Prosecution Insights
Last updated: October 25, 2026
Application No. 17/607,815

KCNT1 INHIBITORS AND METHODS OF USE

Final Rejection §102
Filed
Oct 29, 2021
Priority
May 03, 2019 — provisional 62/842,855 +4 more
Examiner
HUTTER, GILLIAN A
Art Unit
1625
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Praxis Precision Medicines Inc.
OA Round
6 (Final)
54%
Grant Probability
Moderate
7-8
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 54% of resolved cases
54%
Career Allowance Rate
67 granted / 123 resolved
-5.5% vs TC avg
Strong +46% interview lift
Without
With
+46.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 11m
Avg Prosecution
55 currently pending
Career history
185
Total Applications
across all art units

Statute-Specific Performance

§101
3.1%
-36.9% vs TC avg
§103
40.8%
+0.8% vs TC avg
§102
21.7%
-18.3% vs TC avg
§112
21.4%
-18.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 123 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Current Status of 17/607,815 This Office Action is responsive to amended claims of 7/20/2026. A Markush Search exists for a compound of formula I-I. The search was extended to the compounds below. This compound reads on claims 1, 9, 15, 19, 35, 154, and 155. Claims 29, 34, 38, 42, 45-46, and 151 are withdrawn from consideration in accordance with Markush practice. Priority The instant application is a national stage entry of PCT/US2020/031029, filed 05/01/2020, which claims priority to U.S. Provisional applications 62/982,858 (filed 2/28/2020), 62/842,855 (filed 5/3/2019), 62/842,858 (filed 5/3/2019), and 62/842,861 (filed 5/3/2019). The instant claims find support from U.S. provisional application 62/982,858, filed 2/28/2020. Therefore, the effective filing date is 2/28/2020. Information Disclosure Statement The information disclosure statement (IDS) submitted on 7/24/2026 is in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statement is being considered by the examiner. Response to Arguments Applicants’ claim amendments and Remarks of 07/20/2026 are acknowledged and have been considered. Any rejection and/or objection not specifically addressed or modified below is herein withdrawn. In regard to the anticipatory rejection, this rejection is withdrawn due to applicants claim amendments. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 154 and 155 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by ACS (American Chemical Society, Chemical Abstract Service, RN: 2195655-59-1, First made available to the public March 22, 2018). ACS anticipates a compound with a CAS# of 2195655-59-1. This compound is a compound of formula I-I, wherein X is S, Y is CH, Z is CH, n is 1, s is 2, R1 is F, and R3 is -SO2R6 and R6 is CH3. This anticipates claims 154 and 155 (formula I-d). Claim(s) 154 and 155 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by ACS (American Chemical Society, Chemical Abstract Service, RN: 1646917-73-8, First made available to the public February 13, 2015). ACS anticipates a compound with a CAS# of 1646917-73-8. This compound is a compound of formula I-I, wherein X is S, Y is CH, Z is CH, n is 1, s is 1, R1 is F, and R3 is a 5 membered heterocyclyl. This anticipates claims 154 and 155 (formula I-a). Conclusion Claims 154, and 155 are rejected. Claims 1, 9, and 15 are allowable. The disposition of these claims is dependent upon not finding other prior art rejections in future Markush Search Extensions. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. /G.A.H./Examiner, Art Unit 1625 /Andrew D Kosar/Supervisory Patent Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Show 8 earlier events
Jul 16, 2025
Response Filed
Oct 28, 2025
Final Rejection mailed — §102
Jan 27, 2026
Response after Non-Final Action
Feb 27, 2026
Request for Continued Examination
Mar 09, 2026
Response after Non-Final Action
Apr 24, 2026
Non-Final Rejection mailed — §102
Jul 20, 2026
Response Filed
Oct 01, 2026
Final Rejection mailed — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

7-8
Expected OA Rounds
54%
Grant Probability
99%
With Interview (+46.0%)
2y 11m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 123 resolved cases by this examiner. Grant probability derived from career allowance rate.

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