DETAILED ACTION
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after allowance or after an Office action under Ex Parte Quayle, 25 USPQ 74, 453 O.G. 213 (Comm'r Pat. 1935). Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, prosecution in this application has been reopened pursuant to 37 CFR 1.114. Applicant's submission filed on 04/06/2026 has been entered.
Applicant's amendment, filed 08/08/2025, has been entered.
Claims 35-95 are pending.
The New Grounds of Rejections are necessitated by Applicant’s IDS, filed 04/06/2026.
Information Disclosure Statement
The information disclosure statement (IDS) submitted on 04/06/2026 has been considered by the examiner.
There are numerous references in the IDS without a date and therefore have been crossed out and not been considered.
Claim Rejections - 35 USC § 102
In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status.
The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action:
A person shall be entitled to a patent unless –
(a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention.
Claims 35-95 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by An et al. (NPL #3 cited in IDS, filed 04/06/2026).
An et al. disclosed a bispecific antibody that binds alpha-synuclein and IGF1R, ABL301 (see page 2). Given that the reference disclosed Applicant’s own work, ABL301 would have the same sequences as that recited in the present claims. Moreover, An et al. disclosed that ABL301 comprises Grabody for penetrating BBB, a feature of the claimed invention as disclosed in the instant specification (e.g., Figures 3, 4 and 6). Given that the antibody is for therapeutic use, it would be in a pharmaceutical composition with a pharmaceutically acceptable carrier.
Any inquiry concerning this communication or earlier communications from the examiner should be directed to SHARON X WEN whose telephone number is (571)270-3064. The examiner can normally be reached Mon-Fri 8-5.
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If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Misook Yu can be reached at 571-272-0839. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/SHARON X WEN/Primary Examiner, Art Unit 1641
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