Prosecution Insights
Last updated: May 29, 2026
Application No. 17/769,483

METHOD FOR PRODUCING BICYCLIC PHOSPHORAMIDITE

Non-Final OA §103
Filed
Apr 15, 2022
Priority
Oct 18, 2019 — JP 2019-191053 +1 more
Examiner
LEWIS, PATRICK T
Art Unit
1691
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Daiichi Sankyo Company Limited
OA Round
2 (Non-Final)
74%
Grant Probability
Favorable
2-3
OA Rounds
0m
Est. Remaining
89%
With Interview

Examiner Intelligence

Grants 74% — above average
74%
Career Allowance Rate
851 granted / 1146 resolved
+14.3% vs TC avg
Moderate +14% lift
Without
With
+14.5%
Interview Lift
resolved cases with interview
Typical timeline
2y 3m
Avg Prosecution
25 currently pending
Career history
1176
Total Applications
across all art units

Statute-Specific Performance

§101
2.2%
-37.8% vs TC avg
§103
55.8%
+15.8% vs TC avg
§102
19.4%
-20.6% vs TC avg
§112
12.5%
-27.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1146 resolved cases

Office Action

§103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Applicant’s Response Dated July 23, 2025 In the Response dated July 23, 2025, claims 1, 9, 24, 39, 71, 87, 99, 109, 110, and 112-118 were amended. Claims 1, 7-9, 24, 39, 52, 57, 71, 87, 99, and 109-118 are pending. An action on the merits of claims 1, 7-9, 24, 39, 52, 57, 71, 87, 99, and 109-118 is contained herein. The rejection of claims 99 and 109-111 under 35 U.S.C. 112(b) has been withdrawn in view of applicant’s argument(s) or rendered moot in view of applicant’s amendment dated July 23, 2025. The rejection of claims 1 and 7-9 under 35 U.S.C. 103 as being unpatentable over Wengel US 6,794,499 B2 is maintained for the reasons of record as set forth in the Office Action dated May 19, 2025. Rejections Set Forth in the Office Action Dated May 19, 2025 The text of those sections of Title 35, U.S. Code not included in this action can be found in a prior Office action. Claims 1 and 7-9 are rejected under 35 U.S.C. 103 as being unpatentable over Wengel US 6,794,499 B2. Applicant's arguments filed July 23, 2025 have been fully considered but they are not persuasive. Applicant submits that there is no teaching in the prior art that would have suggested the crystalline ENA intermediates of the present disclosure or the advantages of using these crystalline ENA intermediates in the synthesis of ENAs compared to known ENA syntheses. Applicant’s arguments have been fully considered but are not persuasive. The patentability of a product does not depend on its method of production (e.g., intermediate(s)). If the product in is the same as or obvious from a product of the prior art, the claim is unpatentable even though the prior product was made by a different process. Thus, the rejection is maintained based on the preponderance of evidence. Conclusion Claims 1, 7-9, 24, 39, 52, 57, 71, 87, 99, and 109-118 are pending. Claims 1 and 7-9 are rejected. Claims 24, 39, 52, 57, 71, 87, 99, and 109-118 are allowed. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Contacts Any inquiry concerning this communication or earlier communications from the examiner should be directed to PATRICK T LEWIS whose telephone number is (571)272-0655. The examiner can normally be reached Monday to Friday, 10 AM to 4 PM EST (Maxi Flex). Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Shaojia Jiang can be reached at (571) 272-0627. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /PATRICK T LEWIS/Primary Examiner, Art Unit 1691 /PL/
Read full office action

Prosecution Timeline

Show 1 earlier event
May 19, 2025
Non-Final Rejection mailed — §103
Jul 23, 2025
Response Filed
Oct 09, 2025
Final Rejection mailed — §103
Feb 05, 2026
Response after Non-Final Action
Apr 06, 2026
Applicant Interview (Telephonic)
Apr 06, 2026
Examiner Interview Summary
Apr 09, 2026
Request for Continued Examination
Apr 13, 2026
Response after Non-Final Action

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
74%
Grant Probability
89%
With Interview (+14.5%)
2y 3m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1146 resolved cases by this examiner. Grant probability derived from career allowance rate.

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