Prosecution Insights
Last updated: April 19, 2026
Application No. 17/786,175

BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT

Non-Final OA §102§DP
Filed
Jun 16, 2022
Examiner
CHONG, YONG SOO
Art Unit
1623
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Agenebio Inc.
OA Round
1 (Non-Final)
44%
Grant Probability
Moderate
1-2
OA Rounds
3y 8m
To Grant
84%
With Interview

Examiner Intelligence

Grants 44% of resolved cases
44%
Career Allow Rate
378 granted / 862 resolved
-16.1% vs TC avg
Strong +40% interview lift
Without
With
+40.1%
Interview Lift
resolved cases with interview
Typical timeline
3y 8m
Avg Prosecution
66 currently pending
Career history
928
Total Applications
across all art units

Statute-Specific Performance

§101
0.4%
-39.6% vs TC avg
§103
44.3%
+4.3% vs TC avg
§102
18.5%
-21.5% vs TC avg
§112
14.2%
-25.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 862 resolved cases

Office Action

§102 §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Status of the Application Applicant's election without traverse of Group I, drawn to a compound of formula A, and the species election (compound 731) in the reply filed 1/16/26 is acknowledged. Claims 1-23 are pending. Claims 12-23 have been withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Claim 3 has been withdrawn from further consideration as being drawn to a non-elected species. Claims 1-2, 4-11 are examined herein insofar as they read on the elected invention and species. A search has been performed on the species election and found free of the prior art, therefore allowable. A new species will be elected from the genus of formula A for further examination. Claims 2-3, 5 has been withdrawn from further consideration as being drawn to a non-elected species. Claims 1, 4, 6-11 are examined herein insofar as they read on the elected invention and species. Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13. The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer. Claims 1-4, 6-11 are rejected on the ground of nonstatutory double patenting as being unpatentable over the following: claims 1-40 of U.S. Patent No. 10,329,301 claims 1-10 of U.S. Patent No. 11,312,721 claims 1-51 of U.S. Patent No. 11,414,425 claims 1-22 of U.S. Patent No. 11,505,555 claims 1-22 of U.S. Patent No. 12,024,525 claims 1-37 of U.S. Patent No. 12,291,535 claims 1-11 of U.S. Patent No. 12,528,819. Although the claims at issue are not identical, they are not patentably distinct from each other because the referenced claims recite a compound that reads on the instant formula A. Claims 1-4, 6-11 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1, 3-4, 7-8, 11, 14, 17, 20, 22-25, 30, 45-46, 61-62, 64-65, 67-68 of copending Application No. 18,235,753. Although the claims at issue are not identical, they are not patentably distinct from each other because the referenced claims recite a compound that reads on the instant formula A. This is a provisional obviousness-type double patenting rejection because the conflicting claims have not in fact been patented. Claims 1-4, 6-11 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1, 7, 9, 15, 21-22, 27-28, 34, 37, 41-42, 58-59, 61-62, 64-67 of copending Application No. 18,852,724. Although the claims at issue are not identical, they are not patentably distinct from each other because the referenced claims recite a compound that reads on the instant formula A. This is a provisional obviousness-type double patenting rejection because the conflicting claims have not in fact been patented. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale or otherwise available to the public before the effective filing date of the claimed invention. Claims 1, 4, 6-11 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Mekonnen et al. (US Patent Application 2018/0170941, of record). Mekonnen et al. teach benzodiazepine derivatives and methods of treating cognitive impairment associated with central nervous system disorders (abstract). A preferred benzodiazepine derivative is compound 328 (below) (claims 4, 28) in combination with a pharmaceutically acceptable carrier, adjuvant, vehicle (claim 5), antipsychotic, memantine (claim 7), donepezil (claim 10), and aripiprazole (claim 40) to form a pharmaceutical composition. PNG media_image1.png 170 322 media_image1.png Greyscale Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to Yong S. Chong whose telephone number is (571)-272-8513. The examiner can normally be reached Monday to Friday: 9 AM to 5 PM EST. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Adam Milligan, can be reached at (571)-270-7674. The fax phone number for the organization where this application or proceeding is assigned is (571)-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at (866)-217-9197 (toll-free). /Yong S. Chong/Primary Examiner, Art Unit 1623
Read full office action

Prosecution Timeline

Jun 16, 2022
Application Filed
Mar 12, 2026
Non-Final Rejection — §102, §DP (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
44%
Grant Probability
84%
With Interview (+40.1%)
3y 8m
Median Time to Grant
Low
PTA Risk
Based on 862 resolved cases by this examiner. Grant probability derived from career allow rate.

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