Prosecution Insights
Last updated: April 19, 2026
Application No. 17/923,293

METHODS AND DEVICES FOR TREATMENT OF NEUROPATHY

Non-Final OA §102§103
Filed
Nov 04, 2022
Examiner
PRICE, NATHAN R
Art Unit
3783
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
University Of Maine System Board Of Trustees
OA Round
1 (Non-Final)
52%
Grant Probability
Moderate
1-2
OA Rounds
4y 4m
To Grant
92%
With Interview

Examiner Intelligence

Grants 52% of resolved cases
52%
Career Allow Rate
261 granted / 498 resolved
-17.6% vs TC avg
Strong +39% interview lift
Without
With
+39.3%
Interview Lift
resolved cases with interview
Typical timeline
4y 4m
Avg Prosecution
50 currently pending
Career history
548
Total Applications
across all art units

Statute-Specific Performance

§101
1.2%
-38.8% vs TC avg
§103
39.6%
-0.4% vs TC avg
§102
31.4%
-8.6% vs TC avg
§112
20.3%
-19.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 498 resolved cases

Office Action

§102 §103
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Applicant’s election without traverse of Group II in the reply filed on 11/26/25 is acknowledged. Claims 1, 3-10, 12, 23, 24, 27-29, 31, 77, 81, and 82 are withdrawn from consideration. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 44, 46, 54, 64, and 65 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Mansoor et al. (US 20200078575). Regarding claim 44, Mansoor et al. discloses a device (fig. 1-5B) comprising: a substrate 12; and an array of needles 24 disposed on or through the substrate; wherein one or more of the needles is hollow through the entire length of the needle (par. 0060-0066); wherein the array is configured to allow fluid transport through at least one hollow needle of the array (par. 0060-0066); and wherein the array is configured to receive and communicate one or more electrical signals (par. 0064). Regarding claim 46, Mansoor et al. discloses one or more needles in the array further comprises a coating to penetrate skin to epidermis, dermis, or further beneath the skin (par. 0064, fig. 3A). Regarding claim 54, Mansoor et al. discloses one or more of the needles is a stimulating electrode (par. 0064, fig. 3A). Regarding claims 64 and 65, Mansoor et al. discloses a substrate/array configuration that is fully capable of being adjusted for different depths of penetration by a spacer (see structure in fig. 3A). Additionally, Mansoor et al. discloses utilizing a spacer (36; fig. 5A-B) which alters penetration depth of the needles (par. 0078). Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention. Claim(s) 47, 49, 50, and 55 is/are rejected under 35 U.S.C. 103 as being unpatentable over Mansoor et al. in view of Arias et al. (US 20020133129). Regarding claims 47, 49, 50, and 55, Mansoor et al. discloses the device as claimed, except for specifically disclosing one or more needles in the array comprise a coating to insulate an electrical signal, one or more needles in the array is coated with an electrically conductive material, one or more needles in the array is at least partially filled with an electrically conductive material, and/or one or more needles is a reference or ground electrode. However, Arias et al. teaches providing insulative coatings on microneedles (par. 0156), conductive coatings on microneedles (par. 0162), filling microneedles with an electrically conductive material (par. 0162), and/or utilizing a reference electrode (par. 0066). It would have been obvious to one having ordinary skill in the art before the effective filing date of the claimed invention to modify Mansoor et al. to utilize any combination of the structures of claims 47, 49, 50, and 55, as taught by Arias et al., since Arias et al. teaches that these structures are all options for fabricating/arranging microneedles in an electrically active array depending on their desired properties. Claim(s) 64 and 65, in the alternative, is/are rejected under 35 U.S.C. 103 as being unpatentable over Mansoor et al. in view of Hantash et al. (US 20070142885). Regarding claims 64 and 65, in the alternative to what is disclosed by Mansoor et al. as discussed under 35 U.S.C. 102 above, Hantash et al. teaches utilizing an adjustable spacer 106 to create a desired penetration depth for a needle array (par. 0071; fig. 13). It would have been obvious to one having ordinary skill in the art before the effective filing date of the claimed invention to modify the device of Mansoor et al. to utilize an adjustable spacer such as the one taught by Hantash et al. for the purpose of providing sufficient structure for the spacer to enable a variety of possible penetration depths as needed. Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure: O’Brien, III et al. (US 20170354810): energized needle array with spacer Unger et al. (US 20020099356): layered microneedle construction Any inquiry concerning this communication or earlier communications from the examiner should be directed to NATHAN R PRICE whose telephone number is (571)270-5421. The examiner can normally be reached Mon-Fri 8:00am-4:00pm Eastern time. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Michael Tsai can be reached at 571-270-5246. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /NATHAN R PRICE/Primary Examiner, Art Unit 3783
Read full office action

Prosecution Timeline

Nov 04, 2022
Application Filed
Dec 09, 2025
Non-Final Rejection — §102, §103 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
52%
Grant Probability
92%
With Interview (+39.3%)
4y 4m
Median Time to Grant
Low
PTA Risk
Based on 498 resolved cases by this examiner. Grant probability derived from career allow rate.

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