Office Action Predictor
Application No. 17/722,123

ELUTION OF MICROPARTICLES BY SIZE EXCLUSION CHROMATOGRAPHY USING WATER AS A MOBILE PHASE

Final Rejection §DP
Filed
Apr 15, 2022
Examiner
TICHY, JENNIFER M.H.
Art Unit
1653
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Pioma, INC.
OA Round
6 (Final)
65%
Grant Probability
Favorable
7-8
OA Rounds
3y 2m
To Grant
99%
With Interview

Examiner Intelligence

65%
Career Allow Rate
394 granted / 605 resolved
Without
With
+34.3%
Interview Lift
avg trend
3y 2m
Avg Prosecution
77 pending
682
Total Applications
career history

Statute-Specific Performance

§101
3.8%
-36.2% vs TC avg
§103
36.0%
-4.0% vs TC avg
§102
20.2%
-19.8% vs TC avg
§112
29.2%
-10.8% vs TC avg
Black line = Tech Center average estimate • Based on career data

Office Action

§DP
DETAILED ACTION The present application is being examined under the pre-AIA first to invent provisions. This Office Action is in response to the paper filed 16 June 2025. Claims 26-30, 33-37, 39, 41, and 43 are currently pending and under examination. This application is a Continuation application of U.S. Application No. 15/277982, filed September 27, 2016, which is a Divisional application of U.S. Application No. 13/838895, filed March 15, 2013, now U.S. Patent No. 9,493,910, which claims priority to U.S. Provisional Application No. 61/656945, filed June 7, 2012. Maintenance of Rejections: Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13. The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer. Claims 26, 39, 40, and 43 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1, 2, 7, and 8 of U.S. Patent No. 11,835,530. Although the claims at issue are not identical, they are not patentably distinct from each other because both encompass a method that includes eluting microparticles, which include exosomes and microvesicles, from cells by loading a blood sample, including plasma or serum, onto a size exclusion chromatography column and using water as the mobile phase (Instant claims: 26, 39, 40, 43; Cited Paten claims: 1, 2, 7, 8). Response to Arguments Applicant urges that the double patenting rejection is improper because the method of the pending claims is not the essence of the invention claimed in the independent claim of the reference patent. The Notice of Allowance of the reference patent does not identify dependent claim 2, using water as a liquid phase for SEC, in the reasons for allowance. Additionally, the pending claims of the present application are directed to the elution of microparticles as a standalone process, independent of any specific diagnostic application. Applicant’s arguments have been fully considered, but have not been found persuasive. As noted previously, a nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). Here, if the cited patent was available as prior art, an anticipation or obviousness rejection could be made over pending claims 26, 39, 40, and 43 using cited patent claims 1, 2, 7, and 8. As such, a nonstatutory double patenting rejection is appropriate. The mentioned essence of the inventions, reasons for allowance of the cited patent, and the fact that the present claims may be used as a standalone process, are not relevant to the determination of nonstatutory double patenting as set forth. Conclusion No claims are allowable. However, the claims appear to be free of the art. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JENNIFER M.H. TICHY whose telephone number is (571)272-3274. The examiner can normally be reached Monday-Thursday, 9:00am-7:00pm ET. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Sharmila G. Landau can be reached at (571)272-0614. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JENNIFER M.H. TICHY/Primary Examiner, Art Unit 1653
Read full office action

Prosecution Timeline

Apr 15, 2022
Application Filed
Apr 15, 2022
Response after Non-Final Action
Jun 16, 2022
Non-Final Rejection — §DP
Sep 21, 2022
Response Filed
Oct 14, 2022
Final Rejection — §DP
Dec 20, 2022
Response after Non-Final Action
Dec 28, 2022
Response after Non-Final Action
Jan 06, 2023
Applicant Interview (Telephonic)
Jan 20, 2023
Request for Continued Examination
Jan 29, 2023
Response after Non-Final Action
Feb 28, 2023
Examiner Interview Summary
Feb 28, 2023
Applicant Interview (Telephonic)
Jun 12, 2023
Non-Final Rejection — §DP
Nov 07, 2023
Examiner Interview Summary
Nov 07, 2023
Applicant Interview (Telephonic)
Nov 10, 2023
Examiner Interview Summary
Nov 10, 2023
Applicant Interview (Telephonic)
Nov 16, 2023
Response Filed
Mar 04, 2024
Final Rejection — §DP
Jun 05, 2024
Examiner Interview Summary
Jun 05, 2024
Applicant Interview (Telephonic)
Jun 10, 2024
Request for Continued Examination
Jun 13, 2024
Response after Non-Final Action
Dec 11, 2024
Non-Final Rejection — §DP
Jun 13, 2025
Response Filed
Sep 29, 2025
Final Rejection — §DP (current)

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Prosecution Projections

7-8
Expected OA Rounds
65%
Grant Probability
99%
With Interview (+34.3%)
3y 2m
Median Time to Grant
High
PTA Risk
Based on 605 resolved cases by this examiner