Prosecution Insights
Last updated: April 19, 2026
Application No. 17/911,878

COMPOSITE PARTICLES FOR BIOLOGIC ASSAY

Non-Final OA §103
Filed
Sep 15, 2022
Examiner
OYER, ANDREW J
Art Unit
1767
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Nexdot
OA Round
1 (Non-Final)
79%
Grant Probability
Favorable
1-2
OA Rounds
2y 7m
To Grant
96%
With Interview

Examiner Intelligence

Grants 79% — above average
79%
Career Allow Rate
467 granted / 589 resolved
+14.3% vs TC avg
Strong +16% interview lift
Without
With
+16.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
32 currently pending
Career history
621
Total Applications
across all art units

Statute-Specific Performance

§101
1.8%
-38.2% vs TC avg
§103
36.2%
-3.8% vs TC avg
§102
20.8%
-19.2% vs TC avg
§112
24.5%
-15.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 589 resolved cases

Office Action

§103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Claims 20-24 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a nonelected inventions, there being no allowable generic or linking claim. Applicant timely traversed the restriction (election) requirement in the reply filed on 2 October 2025. Applicant's election with traverse of Group I, claims 12-19, in the reply filed on 2 October 2025 is acknowledged. The traversal is on the ground(s) that the ISA considered the same prior art and did not determine the unity of invention to be lacking. However, this is not found persuasive because the ISA’s determinations of unity or lack of unity does not control the USPTO’s determination of unity of invention. The requirement is still deemed proper and is therefore made FINAL. Information Disclosure Statement The information disclosure statement (IDS) submitted on 15 September 2022 was filed. The submission is in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statement has been considered by the Office. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claims 12-19 are rejected under 35 U.S.C. 103 as being unpatentable over Cao et al. (WO 2018/220160, from the IDS filed 15 September 2022, hereinafter referred to as “Cao”). As to Claim 12: Cao teaches a composite particle comprising a plurality of nanoparticles encapsulated in an inorganic material (Abstract). Cao does not explicitly teach an example having all the recited features. However, Cao teaches that the nanoparticles can selectively emit green light (Pg. 86, Lines 10-13). Cao further teaches that the nanoparticles can have a smallest size of about 1 nm (Pg. 93, Lines 1-2) and the nanoparticles can represent about 14% of the composite particles (Pg. 107, Lines 11-14). Cao further teaches that the inorganic matrix material can be 100% Al2O3 (Pg. 82, Lines 24-26). Additionally, Cao teaches that the composite particle can be functionalized with a specific-binding component (Pg. 137, Lines 19-20). Cao further teaches that the composite particles can have a size of 150 nm (Pg. 14, Lines 27-32). At the time of filing, it would have been obvious to a person having ordinary skill in the art to select these features from the teachings of Cao because Cao teaches that each of these features are suitable for use in a composite particle comprising a plurality of nanoparticles encapsulated in an inorganic material (Abstract). As to Claim 13: Cao teaches the composite particle according to claim 12 (supra). Cao further teaches that the nanoparticles can be metals or metallic alloys (Pg. 116, Lines 11-14) and that the nanoparticles is a plasmonic nanoparticle (Pg. 88, Line 2). As to Claim 14: Cao teaches the composite particle according to claim 12 (supra). Cao further teaches that the nanoparticles are preferably luminescent semiconductor (i.e., inorganic) nanocrystals (Pg. 4, Lines 1-5). As to Claim 15 and 16: Cao teaches the composite particle according to claim 12 (supra). Cao further teaches one dimension of the nanoparticles can be 3 nm (Pg. 93, Lines 1-2). As to Claim 17: Cao teaches the composite particle according to claim 12 (supra). Cao further teaches the nanoparticles can be nanodisks (Pg. 125, Lines 4-5). As to Claim 18: Cao teaches the composite particle according to claim 12 (supra). Cao further teaches that the composite particles can contain two different luminescent nanoparticles with different emission wavelengths (Pg. 103, Lines 12-13). As to Claim 19: Cao teaches the composite particle according to claim 12 (supra). Cao further teaches that the matrix can be Al2O-3 (Pg. 82, Lines 24-26) Correspondence Any inquiry concerning this communication or earlier communications from the examiner should be directed to ANDREW J OYER whose telephone number is (571)270-0347. The examiner can normally be reached 9AM-6PM EST M-F. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Mark Eashoo can be reached at (571)272-1197. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Andrew J. Oyer/Primary Examiner, Art Unit 1767
Read full office action

Prosecution Timeline

Sep 15, 2022
Application Filed
Jan 27, 2026
Non-Final Rejection — §103 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
79%
Grant Probability
96%
With Interview (+16.4%)
2y 7m
Median Time to Grant
Low
PTA Risk
Based on 589 resolved cases by this examiner. Grant probability derived from career allow rate.

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