Prosecution Insights
Last updated: April 19, 2026
Application No. 17/966,782

COMPOSITIONS OF BERBERINE URSODEOXYCHOLATE AND METHODS THEREOF FOR TREATING FATTY LIVER DISEASE, DIABETES AND HYPERLIPIDEMIA

Non-Final OA §102
Filed
Oct 15, 2022
Examiner
WARD, PAUL V
Art Unit
1622
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Shenzhen Hightide Biopharmaceutical Ltd.
OA Round
1 (Non-Final)
83%
Grant Probability
Favorable
1-2
OA Rounds
2y 7m
To Grant
72%
With Interview

Examiner Intelligence

Grants 83% — above average
83%
Career Allow Rate
1391 granted / 1672 resolved
+23.2% vs TC avg
Minimal -11% lift
Without
With
+-11.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
36 currently pending
Career history
1708
Total Applications
across all art units

Statute-Specific Performance

§101
2.1%
-37.9% vs TC avg
§103
19.1%
-20.9% vs TC avg
§102
19.4%
-20.6% vs TC avg
§112
43.7%
+3.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1672 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION STATUS OF THE CLAIMS: Claims 1, 3-5, 8-9, 11-12, 24-26, 29-33, 38, 37-38 and 41 are pending in this application. Election/Restrictions Applicant's election of species in the reply filed on September 7, 2025 is acknowledged. All claims will be examined. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale or otherwise available to the public before the effective filing date of the claimed invention. Claims 1, 3-5, 8-9, 11-12, 24-26, 29-33, 38, 37-38 and 41 (including claims dependent thereon or relate back to other claims) are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Meng Yu et al. (WO2018/205987). This reference discloses compounds in paragraphs 5-9, 20, 23, 34-36, 102-107, 206, 209, 225-240 and 293-294. (See Abstract, claims and Tables). These compounds read on the instant claim. Since this reference teaches the exact compounds, Applicant’s claims are anticipated, and thus, rejected under 35 U.S.C. 102. Claims 1, 3-5, 8-9, 11-12, 24-26, 29-33, 38, 37-38 and 41 (including claims dependent thereon or relate back to other claims) are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Di Bisceglie’ et al., (J’nal of Hepatology’2020). This reference discloses compounds on pages S440-S441. (See Abstract and entire document). These compounds read on the instant claim. Since this reference teaches the exact compounds, Applicant’s claims are anticipated, and thus, rejected under 35 U.S.C. 102. Conclusion Claims 1, 3-5, 8-9, 11-12, 24-26, 29-33, 38, 37-38 and 41 are pending. Claims 1, 3-5, 8-9, 11-12, 24-26, 29-33, 38, 37-38 and 41 are rejected. No claims are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to PAUL V WARD whose telephone number is (571)272-2909. The examiner can normally be reached M-F 9am to 5pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, James Alstrum-Acevedo can be reached at 571-272-5548. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /PAUL V WARD/ Primary Examiner, Art Unit 1622
Read full office action

Prosecution Timeline

Oct 15, 2022
Application Filed
Nov 21, 2025
Non-Final Rejection — §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
83%
Grant Probability
72%
With Interview (-11.0%)
2y 7m
Median Time to Grant
Low
PTA Risk
Based on 1672 resolved cases by this examiner. Grant probability derived from career allow rate.

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