Prosecution Insights
Last updated: July 05, 2026
Application No. 17/550,286

ALKYLPYRIDINIUM COUMARIN DYES AND USES IN SEQUENCING APPLICATIONS

Non-Final OA §112
Filed
Dec 14, 2021
Priority
Dec 17, 2020 — provisional 63/127,044
Examiner
COLEMAN, BRENDA LIBBY
Art Unit
1624
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Illumina Cambridge Limited
OA Round
2 (Non-Final)
75%
Grant Probability
Favorable
2-3
OA Rounds
0m
Est. Remaining
90%
With Interview

Examiner Intelligence

Grants 75% — above average
75%
Career Allowance Rate
1215 granted / 1627 resolved
+14.7% vs TC avg
Strong +16% interview lift
Without
With
+15.6%
Interview Lift
resolved cases with interview
Typical timeline
2y 5m
Avg Prosecution
46 currently pending
Career history
1663
Total Applications
across all art units

Statute-Specific Performance

§101
2.7%
-37.3% vs TC avg
§103
9.8%
-30.2% vs TC avg
§102
12.5%
-27.5% vs TC avg
§112
49.7%
+9.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1627 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claims 1, 2, 4, 7, 9, 10, 12, 13, 15, 18, 19, 21-24, 26, 28-30, 32-34 and 37-52 are pending in the application. This action is in response to applicants' amendment dated March 17, 2026. Claims 1 and 1, 7 and 30 have been amended and claim 5 has been canceled. Response to Amendment Applicant's arguments filed March 17, 2026 have been fully considered with the following effect: With regards to the 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph rejections, labeled paragraph 3a), b), c) and d) of the last office action, the applicant’s amendments and remarks have been fully considered but they are not persuasive. a-d) The applicants’ stated that definiteness of a claim language must be analyzed, not in a vacuum, but in light of: (A) The content of the particular application disclosure; (B) The teachings of the prior art; and (C) The claim interpretation that would be given by one possessing the ordinary skill in the pertinent art at the time the invention was made. The applicants point to paragraph [0097] of the Patent Application Publication 2022/0195196 which states that "[a]s understood by one of ordinary skill in the art, a compound described herein may exist in ionized form, e.g., -CO2, -SO₃ or -O-SO₃⁻. If a compound contains a positively or negatively charged substituent group, for example, SO₃, it may also contain a negatively or positively charged counterion such that the compound as a whole is neutral. In other aspects, the compound may exist in a salt form, where the counterion is provided by a conjugate acid or base.” However, the applicants are claiming compound of Formula (I), a salt or a mesomeric form. A compound is neutral, a salt would contain a counterion and the mesomeric effect is the polarity that develops in a compound as a result of interaction between two bonds or a bond a lone pair of electrons. If the only charged atom is the nitrogen of the R1 variable the result is a cation not a compound. For example, a sodium ion is the positive cation where the sodium atom loses one electron and the neutral compound sodium chloride is electrically neutral. Claims 1, 2, 4, 7, 9, 10, 12, 13, 15, 18, 19, 21-24, 26 and 28 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which applicant regards as the invention, for reasons of record and stated above. The applicant's amendments and arguments are sufficient to overcome the 35 U.S.C. 102(a)(1), anticipation rejection, labeled paragraphs 4) through 15) in the last office action, which are hereby withdrawn. The applicant's amendments and arguments are sufficient to overcome the nonstatutory double patenting rejection, labeled paragraphs 16) and 17) in the last office action, which are hereby withdrawn. This application contains claims 29, 30, 32-34 and 37-52 are drawn to an invention nonelected without traverse in the reply filed on October 7, 2025. A complete reply to the final rejection must include cancellation of nonelected claims or other appropriate action (37 CFR 1.144) See MPEP § 821.01. Conclusion THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to BRENDA L COLEMAN whose telephone number is (571)272-0665. The examiner can normally be reached Mon-Fri 10-6 (flex). Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey H. Murray can be reached at 571-272-9023. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRENDA L COLEMAN/Primary Examiner, Art Unit 1624
Read full office action

Prosecution Timeline

Dec 14, 2021
Application Filed
Dec 31, 2025
Non-Final Rejection mailed — §112
Mar 17, 2026
Response Filed
Apr 13, 2026
Final Rejection mailed — §112
Jun 11, 2026
Response after Non-Final Action

Precedent Cases

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COMPOSITIONS CONTAINING NICOTINAMIDE AND VITAMIN B6 AND METHODS OF USING SUCH COMPOSITIONS FOR PROMOTING MUSCLE GROWTH
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Patent 12648986
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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
75%
Grant Probability
90%
With Interview (+15.6%)
2y 5m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1627 resolved cases by this examiner. Grant probability derived from career allowance rate.

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