Office Action Predictor
Application No. 17/942,367

MTA-Cooperative PRMT5 Inhibitors

Final Rejection §112§DP
Filed
Sep 12, 2022
Examiner
LEESER, ERICH A
Art Unit
1622
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Mirati Therapeutics, INC.
OA Round
2 (Final)
82%
Grant Probability
Favorable
3-4
OA Rounds
2y 3m
To Grant
95%
With Interview

Examiner Intelligence

82%
Career Allow Rate
772 granted / 946 resolved
Without
With
+13.5%
Interview Lift
avg trend
2y 3m
Avg Prosecution
15 pending
961
Total Applications
career history

Statute-Specific Performance

§101
1.4%
-38.6% vs TC avg
§103
12.6%
-27.4% vs TC avg
§102
22.0%
-18.0% vs TC avg
§112
38.5%
-1.5% vs TC avg
Black line = Tech Center average estimate • Based on career data

Office Action

§112 §DP
DETAILED ACTION This action is in response to Applicant’s submission dated July 16, 2025, in which Applicant amended claims 51 and 53, added new claims 58-61, and canceled claims 1-50, 52, and 56-57. Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 112 The following is a quotation of the first paragraph of 35 U.S.C. 112(a): (a) IN GENERAL.—The specification shall contain a written description of the invention, and of the manner and process of making and using it, in such full, clear, concise, and exact terms as to enable any person skilled in the art to which it pertains, or with which it is most nearly connected, to make and use the same, and shall set forth the best mode contemplated by the inventor or joint inventor of carrying out the invention. Because Applicant limited all cancer down to specific cancers, Examiner withdraws this rejection. Double Patenting The non-statutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. See In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) may be used to overcome an actual or provisional rejection based on a non-statutory double patenting ground provided the conflicting application or patent is shown to be commonly owned with this application. See 37 CFR 1.130(b). Effective January 1, 1994, a registered attorney or agent of record may sign a terminal disclaimer. A terminal disclaimer signed by the assignee must fully comply with 37 CFR 3.73(b). Claims 51, 53-55, and 58-61 are rejected under the judicially created doctrine of obviousness-type double patenting as being unpatentable over claims 2-30 of Bobinski, et al., United States Patent No. 11,479,551. Although the conflicting claims are not identical, they are not patentably distinct from each other because the subject matter embraced in the instant claims is also embraced in United States Patent No. 11,479,551. The claims of the reference and the instant claims are obvious variants of one another because there is substantial overlap between instant L, X, Z, R2, R4, R5, R6, and their corresponding positions in the reference, as well as the laundry list of identical cancer types between the instant rejected claims and those of the reference. Applicant traverses this rejection by arguing that the “claims herein are not shown as patentably indistinct” without stating the deficiency in the outstanding double patenting rejection. As such, the outstanding double patenting rejection is hereby maintained. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Conclusion Any inquiry concerning this communication or earlier communications from the Examiner should be directed to ERICH A LEESER whose telephone number is (571) 272-9932. The Examiner can normally be reached Monday through Friday from 10-6 PST, M-F. PST. If attempts to reach the Examiner by telephone are unsuccessful, the Examiner’s supervisor, Mr. James Alstrum-Acevedo can be reached at (571) 272-5548. The fax number for the organization where this application is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) toll-free at 866-217-9197. If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ERICH A LEESER/Primary Examiner, Art Unit 1622 United States Patent and Trademark Office Tel. No.: (571) 272-9932
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Prosecution Timeline

Sep 12, 2022
Application Filed
Jan 29, 2025
Non-Final Rejection — §112, §DP
Jul 16, 2025
Response Filed
Aug 09, 2025
Final Rejection — §112, §DP
Apr 13, 2026
Response after Non-Final Action

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Prosecution Projections

3-4
Expected OA Rounds
82%
Grant Probability
95%
With Interview (+13.5%)
2y 3m
Median Time to Grant
Moderate
PTA Risk
Based on 946 resolved cases by this examiner