Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA. Priority This application is a 371 of PCT/US2020/048666 (08/30/2020) PCT/US2020/048666 has PRO 62/894,683 (08/30/2019). Election /Restrictions Applicant's election with out traverse of Group III, claim 21, in the reply filed on 11/4/2025 is acknowledged. Groups I and II, claims 1-19, are withdrawn. Information Disclosure An IDS was not filed in this application. Applicant is reminded of the duty of disclosure as per 37 CFR 1.56 and detailed in MPEP § 2000. Drawings The drawings filed 2/24/22 are objected to for not conforming to the requirements of 37 CFR 1.84(u)(1) (“View numbers must be preceded by the abbreviation “FIG.” Where only a single view is used in an application to illustrate the claimed invention, it must not be numbered and the abbreviation “FIG.” must not appear.”). MPEP 608.02. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness . Claim 21 is rejected under 35 U.S.C. 103 as being unpatentable over Trau et al. ( US7338768 ) in view of Rogers et al. ( US20060286488 ) . Regarding Claim 21, Trau teaches a system for preparing a combinatorial library with fluorescent encoding in a combinatorial synthesis (This invention relates generally to carrier-reporter bead assemblies and their use in relation to oligomer libraries which may be formed by a combinatorial split-process-recombine procedure, Col. 1, Lns . 13-15) , the system comprising: a) providing a set of labelling beads comprised of a plurality of labeling bead types, each labelling bead type being adapted to attach to the surface of a carrier bead or be captured in the bulk of a carrier bead, each labelling bead type having unique fluorescent label which is optically resolvable from the unique fluorescent label of other labelling bead type when attached to the surface of a carrier bead or captured in the bulk of a carrier bead; wherein: the unique f luorescent label on each labelling bead type comprises one, two or more fluorescence emission bands and one, two or more fluorescence excitation bands, each fluorescence emission band being distinguishable by one, two or more of: ( i ) the representative wavelength of emission, (ii) the intensity of emission, (iii) the characteristic wavelength of the excitation band exciting the emission, and (iv) the efficiency of excitation in this excitation band exciting the emission; and the unique fluorescent label on each labelling bead type is spectrally distinct from the unique fluorescent label on the other labelling bead types in the set of labelling beads, such that the plurality of labelling bead types, in combination, are each uniquely labelled ( “ Generally, for a split-process-recombine procedure with m steps and n processes, a set of mxn batches of reporter beads is sufficient to uniquely tag the entire process. In the above example, we showed how 16 unique tags could be produced from a combination of 4 fluorescent dyes. This number can be vastly increased by a number of simple schemes: (I) Increase the number of fluorescent dyes, with distinct fluorescent signals, incorporated inside the reporter particle .... (Ill) The concentration of fluorescent dye within each reporter bead can be varied. Different concentrations will give rise to different emission intensities (e.g., two different dye concentrations within the reporter beads will double the number of possible tags) ” , Col. 14, Ln. 65 - Col. 15, Ln. 42 ; “Carrier-reporter bead assemblies”, Title; claim 1 ); b) providing a plurality of carrier beads ( “ According to one aspect of the invention, there is provided an assembly of a carrier having on e or more reporter beads non-covalently attached thereto. … According to yet another aspect of the invention, there is provided a method for forming a synthetic oligomer library comprising a plurality of molecules comprising a multiplicity of different chemical groups, said method including the steps of: ... ( i ) attaching a respective chemical group to a carrier in each of a plurality of reaction vessels ” , Col. 4, Lns . 20 -39); c) providing a set of molecular building blocks for a combinatorial synthesis, the combinatorial synthesis having a plurality of steps, and each step of the combinatorial synthesis having a molecular building block, each building block being the same or different ( “ (ii) attaching a reporter bead to the carrier in non-covalent manner in each reaction vessel wherein each reporter bead has a marker associated therewith ” , Col. 4, Lns . 40-42); d) performing a sequence of steps of the combinatorial synthesis on a group of carrier beads, the sequence of steps comprising adding a new molecular building block to a group of carrier beads at each step of the combinatorial synthesis to form the combinatorial library, each group of carrier beads in the library having a unique synthetic compound ( “ (iii) combining the carriers from each reaction vessel resulting from steps ( i ) and (ii) into a recombination vessel; (iv) splitting the carriers from the recombination vessel into the plurality of reaction vessels wherein steps ( i ) and (ii) are repeated; and (v) repeating steps (iii) and (iv) until the library of molecules is formed wherein each molecule will have a unique signal associated therewith which signal is dependent on different combinations of markers to facilitate direct identification of the sequence of chemical groups comprising said molecule ” , Col. 4, Lns . 43-54); e) matching each molecular building block bound to the group carrier beads in a given sequence step of the combinatorial synthesis with a labelling bead type, thereby forming a population of different carrier bead groups, each carrier bead group having a unique synthetic molecule and corresponding unique fluorescent label encoded on the carrier bead, the unique fluorescent label being produced by the plurality of different labelling bead types, each with unique fluorescent labels, attached to the surface of the carrier beads in consecutive steps of the combinatorial synthesis ( “ Carriers tagged with red and blue reporters correspond to the peptide sequence Arginine-Glycine-carrier; carriers tagged with green and blue correspond to the sequence Arginine-Alanine-carrier; carriers tagged with green and yellow/red correspond to the sequence Lysine-Alanine-carrier and carriers tagged with red and yellow/red reporters correspond to the peptide sequence Lysine-Glycine-carrier ” , Col. 19, Ln. 65 - Col. 20, Ln. 4); f) identifying the labelling bead types attached to each carrier bead by an optical interrogation technique, wherein the unique fluorescent label on at least one labelling bead type is identifiable with an optical interrogation technique, and wherein the carrier beads are optically interrogated and the diameter of the smallest optically resolved region is smaller than the diameter of the carrier beads ( “ The invention in another aspect also includes a process of decoding molecules which are encoded by the process of the invention which includes the step of analysis of the reporter beads as described hereinafter so as to determine the unique sequence of the chemical groups which comprise each of the molecules ” , Col. 7, Lns . 17-22). Although Trau teaches identifying the beads by fluorescence optical microscopy (Col. 10, lines 52-54), Trau does not explicitly disclose optically interrogat ion with three-dimensional (3D) resolution . Rogers teaches using a 3D resolution optical interrogation technique to measure the diameter of beads ( [0006]: “ The present invention provides methods, devices and device components for fabricating 3D structures and patterns of 3D structures ” ; [0110]: “ The series of images collected with a confocal microscope reveals the full 3D shape of this polymer nanostructure ” ; [0112]: “ For the structures in FIGS. 7A-L, the finest features (i.e. post diameters, line widths; see red arrow) have dimensions of ~ 100 nm; and in certain cases features as small as 50 nm may be achieved ”) . It would have been obvious to one of ordinary skill in the art at the time of the invention to modify Trau with the teaching of Rogers for the purpose of using 3D-resolution techniques such as confocal microscopy to determine the 3D properties of beads such as their diameter to assess their suitability for use as carrier beads of labeled beads. T he level of skill in the art is very high such that one of ordinary skill in the art would consider routine the combination of elements from the teaching of the art. One of ordinary skill in the art would have recognized that the results of the combination would be predictable due to the well-known nature and optimizations routinely performed in the art. Thus, one of ordinary skill in the art would have arrived at the invention as claimed before the effective filing date with a reasonable expectation of success. Conclusion No claims allowed. 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