Prosecution Insights
Last updated: April 19, 2026
Application No. 17/967,344

NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE

Non-Final OA §102
Filed
Oct 17, 2022
Examiner
WARD, PAUL V
Art Unit
1622
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Oligomerix Inc.
OA Round
4 (Non-Final)
83%
Grant Probability
Favorable
4-5
OA Rounds
2y 7m
To Grant
72%
With Interview

Examiner Intelligence

Grants 83% — above average
83%
Career Allow Rate
1391 granted / 1672 resolved
+23.2% vs TC avg
Minimal -11% lift
Without
With
+-11.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
36 currently pending
Career history
1708
Total Applications
across all art units

Statute-Specific Performance

§101
2.1%
-37.9% vs TC avg
§103
19.1%
-20.9% vs TC avg
§102
19.4%
-20.6% vs TC avg
§112
43.7%
+3.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1672 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Election/Restrictions Applicant’s election with traverse of Group I in the reply filed on August 12, 2025 is acknowledged. Applicant’s traversal is on the ground that Groups I-III are inter-related (part of one and the same invention), and thus, would not be unduly burdensome. This is not found persuasive because Groups I-III are separate and patentably distinct because there is no patentable co-action among them. Hence, Applicant’s inventions are distinct and have acquired a separate status in the art due to their recognized divergent subject matter and different classification. Additionally, because each group has different subclasses, it would constitute a burden on the Examiner to search all subclasses. Further, different fields of search would be required in the non-patent literature. Still further, there is no special technical feature for the compounds or different fields of application of the compounds. Thus, a search of the three groups would impose an undue burden upon the Examiner. Therefore, the restriction for examination purposes as indicated is proper. The requirement is still deemed proper and is therefore made FINAL. Groups II-III are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a nonelected invention, there being no allowable generic or linking. Applicant reserved the right to file a divisional application to the non-elected subject matter. An action on the merits of Group I (claims 1-3, 6-12, and 27-30) is contained herein. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-3, 13, 19-22 and 27-28 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Davidowitz et al. (WO2018118791). This reference discloses the following STN/CAS compound(s) and composition: PNG media_image1.png 123 352 media_image1.png Greyscale RN 895709-06-5 ZCAPLUS CN 4(3H)-Quinazolinone, 3-(3-hydroxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) PNG media_image2.png 279 291 media_image2.png Greyscale PNG media_image3.png 246 340 media_image3.png Greyscale RN 2230843-15-7 ZCAPLUS CN 4(3H)-Quinazolinone, 3-(4-ethyl-3-hydroxyphenyl)-2-(3-pyridinyl)-, 2,2,2-trifluoroacetate (1:1) (CA INDEX NAME) PNG media_image3.png 246 340 media_image3.png Greyscale CN 4(3H)-Quinazolinone, 3-(4-chloro-3-hydroxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) PNG media_image4.png 246 329 media_image4.png Greyscale RN 2230843-17-9 ZCAPLUS CN 4(3H)-Quinazolinone, 3-(4-chloro-3-hydroxyphenyl)-2-(3-pyridinyl)-, hydrochloride (1:1) (CA INDEX NAME) PNG media_image5.png 280 329 media_image5.png Greyscale RN 2230843-43-1 ZCAPLUS CN 4(3H)-Quinazolinone, 3-(3-hydroxy-4-methylphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) PNG media_image6.png 246 321 media_image6.png Greyscale RN 2230843-44-2 ZCAPLUS CN 4(3H)-Quinazolinone, 3-(3-hydroxy-4-methylphenyl)-2-(3-pyridinyl)-, hydrochloride (1:1) (CA INDEX NAME) PNG media_image7.png 280 321 media_image7.png Greyscale RN 2230843-45-3 ZCAPLUS CN 4(3H)-Quinazolinone, 3-(3-hydroxyphenyl)-2-(3-pyridinyl)-, hydrochloride (1:1) (CA INDEX NAME) PNG media_image8.png 313 291 media_image8.png Greyscale The compounds and compositions read on the instant claim. Since this reference teaches the exact compound, Applicant’s claims are anticipated, and thus, rejected under 35 U.S.C. 102. Method claims 6-12, 14-18 and 29-30 are rejected because they are dependent on or related back to a rejected claim. Claims 1-3, 13, 19-22 and 27-28 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Wang et al. (Marine Drugs’2011). This reference discloses the following STN/CAS compound(s) and composition: RN 1339065-44-9 ZCAPLUS CN Benzoic acid, 3-hydroxy-2-[4-oxo-2-(3-pyridinyl)-3(4H)-quinazolinyl]-, methyl ester (CA INDEX NAME) PNG media_image9.png 275 325 media_image9.png Greyscale The compounds and compositions read on the instant claim. Since this reference teaches the exact compound, Applicant’s claims are anticipated, and thus, rejected under 35 U.S.C. 102. Method claims 6-12, 14-18 and 29-30 are rejected because they are dependent on or related back to a rejected claim. Claims 1, 4-9 and 11-16 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by the following STN/CAS compound(s) and composition: CN 3-(5-Bromo-2-hydroxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Br N3 O2 INCH InChI=1S/C19H12BrN3O2/c20-13-7-8-17(24)16(10-13)23-18(12-4-3-9-21-11-12)22-15-6-2-1-5-14(15)19(23)25/h1-11,24H INKY HBIBPBCFLSQVDS-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. PNG media_image10.png 238 309 media_image10.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 2 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895714-51-9 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(5-bromo-2-hydroxyphenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(5-Bromo-2-hydroxyphenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Br N3 O2 INCH InChI=1S/C19H12BrN3O2/c20-13-5-6-17(24)16(11-13)23-18(12-7-9-21-10-8-12)22-15-4-2-1-3-14(15)19(23)25/h1-11,24H INKY RVSSCBXVFKHAPC-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. PNG media_image11.png 235 309 media_image11.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 3 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895710-25-5 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(2-bromophenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(2-Bromophenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Br N3 O INCH InChI=1S/C19H12BrN3O/c20-15-6-2-4-8-17(15)23-18(13-9-11-21-12-10-13)22-16-7-3-1-5-14(16)19(23)24/h1-12H INKY TYTLVXNBENSVCQ-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. PNG media_image12.png 243 294 media_image12.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 4 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895709-06-5 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(3-hydroxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(3-Hydroxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H13 N3 O2 INCH InChI=1S/C19H13N3O2/c23-15-7-3-6-14(11-15)22-18(13-5-4-10-20-12-13)21-17-9-2-1-8-16(17)19(22)24/h1-12,23H INKY ADTAGVDONLIYTH-UHFFFAOYSA-N CI COM SR Chemical Library Supplier: Scientific Exchange, Inc. LC STN Files: CA, CAPLUS, CASBIOACTIVI, CASFORMULTNS, USPAT2, USPATFULL PNG media_image13.png 274 291 media_image13.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 1 REFERENCES IN FILE CA (1907 TO DATE) 1 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 5 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895708-75-5 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(2-methoxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(2-Methoxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C20 H15 N3 O2 INCH InChI=1S/C20H15N3O2/c1-25-18-11-5-4-10-17(18)23-19(14-7-6-12-21-13-14)22-16-9-3-2-8-15(16)20(23)24/h2-13H,1H3 INKY DTUHJMKQRYHEOW-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. PNG media_image14.png 243 291 media_image14.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 6 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895708-67-5 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(4-hydroxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Hydroxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H13 N3 O2 INCH InChI=1S/C19H13N3O2/c23-15-9-7-14(8-10-15)22-18(13-4-3-11-20-12-13)21-17-6-2-1-5-16(17)19(22)24/h1-12,23H INKY SLGVCZOSFNAKLN-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. LC STN Files: CA, CAPLUS PNG media_image15.png 246 339 media_image15.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 1 REFERENCES IN FILE CA (1907 TO DATE) 1 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 7 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895708-28-8 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(3-hydroxyphenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(3-Hydroxyphenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H13 N3 O2 INCH InChI=1S/C19H13N3O2/c23-15-5-3-4-14(12-15)22-18(13-8-10-20-11-9-13)21-17-7-2-1-6-16(17)19(22)24/h1-12,23H INKY DUIPYGRBWSLGQV-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. PNG media_image16.png 274 294 media_image16.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 8 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 895707-82-1 REGISTRY ED Entered STN: 25 Jul 2006 CN 4(3H)-Quinazolinone, 3-(4-hydroxyphenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Hydroxyphenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H13 N3 O2 INCH InChI=1S/C19H13N3O2/c23-15-7-5-14(6-8-15)22-18(13-9-11-20-12-10-13)21-17-4-2-1-3-16(17)19(22)24/h1-12,23H INKY ARRRXELEWSRCSF-UHFFFAOYSA-N SR Chemical Library Supplier: Scientific Exchange, Inc. PNG media_image17.png 249 339 media_image17.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 9 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 609822-68-6 REGISTRY ED Entered STN: 28 Oct 2003 CN 4(3H)-Quinazolinone, 3-phenyl-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-Phenyl-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H13 N3 O INCH InChI=1S/C19H13N3O/c23-19-16-10-4-5-11-17(16)21-18(14-7-6-12-20-13-14)22(19)15-8-2-1-3-9-15/h1-13H INKY HVJPRGIVMIGIBZ-UHFFFAOYSA-N SR Chemical Library Supplier: Ambinter LC STN Files: CA, CAPLUS, CASREACT, CHEMCATS, TOXCENTER PNG media_image18.png 243 291 media_image18.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 6 REFERENCES IN FILE CA (1907 TO DATE) 6 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 10 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 380653-15-6 REGISTRY ED Entered STN: 07 Jan 2002 CN 4(3H)-Quinazolinone, 3-(4-bromophenyl)-6-chloro-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Bromophenyl)-6-chloro-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H11 Br Cl N3 O INCH InChI=1S/C19H11BrClN3O/c20-13-3-6-15(7-4-13)24-18(12-2-1-9-22-11-12)23-17-8-5-14(21)10-16(17)19(24)25/h1-11H INKY ORXKAFNIXUJRIT-UHFFFAOYSA-N SR Chemical Library LC STN Files: CHEMCATS PNG media_image19.png 235 345 media_image19.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 11 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 380653-14-5 REGISTRY ED Entered STN: 07 Jan 2002 CN 4(3H)-Quinazolinone, 6-chloro-3-(2-methylphenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 6-Chloro-3-(2-methylphenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C20 H14 Cl N3 O INCH InChI=1S/C20H14ClN3O/c1-13-4-2-3-5-18(13)24-19(14-8-10-22-11-9-14)23-17-7-6-15(21)12-16(17)20(24)25/h2-12H,1H3 INKY MERNEXJBHGMTHY-UHFFFAOYSA-N SR Chemical Library PNG media_image20.png 243 335 media_image20.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 12 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 355371-39-0 REGISTRY ED Entered STN: 09 Sep 2001 CN 4(3H)-Quinazolinone, 3-[4-(diethylamino)phenyl]-2-(2-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-[4-(Diethylamino)phenyl]-2-(2-pyridinyl)-4(3H)-quinazolinone MF C23 H22 N4 O INCH InChI=1S/C23H22N4O/c1-3-26(4-2)17-12-14-18(15-13-17)27-22(21-11-7-8-16-24-21)25-20-10-6-5-9-19(20)23(27)28/h5-16H,3-4H2,1-2H3 INKY LQCGUVYKVQBEJV-UHFFFAOYSA-N SR Chemical Library Supplier: Ambinter PNG media_image21.png 246 378 media_image21.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 13 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 343937-87-1 REGISTRY ED Entered STN: 29 Jun 2001 CN Carbamothioic acid, diethyl-, S-[[6-(3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)-2-pyridinyl]methyl] ester (9CI) (CA INDEX NAME) MF C25 H24 N4 O2 S INCH InChI=1S/C25H24N4O2S/c1-3-28(4-2)25(31)32-17-18-11-10-16-22(26-18)23-27-21-15-9-8-14-20(21)24(30)29(23)19-12-6-5-7-13-19/h5-16H,3-4,17H2,1-2H3 INKY PMAZJLRPXUFGHK-UHFFFAOYSA-N SR Reaction Database LC STN Files: CA, CAPLUS, CASREACT, CHEMCATS PNG media_image22.png 306 434 media_image22.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 1 REFERENCES IN FILE CA (1907 TO DATE) 1 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 14 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 343841-98-5 REGISTRY ED Entered STN: 28 Jun 2001 CN 4(3H)-Quinazolinone, 3-(3,4-dichlorophenyl)-2-(2-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(3,4-Dichlorophenyl)-2-(2-pyridinyl)-4(3H)-quinazolinone MF C19 H11 Cl2 N3 O INCH InChI=1S/C19H11Cl2N3O/c20-14-9-8-12(11-15(14)21)24-18(17-7-3-4-10-22-17)23-16-6-2-1-5-13(16)19(24)25/h1-11H INKY QECJWXRHVGCWEW-UHFFFAOYSA-N SR Reaction Database LC STN Files: CHEMCATS PNG media_image23.png 246 329 media_image23.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 15 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 342604-06-2 REGISTRY ED Entered STN: 20 Jun 2001 CN 4(3H)-Quinazolinone, 2-(3-methyl-4-pyridinyl)-3-phenyl- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 2-(3-Methyl-4-pyridinyl)-3-phenyl-4(3H)-quinazolinone MF C20 H15 N3 O INCH InChI=1S/C20H15N3O/c1-14-13-21-12-11-16(14)19-22-18-10-6-5-9-17(18)20(24)23(19)15-7-3-2-4-8-15/h2-13H,1H3 INKY DXBOHFWDXXWRCK-UHFFFAOYSA-N SR Reaction Database LC STN Files: CHEMCATS PNG media_image24.png 243 294 media_image24.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 16 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 342390-46-9 REGISTRY ED Entered STN: 19 Jun 2001 CN 4(3H)-Quinazolinone, 6,8-dichloro-3-(4-ethoxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 6,8-Dichloro-3-(4-ethoxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C21 H15 Cl2 N3 O2 INCH InChI=1S/C21H15Cl2N3O2/c1-2-28-16-7-5-15(6-8-16)26-20(13-4-3-9-24-12-13)25-19-17(21(26)27)10-14(22)11-18(19)23/h3-12H,2H2,1H3 INKY AWKFHENBMVUXIA-UHFFFAOYSA-N SR Chemical Library Supplier: TimTec, Inc. LC STN Files: CHEMCATS PNG media_image25.png 281 381 media_image25.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 17 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 339992-73-3 REGISTRY ED Entered STN: 07 Jun 2001 CN 4(3H)-Quinazolinone, 3-(2-chloro-4-methylphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(2-Chloro-4-methylphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C20 H14 Cl N3 O INCH InChI=1S/C20H14ClN3O/c1-13-8-9-18(16(21)11-13)24-19(14-5-4-10-22-12-14)23-17-7-3-2-6-15(17)20(24)25/h2-12H,1H3 INKY FTEWVKFFMMFCEK-UHFFFAOYSA-N SR Reaction Database LC STN Files: CHEMCATS PNG media_image26.png 246 321 media_image26.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 18 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 329067-62-1 REGISTRY ED Entered STN: 27 Mar 2001 CN 4(3H)-Quinazolinone, 3-(4-bromophenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Bromophenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Br N3 O INCH InChI=1S/C19H12BrN3O/c20-14-5-7-15(8-6-14)23-18(13-9-11-21-12-10-13)22-17-4-2-1-3-16(17)19(23)24/h1-12H INKY BBKNTOCEBRHALK-UHFFFAOYSA-N SR Chemical Library Supplier: TimTec, Inc. LC STN Files: CHEMCATS PNG media_image27.png 249 330 media_image27.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 19 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 326920-24-5 REGISTRY ED Entered STN: 13 Mar 2001 CN 4(3H)-Quinazolinone, 3-(4-chlorophenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Chlorophenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Cl N3 O INCH InChI=1S/C19H12ClN3O/c20-14-7-9-15(10-8-14)23-18(13-4-3-11-21-12-13)22-17-6-2-1-5-16(17)19(23)24/h1-12H INKY VWFQBLKDSYGODR-UHFFFAOYSA-N SR Chemical Library Supplier: ChemStar, Ltd. LC STN Files: CA, CAPLUS, CHEMCATS, REAXYSFILESU*, TOXCENTER (*File contains numerically searchable property data) PNG media_image28.png 246 329 media_image28.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 1 REFERENCES IN FILE CA (1907 TO DATE) 1 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 20 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 326903-52-0 REGISTRY ED Entered STN: 13 Mar 2001 CN 4(3H)-Quinazolinone, 6,8-dichloro-3-(4-chlorophenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 6,8-Dichloro-3-(4-chlorophenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H10 Cl3 N3 O INCH InChI=1S/C19H10Cl3N3O/c20-12-3-5-14(6-4-12)25-18(11-2-1-7-23-10-11)24-17-15(19(25)26)8-13(21)9-16(17)22/h1-10H INKY FNOKURIWRJJIAM-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. LC STN Files: CHEMCATS PNG media_image29.png 235 344 media_image29.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 21 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 326903-51-9 REGISTRY ED Entered STN: 13 Mar 2001 CN 4(3H)-Quinazolinone, 3-(4-bromophenyl)-6,8-dichloro-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Bromophenyl)-6,8-dichloro-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H10 Br Cl2 N3 O INCH InChI=1S/C19H10BrCl2N3O/c20-12-1-3-14(4-2-12)25-18(11-5-7-23-8-6-11)24-17-15(19(25)26)9-13(21)10-16(17)22/h1-10H INKY SKEHJQZXFSUGKZ-UHFFFAOYSA-N SR Chemical Library Supplier: ChemDiv, Inc. LC STN Files: CHEMCATS PNG media_image30.png 235 345 media_image30.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 22 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 314052-11-4 REGISTRY ED Entered STN: 16 Jan 2001 CN 4(3H)-Quinazolinone, 3-(4-bromophenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Bromophenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Br N3 O INCH InChI=1S/C19H12BrN3O/c20-14-7-9-15(10-8-14)23-18(13-4-3-11-21-12-13)22-17-6-2-1-5-16(17)19(23)24/h1-12H INKY CVAPPRLNDAOYKA-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. LC STN Files: CA, CAPLUS, CASREACT, REAXYSFILESU* (*File contains numerically searchable property data) PNG media_image31.png 246 330 media_image31.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 1 REFERENCES IN FILE CA (1907 TO DATE) 1 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 23 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 313970-41-1 REGISTRY ED Entered STN: 15 Jan 2001 CN 4(3H)-Quinazolinone, 3-[4-(diethylamino)phenyl]-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-[4-(Diethylamino)phenyl]-2-(4-pyridinyl)-4(3H)-quinazolinone MF C23 H22 N4 O INCH InChI=1S/C23H22N4O/c1-3-26(4-2)18-9-11-19(12-10-18)27-22(17-13-15-24-16-14-17)25-21-8-6-5-7-20(21)23(27)28/h5-16H,3-4H2,1-2H3 INKY JDLOBTQDXJVTKL-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. PNG media_image32.png 249 378 media_image32.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 24 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 313969-62-9 REGISTRY ED Entered STN: 15 Jan 2001 CN 4(3H)-Quinazolinone, 6-chloro-3-(4-methoxyphenyl)-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 6-Chloro-3-(4-methoxyphenyl)-2-(4-pyridinyl)-4(3H)-quinazolinone MF C20 H14 Cl N3 O2 INCH InChI=1S/C20H14ClN3O2/c1-26-16-5-3-15(4-6-16)24-19(13-8-10-22-11-9-13)23-18-7-2-14(21)12-17(18)20(24)25/h2-12H,1H3 INKY NSFHTJCZAOGXAV-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. LC STN Files: CHEMCATS PNG media_image33.png 281 344 media_image33.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 25 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 313969-61-8 REGISTRY ED Entered STN: 15 Jan 2001 CN 4(3H)-Quinazolinone, 6-chloro-3-phenyl-2-(4-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 6-Chloro-3-phenyl-2-(4-pyridinyl)-4(3H)-quinazolinone MF C19 H12 Cl N3 O INCH InChI=1S/C19H12ClN3O/c20-14-6-7-17-16(12-14)19(24)23(15-4-2-1-3-5-15)18(22-17)13-8-10-21-11-9-13/h1-12H INKY NTFWYKHUPXKJMC-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. PNG media_image34.png 243 335 media_image34.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 26 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 313969-60-7 REGISTRY ED Entered STN: 15 Jan 2001 CN 4(3H)-Quinazolinone, 3-(4-ethoxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Ethoxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C21 H17 N3 O2 INCH InChI=1S/C21H17N3O2/c1-2-26-17-11-9-16(10-12-17)24-20(15-6-5-13-22-14-15)23-19-8-4-3-7-18(19)21(24)25/h3-14H,2H2,1H3 INKY ARWYRGGMBDERML-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. LC STN Files: CHEMCATS PNG media_image35.png 249 378 media_image35.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 27 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 313969-57-2 REGISTRY ED Entered STN: 15 Jan 2001 CN 4(3H)-Quinazolinone, 6,8-dichloro-3-(4-methoxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 6,8-Dichloro-3-(4-methoxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C20 H13 Cl2 N3 O2 INCH InChI=1S/C20H13Cl2N3O2/c1-27-15-6-4-14(5-7-15)25-19(12-3-2-8-23-11-12)24-18-16(20(25)26)9-13(21)10-17(18)22/h2-11H,1H3 INKY GVYHKGDAEICZOE-UHFFFAOYSA-N SR Chemical Library Supplier: Nanosyn Combinatorial Synthesis Inc. PNG media_image36.png 279 344 media_image36.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** L38 ANSWER 28 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 309952-00-9 REGISTRY ED Entered STN: 20 Dec 2000 CN 4(3H)-Quinazolinone, 3-(4-methoxyphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Methoxyphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C20 H15 N3 O2 INCH InChI=1S/C20H15N3O2/c1-25-16-10-8-15(9-11-16)23-19(14-5-4-12-21-13-14)22-18-7-3-2-6-17(18)20(23)24/h2-13H,1H3 INKY YZWLCEKFESZIAK-UHFFFAOYSA-N SR Chemical Library Supplier: ChemBridge Corporation LC STN Files: CA, CAPLUS, CASBIOACTIVI, CASREACT, CHEMCATS, REAXYSFILESU* (*File contains numerically searchable property data) PNG media_image37.png 249 340 media_image37.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 2 REFERENCES IN FILE CA (1907 TO DATE) 2 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 29 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 294195-68-9 REGISTRY ED Entered STN: 10 Oct 2000 CN 4(3H)-Quinazolinone, 3-(3-methylphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(3-Methylphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C20 H15 N3 O INCH InChI=1S/C20H15N3O/c1-14-6-4-8-16(12-14)23-19(15-7-5-11-21-13-15)22-18-10-3-2-9-17(18)20(23)24/h2-13H,1H3 INKY KZAKGGCXSSMWTF-UHFFFAOYSA-N SR Chemical Library Supplier: ChemDiv, Inc. LC STN Files: CA, CAPLUS, CASREACT, CHEMCATS, TOXCENTER PNG media_image38.png 268 291 media_image38.png Greyscale **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** 1 REFERENCES IN FILE CA (1907 TO DATE) 1 REFERENCES IN FILE CAPLUS (1907 TO DATE) L38 ANSWER 30 OF 30 REGISTRY COPYRIGHT 2025 ACS on STN RN 292639-73-7 REGISTRY ED Entered STN: 04 Oct 2000 CN 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-(3-pyridinyl)- (CA INDEX NAME) OTHER CA INDEX NAMES: CN 3-(4-Methylphenyl)-2-(3-pyridinyl)-4(3H)-quinazolinone MF C20 H15 N3 O INCH InChI=1S/C20H15N3O/c1-14-8-10-16(11-9-14)23-19(15-5-4-12-21-13-15)22-18-7-3-2-6-17(18)20(23)24/h2-13H,1H3 INKY OKOMERYGOHLZPI-UHFFFAOYSA-N SR Chemical Library Supplier: ChemDiv, Inc. LC STN Files: CA, CAPLUS, CASREACT, CHEMCATS, REAXYSFILESU* (*File contains numerically searchable property data) PNG media_image39.png 246 321 media_image39.png Greyscale The compounds and compositions read on the instant claim. Since this reference teaches the exact compound, Applicant’s claims are anticipated, and thus, rejected under 35 U.S.C. 102. Method claims 6-12, 14-18 and 29-30 are rejected because they are dependent on or related back to a rejected claim. Conclusion Claims 1-3, 6-12, and 27-30 are pending. Claims 1-3, 6-12, and 27-30 are rejected. No claims are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to PAUL V WARD whose telephone number is (571)272-2909. The examiner can normally be reached M-F 9am to 5pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, James Alstrum-Acevedo can be reached at 571-272-5548. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /PAUL V WARD/ Primary Examiner, Art Unit 1622
Read full office action

Prosecution Timeline

Oct 17, 2022
Application Filed
Apr 23, 2024
Non-Final Rejection — §102
Oct 21, 2024
Response Filed
Nov 21, 2024
Final Rejection — §102
Jan 27, 2025
Response after Non-Final Action
Feb 07, 2025
Non-Final Rejection — §102
Aug 12, 2025
Response Filed
Nov 05, 2025
Non-Final Rejection — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

4-5
Expected OA Rounds
83%
Grant Probability
72%
With Interview (-11.0%)
2y 7m
Median Time to Grant
High
PTA Risk
Based on 1672 resolved cases by this examiner. Grant probability derived from career allow rate.

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