IMMUNOGLOBULIN HEAVY CHAIN GENE IN WHICH THE IGY CH1 CODING SEQUENCE IS FUNCTIONALLY DELETED

5y 3m to grant Granted Mar 10, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

5-6

Expected OA Rounds

41%

Grant Probability

59%

With Interview (+17.5%)

3y 8m (~0m remaining)

Median Time to Grant

High

PTA Risk

Based on 934 resolved cases by this examiner. Grant probability derived from career allowance rate.