Last updated: April 19, 2026

Application No. 17/550,051

Use of FOXP3 Enhancers to Modulate Regulatory T Cells

Final Rejection

Filed

Dec 14, 2021

Examiner

WILSON, MICHAEL C

Art Unit

1638

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

St. Jude Children's Research Hospital

OA Round

4 (Final)

This examiner grants 42% of cases after interview

— +17.7% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 921 resolved cases, 2023–2026

Examiner Intelligence

WILSON, MICHAEL C View full profile →

Grants 42% of resolved cases

Career Allow Rate

384 granted / 921 resolved

-18.3% vs TC avg

Strong +18% interview lift

Without

With

+17.7%

Interview Lift

resolved cases with interview

Typical timeline

3y 9m

Avg Prosecution

76 currently pending

Career history

997

Total Applications

across all art units

Statute-Specific Performance

§101

5.1%

-34.9% vs TC avg

§103

25.3%

-14.7% vs TC avg

§102

20.7%

-19.3% vs TC avg

§112

36.5%

-3.5% vs TC avg

Black line = Tech Center average estimate • Based on career data from 921 resolved cases

Prosecution Timeline

Dec 14, 2021

Application Filed

Oct 18, 2024

Non-Final Rejection

Jan 09, 2025

Response Filed

Apr 05, 2025

Final Rejection

Jul 10, 2025

Response after Non-Final Action

Sep 02, 2025

Request for Continued Examination

Sep 06, 2025

Response after Non-Final Action

Sep 12, 2025

Non-Final Rejection

Dec 05, 2025

Response Filed

Feb 24, 2026

Final Rejection (current)

Precedent Cases

Applications granted by this same examiner with similar technology

17/081,470

Patent 12582105

GENETICALLY MODIFIED T CELL RECEPTOR MICE

2y 5m to grant Granted Mar 24, 2026

18/511,290

Patent 12577588

AAV CAPSIDS WITH INCREASED TROPISM TO BRAIN TISSUE

2y 5m to grant Granted Mar 17, 2026

15/734,535

Patent 12568940

TRANSGENIC CHICKEN HAVING AN ENDOGENOUS IMMUNOGLOBULIN HEAVY CHAIN GENE IN WHICH THE IGY CH1 CODING SEQUENCE IS FUNCTIONALLY DELETED

2y 5m to grant Granted Mar 10, 2026

16/078,680

Patent 12570981

COMPOSITIONS AND METHODS FOR REGULATING MYELINATION

2y 5m to grant Granted Mar 10, 2026

17/642,406

Patent 12565638

METHOD OF DIFFERENTIATING PLURIPOTENT OR EPIBLAST CELLS INTO IMMATURE OOCYTES

2y 5m to grant Granted Mar 03, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.

Prosecution Projections

5-6

Expected OA Rounds

42%

Grant Probability

59%

With Interview (+17.7%)

3y 9m

Median Time to Grant

High

PTA Risk

Based on 921 resolved cases by this examiner. Grant probability derived from career allow rate.