Prosecution Insights
Last updated: July 17, 2026
Application No. 17/598,545

SYSTEMS AND METHODS FOR BISTABLE OLIGOMERIC MACHINES

Final Rejection §112
Filed
Sep 27, 2021
Priority
Mar 27, 2019 — provisional 62/824,610 +1 more
Examiner
JARRELL, NOBLE E
Art Unit
1699
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Molecular Machines Corporation Ltd.
OA Round
2 (Final)
81%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
90%
With Interview

Examiner Intelligence

Grants 81% — above average
81%
Career Allowance Rate
837 granted / 1032 resolved
+21.1% vs TC avg
Moderate +9% lift
Without
With
+9.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 11m
Avg Prosecution
67 currently pending
Career history
1087
Total Applications
across all art units

Statute-Specific Performance

§101
1.2%
-38.8% vs TC avg
§103
21.7%
-18.3% vs TC avg
§102
18.8%
-21.2% vs TC avg
§112
33.4%
-6.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1032 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Amendment The amendment filed 2026 February 4 is acknowledged. The rejections under 35 U.S.C. 112 and 102 are overcome for the following reasons: Berndt (cited in previous action) does not describe an acrylamide, acrylic acid, methacrylamide, or a methacrylate unit; Liles and Wang do not describe either of these units either; lastly, the new method of connection is enabled in claim 1. Claims 34-49 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to nonelected inventions, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on 2025 April 10. Information Disclosure Statement The information disclosure statement (IDS) submitted on 2025 April 10 was submitted in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statement is being considered by the examiner. Claim Rejections - 35 USC § 112 Claims 10-12, 19-20, and 25-33 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claims 10-12, 19-20, 25, and 33 lack antecedent basis to parent claims 1 and 26 respectively. In amended claim 1 the repeating units of an oligomer are limited to acrylamide, acrylic acid, methacrylamide, and methacrylate. Claim 26 does not recite the metes and bounds of a oligomeric module. In the dependent claims poly(N-isopropylacrylamide) is recited. Hence the poly(N-isopropylacrylamide) in claim 33 lacks antecedent basis. The metes and bounds of each oligomer module are not recited in the specified claims. Additionally, can the oligomeric modules be the same, or are they required to be different? How are the two oligomeric modules joined together? The claims only specify at a bend or hinge location but now how they are connected. Conclusion Claims 1-9, 13-18, and 21-24 are allowed. Claims 10-12, 19-20, and 25-33 are not allowable. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. The following is a statement of reasons for the indication of allowable subject matter: BERNDT (Langmuir, 2006, 22, 459-468) describes the properties of a poly-N-isopropylacrylamide-poly-N-isopropylmethacylamide core shell microgel changes when the lower critical solution temperature (referred to as LCST) is varied (abstract; page 459, second column, paragraph 2; page 462, second column, fourth paragraph to page 468, second column, first paragraph). Through the use of small-angle neutron scattering, the structure of the poly-N-isopropylacrylamide-poly-N-isopropylmethacylamide core shell microgel was analyzed. As an example, figure 4 shows the SANS scattering data at high temperatures (page 463; page 463, second column, paragraph 3 to page 464, first compound, paragraph 2). In this reference the stimulus is temperature change. This reference does not anticipate or render obvious a system of claim 1 because poly-N-isopropylacrylamide-poly-N-isopropylmethacylamide is not permitted due to the new claim amendments with respect to the recited repeating units of an oligomeric module. Any inquiry concerning this communication or earlier communications from the examiner should be directed to NOBLE E JARRELL whose telephone number is (571)272-9077. The examiner can normally be reached 9:00 AM to 5:00 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Fereydoun Sajjadi can be reached at 571-272-3311. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /NOBLE E JARRELL/Primary Examiner, Art Unit 1699
Read full office action

Prosecution Timeline

Sep 27, 2021
Application Filed
Sep 27, 2021
Response after Non-Final Action
Aug 07, 2025
Non-Final Rejection mailed — §112
Feb 04, 2026
Response Filed
May 20, 2026
Final Rejection mailed — §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
81%
Grant Probability
90%
With Interview (+9.3%)
2y 11m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1032 resolved cases by this examiner. Grant probability derived from career allowance rate.

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