Prosecution Insights
Last updated: April 19, 2026
Application No. 17/924,198

USE OF SYMPATHETIC ACTIVATION INHIBITOR AND/OR ALPHA 1-ADRENERGIC RECEPTOR INHIBITOR IN PREPARING MEDICINE FOR TREATING DRY EYES

Non-Final OA §101§112
Filed
Nov 09, 2022
Examiner
HUANG, GIGI GEORGIANA
Art Unit
1613
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Eye Institute Of Shandong First Medical University
OA Round
1 (Non-Final)
32%
Grant Probability
At Risk
1-2
OA Rounds
3y 11m
To Grant
62%
With Interview

Examiner Intelligence

Grants only 32% of cases
32%
Career Allow Rate
192 granted / 602 resolved
-28.1% vs TC avg
Strong +30% interview lift
Without
With
+30.0%
Interview Lift
resolved cases with interview
Typical timeline
3y 11m
Avg Prosecution
44 currently pending
Career history
646
Total Applications
across all art units

Statute-Specific Performance

§101
0.7%
-39.3% vs TC avg
§103
39.5%
-0.5% vs TC avg
§102
12.4%
-27.6% vs TC avg
§112
25.0%
-15.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 602 resolved cases

Office Action

§101 §112
DETAILED ACTION Status of Application Claims 10-19 (first) and 19(second)- 29 are pending. Claims 10-19 (first) and 19(second)- 29 are present for examination at this time. The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Objections Claims 19 (first) and 19(second) are objected to because of the following informalities: There are two claims numbered as claim 19 which is incorrect. Appropriate correction is required. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 10-19 (first) and 19(second)- 29 are rejected under 35 U.S.C. 101 because the claimed invention is directed to non-statutory subject matter. The claims do not fall within at least one of the four categories of patent eligible subject matter because the claimed recitation of a use, without setting forth any steps involved in the process, results in an improper definition of a process, i.e., results in a claim which is not a proper process claim under 35 U.S.C. 101. It does not address if it is to a process, machine, manufacture, or composition of matter (the four categories of patent eligible subject matter). See for example Ex parte Dunki, 153 USPQ 678 (Bd.App. 1967) and Clinical Products, Ltd. v. Brenner, 255 F. Supp. 131, 149 USPQ 475 (D.D.C. 1966). See MPEP 2173.05(q). Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 10-19 (first) and 19(second)- 29 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claims 10-19 (first) and 19(second)- 23 provides for the use of a sympathetic activation inhibitor and/or an al-adrenergic receptor inhibitor in preparing a medicine for treating or relieving dry eye syndrome and dependent claims recite various dosage forms, and claims 24-29 provides for the use of a sympathetic activation inhibitor and/or an o.1-adrenergic receptor inhibitor in preparing a medicine for increasing tear secretion and/or reduce inflammation of a lacrimal gland and an ocular surface; but the claims does not set forth any recitations if it is for a composition with intended use or any steps involved for which method of treating or process of manufacture, it is unclear what method or process or composition of matter applicant is intending to encompass as it also recites both a use for preparing with a use for treating which are two different processes or if a composition with an intended use as it is unclear what statutory category the claims are directed to. See MPEP 2173.05(q). A claim is indefinite where it merely recites a use without any active, positive steps delimiting how this use is actually practiced. It does not allow one to ascertain the metes and bounds of the clams as written and cannot be further treated for prior art examination pending Applicant’s amendment to define which statutory category the claims are directed to with the requisite limitations. Conclusion Claims 10-19 (first) and 19(second)- 29 are rejected. Any inquiry concerning this communication or earlier communications from the examiner should be directed to GIGI GEORGIANA HUANG whose telephone number is (571)272-9073. The examiner can normally be reached Monday-Thursday 9:00-5:00pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Brian Kwon can be reached at 571-272-0581. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /GIGI G HUANG/Primary Examiner, Art Unit 1613
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Prosecution Timeline

Nov 09, 2022
Application Filed
Sep 19, 2025
Non-Final Rejection — §101, §112
Dec 23, 2025
Response Filed

Precedent Cases

Applications granted by this same examiner with similar technology

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ALLERGEN DESENSITIZATION METHOD
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Patent 12491179
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Patent 12419990
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2y 5m to grant Granted Sep 02, 2025
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
32%
Grant Probability
62%
With Interview (+30.0%)
3y 11m
Median Time to Grant
Low
PTA Risk
Based on 602 resolved cases by this examiner. Grant probability derived from career allow rate.

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