Prosecution Insights
Last updated: April 19, 2026
Application No. 17/789,403

Polymer Formulations for Anti-fouling Hydrogel Coatings

Non-Final OA §102§103
Filed
Jun 27, 2022
Examiner
QIAO, HUIHONG
Art Unit
1763
Tech Center
1700 — Chemical & Materials Engineering
Assignee
The Board Of Trustees Of The Leland Stanford Junior University
OA Round
3 (Non-Final)
71%
Grant Probability
Favorable
3-4
OA Rounds
3y 3m
To Grant
94%
With Interview

Examiner Intelligence

Grants 71% — above average
71%
Career Allow Rate
77 granted / 109 resolved
+5.6% vs TC avg
Strong +24% interview lift
Without
With
+23.9%
Interview Lift
resolved cases with interview
Typical timeline
3y 3m
Avg Prosecution
44 currently pending
Career history
153
Total Applications
across all art units

Statute-Specific Performance

§101
0.3%
-39.7% vs TC avg
§103
52.0%
+12.0% vs TC avg
§102
17.0%
-23.0% vs TC avg
§112
18.0%
-22.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 109 resolved cases

Office Action

§102 §103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . This communication is responsive to the claim set filed 11/12/2025. Claims 1-7 are pending and under examination. The 35 USC 102 and 103 rejections based on Mika et al. (US2008/0262867 A1) dated 07/14/2025 are WITHDRAWN due to Applicant’s amendments. Claims 1-7 are rejected for the reasons set forth below. The text of those sections of Title 35, U.S. Code not included in this action can be found in a previous Office Action. Continued Examination A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on 11/20/2025 has been entered. Claim Rejections - 35 USC § 102 Claims 1 and 5 are rejected under 35 U.S.C. 102 (a) (1) as being anticipated by Nagamine et al. (RSC Adv., 2015, 5, 66334) Nagamine teaches anti-fouling surface of the stretchable double network (DN) hydrogel composed of poly(2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt) (PNaAMPS) and poly(N,N-dimethylacrylamide) (ab.). Thus, Nagamine teaches anti-fouling hydrogel comprising a polymer of 100% N,N-dimethylacrylamide. Claim Rejections - 35 USC § 103 Claims 1-7 are rejected under 35 U.S.C. 103 as being unpatentable over Yahiaoui et al. (US8,545,951 B2). Regarding Claims 1 and 5, Yahiaoui teaches a hydrogel layer compositing a hydrogel polymer which is made from one or more monomers include acrylamido methyl propane sulfonic acid (instant monomer J), acrylamide (instant monomer A) and dimethylacrylamide (instant monomer B) (2:35-45). In view of such teaching, it would have been obvious to one skilled artisan in the field before the effective filing date of instant application to have a hydrogel comprising a polymer of dimethylacrylamide or a copolymer of the combination of two ore more monomers of A, B and J. Yahiaoui further teaches the hydrogel is part of an anti-fouling treatment article (claim 1). Additionally, “anti-fouling” in the preambles describes the intended use rather than the structure of the apparatus. In other words, the limitations of “anti-fouling” is not positively recited structures of the claims and it does not receive patentable weight (see MPEP 2111.02(II)). Regarding Claims 2 and 6, as discussed in Claim 1 and Claim 5, Yahiaoui teaches a hydrogel layer comprising a claimed polymer or copolymer; therefore, the anti-fouling properties are expected. "Products of identical chemical composition cannot have mutually exclusive properties." A chemical composition and its properties are inseparable. Therefore, if the prior art teaches the identical chemical structure, the properties applicant discloses and/or claims are necessarily present (See MPEP 2112.01 II). In this case, monomer A, B and J are more structurally similar to amino acid blocks of proteins than PEG, consequently, the polymer or copolymers should repel protein adsorption better than PEG does. Regarding Claims 3 and 7, the anti-fouling surface treatment, which comprises the hydrogel layer, is used for medical devices, such as catheters (1:65 to 2:5) to prevent fouling caused by contacting with blood or bodily fluids (background and summary). Regarding Claim 4, Yahiaoui teaches a hydrogel polymer which is made from one or more monomers include acrylamido methyl propane sulfonic acid (instant monomer J), acrylamide (instant monomer A) and dimethylacrylamide (instant monomer B) (2:35-45). One ordinary skilled artisan would reasonably infer a polymer of dimethylacrylamide or a copolymer of two or three of the three monomers. Response to Arguments Applicant’s arguments with respect to claims 1 and 5 have been considered but are moot because the new ground of rejection does not rely on any reference applied in the prior rejection of record for any teaching or matter specifically challenged in the argument. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to HUIHONG QIAO whose telephone number is (571)272-8315. The examiner can normally be reached 9AM - 5PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Joseph Del Sole can be reached at 571-272-1130. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /HUIHONG QIAO/ Examiner, Art Unit 1763 /CATHERINE S BRANCH/ Primary Examiner, Art Unit 1763
Read full office action

Prosecution Timeline

Jun 27, 2022
Application Filed
Dec 18, 2024
Non-Final Rejection — §102, §103
Apr 04, 2025
Response Filed
Jul 09, 2025
Final Rejection — §102, §103
Nov 12, 2025
Response after Non-Final Action
Nov 20, 2025
Request for Continued Examination
Nov 21, 2025
Response after Non-Final Action
Dec 23, 2025
Non-Final Rejection — §102, §103
Mar 23, 2026
Response Filed

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
71%
Grant Probability
94%
With Interview (+23.9%)
3y 3m
Median Time to Grant
High
PTA Risk
Based on 109 resolved cases by this examiner. Grant probability derived from career allow rate.

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