Prosecution Insights
Last updated: August 18, 2026
Application No. 17/606,720

CF3-, OCF3-, SCF3-, and SF5-Containing Antibacterial Agents

Final Rejection §112
Filed
Oct 26, 2021
Priority
Apr 26, 2019 — provisional 62/838,961 +1 more
Examiner
KUCKLA, ANNA GRACE
Art Unit
1626
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Purdue Research Foundation
OA Round
4 (Final)
52%
Grant Probability
Moderate
5-6
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 52% of resolved cases
52%
Career Allowance Rate
22 granted / 42 resolved
-7.6% vs TC avg
Strong +55% interview lift
Without
With
+55.0%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
54 currently pending
Career history
86
Total Applications
across all art units

Statute-Specific Performance

§101
2.1%
-37.9% vs TC avg
§103
32.4%
-7.6% vs TC avg
§102
23.9%
-16.1% vs TC avg
§112
23.6%
-16.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 42 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Status of Claims Claims 1-2, 10, 14-15, 23-25, 27 and 34-38 are pending in the instant application. Claims 1, 14, 23 and 25 are amended, claims 3-9, 11-13, 16-22, 26 and 28-33 are cancelled and claim 38 is added via the amendment filed April 16th, 2026. Withdrawn Rejections Applicant’s arguments and amendments, filed April 16th, 2026, with respect to the 35 U.S.C. 102 rejection of claims 1-2 and 37 have been fully considered and are persuasive. The 35 U.S.C. 102 rejection of claims 1-2 and 37 has been withdrawn. Applicant has overcome this rejection by amending claim 1 to recite that R2 can only be a linear or branched alkyl and not a cycloalkyl. Response to Remarks Applicant’s arguments are moot as Applicant’s amendments have overcome the rejection presented in the previous Office action. However, Applicant’s amendments have necessitated a new grounds rejection. Restriction/Election The instant claims are being examined according to MPEP 803.02 where the search and examination has been extended to include the entire scope of claims 1-2, 14 and 37-38. Subject matter outside the scope of the elected species and expanded search and examination is withdrawn. As not all of the claims drawn to the elected species are allowable, the restriction requirement is maintained. As such, claims 10, 15, 23-25, 27 and 34-36 are withdrawn from consideration. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claim 38 is rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Applicant’s amendment has necessitated this rejection. Claim 38 recites that R2 can be a cyclopentyl. However, claim 1, the claim from which claim 38 depends only allows for R2 to be a linear or branched alkyl. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Closest Prior Art The closest prior art in terms of structural similarity to the instantly claimed compounds is Sintim et al (WO 2019/199496 A1). Sintim teaches the following compound (compound HSGN-133): PNG media_image1.png 188 504 media_image1.png Greyscale . However, the prior art compound has SO2CF3, where the prior art compound requires -SCF3 or -SF5. Further, the genus formula of the prior art does not allow for the necessary changes to be made to arrive at the instantly claimed compounds or provide motivation to make said changes. As such, the compounds are novel and nonobvious. Conclusion Claims 1-2, 14 and 37 are allowed. Claim 38 is rejected. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Anna Grace Kuckla whose telephone number is (703)756-5610. The examiner can normally be reached Monday-Friday 7:30-5. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Clinton A Brooks can be reached at (571)270-7682. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /A.G.K./Examiner, Art Unit 1626 /FEREYDOUN G SAJJADI/Supervisory Patent Examiner, Art Unit 1699
Read full office action

Prosecution Timeline

Show 2 earlier events
Feb 24, 2025
Response Filed
Apr 17, 2025
Final Rejection mailed — §112
Aug 18, 2025
Response after Non-Final Action
Sep 16, 2025
Request for Continued Examination
Oct 02, 2025
Response after Non-Final Action
Oct 17, 2025
Non-Final Rejection mailed — §112
Apr 16, 2026
Response Filed
Jun 26, 2026
Final Rejection mailed — §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
52%
Grant Probability
99%
With Interview (+55.0%)
3y 4m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 42 resolved cases by this examiner. Grant probability derived from career allowance rate.

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