Prosecution Insights
Last updated: July 17, 2026
Application No. 17/633,060

COMPOSITIONS FOR TRANSFECTING A NUCLEIC ACID MOLECULE INTO A CELL COMPRISING TRIAZOLE COMPOUNDS GRAFTED TO A CATIONIC POLYMER, AND THEIR APPLICATIONS

Final Rejection §112
Filed
Feb 04, 2022
Priority
Aug 05, 2019 — EU 19315083.6 +1 more
Examiner
OTTON, ALICIA L
Art Unit
1699
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Polyplus Transfection
OA Round
2 (Final)
65%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
74%
With Interview

Examiner Intelligence

Grants 65% — above average
65%
Career Allowance Rate
826 granted / 1270 resolved
+5.0% vs TC avg
Moderate +9% lift
Without
With
+9.1%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
51 currently pending
Career history
1305
Total Applications
across all art units

Statute-Specific Performance

§101
0.5%
-39.5% vs TC avg
§103
34.3%
-5.7% vs TC avg
§102
24.6%
-15.4% vs TC avg
§112
13.9%
-26.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1270 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Remarks and Amendments Applicant’s amendments filed February 23, 2026 have been entered. All rejections and objections not explicitly maintained herein are withdrawn. The rejections below constitute the full set of rejections being applied to the instant claims. With regard to the objections to the abstract and specification, the objections are overcome by the amendments. With regard to the rejection of claims 1-15 under 35 USC 112(a) as being non-enabled across the entire scope of Formula III, the rejection is withdrawn in view of the claims amendments which narrow the scope of the claimed compounds. With regard to the rejections of claims 1-18 under 35 USC 112(b) for being indefinite, the rejections are overcome in view of the claim amendments to remove recitations of “preferably” and correct the antecedent basis issue. With regard to the rejection of claim 1 and 4-15 under 35 USC 102(a)(1), the rejection is withdrawn in view of the claim amendment to narrow the scope of the claimed compounds such that a grafted polyethyleneimine cationic polymer is required. The prior art does not teach or fairly suggest this requirement and the rejection no longer applies. Election/Restrictions In accordance with the MPEP, if upon examination of the elected species, no prior art is found that would anticipate or render obvious the instant invention based on the elected species, the search of the Markush-type claim will be extended (see MPEP 803.02). If prior art is then found that anticipates or renders obvious the non-elected species, the Markush-type claim will be rejected. It should be noted that the prior art search will not be extended unnecessarily to cover all non-elected species. Should Applicant overcome the rejection by amending the claim, the amended claim will be reexamined. Id. The prior art search will be extended to the extent necessary to determine patentability of the Markush-type claim. Id. In the event prior art is found during reexamination that renders obvious or anticipates the amended Markush-type claim, the claim will be rejected and the action made final. Id. As indicated in the previous action, the examiner searched the compound based on the elected species, wherein: no prior art was discovered over the elected species. The search and consideration was expanded to include the compounds described in the previous action. In view of the present claim amendments, the scope of the search and consideration was again expanded, ultimately resulting in a search of the full scope of the claimed compositions. Since the full scope has been searched, the election of species requirement is no longer in effect. Claim 1 is directed to an allowable product. Pursuant to the procedures set forth in MPEP § 821.04(B), claims 19-26, directed to the process of making or using an allowable product, previously withdrawn from consideration as a result of a restriction requirement, are hereby rejoined and fully examined for patentability under 37 CFR 1.104. Because all claims previously withdrawn from consideration under 37 CFR 1.142 have been rejoined, the restriction requirement as set forth in the Office action mailed on May 12, 2025 is hereby withdrawn. In view of the withdrawal of the restriction requirement as to the rejoined inventions, applicant(s) are advised that if any claim presented in a divisional application is anticipated by, or includes all the limitations of, a claim that is allowable in the present application, such claim may be subject to provisional statutory and/or nonstatutory double patenting rejections over the claims of the instant application. Once the restriction requirement is withdrawn, the provisions of 35 U.S.C. 121 are no longer applicable. See In re Ziegler, 443 F.2d 1211, 1215, 170 USPQ 129, 131-32 (CCPA 1971). See also MPEP § 804.01. Status of the Claims Currently, claims 1-5 and 12-38 are pending in the instant application and are under consideration in the instant application. Claim Objections Claims 16-17 are objected to because in the most recently submitted claim document, several compound structures are blurry or illegible. For example, compounds 2.48, 2.54, 2.57 and 2.58 must be redrawn clearly in order to be properly chemically interpreted for any patent which issues from the instant application. Claim Rejections - 35 USC § 112 (b) The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 20 and 22-26 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claims 20 and 22-26, the claims either explicitly recite or depend on a claim that explicitly recites the phrase "preferably" or “such as” which render the claims indefinite. This is because it is unclear whether the limitation(s) following the phrase are part of the claimed invention. Specifically, it is unclear whether the limitations following the phrase “preferably” and “such as” are intended to further limit the claim or are merely exemplary. See MPEP § 2173.05(d). Thus, the claims do not clearly set forth the required limitations and are rejected as indefinite. Conclusion Claims 1-5, 12-15, 18-19, 21 and 27-38 are allowed in this action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Alicia L. Otton whose telephone number is (571)270-7683. The examiner can normally be reached Monday - Thursday 8:00 AM - 6:00 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Fereydoun Sajjadi can be reached at 571-272-3311. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ALICIA L OTTON/Primary Examiner, Art Unit 1699
Read full office action

Prosecution Timeline

Feb 04, 2022
Application Filed
Oct 22, 2025
Non-Final Rejection mailed — §112
Feb 23, 2026
Response Filed
Jun 03, 2026
Final Rejection mailed — §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
65%
Grant Probability
74%
With Interview (+9.1%)
2y 7m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1270 resolved cases by this examiner. Grant probability derived from career allowance rate.

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