Prosecution Insights
Last updated: October 27, 2026
Application No. 17/996,498

PROTEIN MARKERS FOR ASSESSING ALZHEIMER'S DISEASE

Non-Final OA §112
Filed
Oct 18, 2022
Priority
May 14, 2020 — provisional 63/024,940 +1 more
Examiner
CHERNYSHEV, OLGA N
Art Unit
1675
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
The Hong Kong University of Science and Technology
OA Round
3 (Non-Final)
54%
Grant Probability
Moderate
3-4
OA Rounds
0m
Est. Remaining
88%
With Interview

Examiner Intelligence

Grants 54% of resolved cases
54%
Career Allowance Rate
525 granted / 963 resolved
-5.5% vs TC avg
Strong +34% interview lift
Without
With
+34.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 11m
Avg Prosecution
64 currently pending
Career history
1014
Total Applications
across all art units

Statute-Specific Performance

§101
15.7%
-24.3% vs TC avg
§103
8.5%
-31.5% vs TC avg
§102
11.6%
-28.4% vs TC avg
§112
47.2%
+7.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 963 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Continued Examination Under 37 CFR 1.114 1. A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on September 10, 2026, has been entered. Response to Amendment 2. Claims 52-56, 59 and 60 have been amended as requested in the amendment filed on September 10, 2026. Following the amendment, claims 44-60 are pending in the instant application. 3. Claims 44-60 are under examination in the instant office action. 4. Any objection or rejection of record, which is not expressly repeated in this action has been overcome by Applicant’s response and withdrawn. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. 5. Claims 52-60, as amended, are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. 6. Claims 52, 54, 55, 56, 59 and 60, as currently presented, are indefinite for reciting limitations “using a prediction model” or “using an additional prediction model.” First, the claims provide for the use of a prediction model but, since the claims do not set forth any steps involved in the “using,” it is unclear what method/process applicant is intending to encompass. A claim is indefinite where it merely recites a use without any active, positive steps delimiting how this using is actually practiced. Second, the claims appear to recite at least two different prediction models, the first one as in independent claims 52 and 59, and the second one of the dependent claims 54 and 60, with potentially two more of claims 55 and 56. There appears no definitive boundaries set forth within the claims to delineate the models and to distinguish them. This renders the claims indefinite. Applicant is advised that if the claimed method of claim 52, for example, is limited to the active steps of calculating a prediction score by inputting a set of values into the formula recited therein, then deleting the limitation “using a prediction model” would obviate this ground of rejection. Alternatively, if the limitation describing prediction model(s) carries patentable weight and is critical to the inventive concept presented within the claims, then the rejection could be obviated by setting forth meaningful, active, physical and repeatable steps to support the “using.” 7. Claims 53, 57 and 58 are indefinite for being dependent from indefinite claim(s). Conclusion 8. Claims 44-51 are allowed. Claims 52-60 are rejected. Any inquiry concerning this communication or earlier communications from the examiner should be directed to OLGA N CHERNYSHEV whose telephone number is (571)272-0870. The examiner can normally be reached 9AM to 5:30PM, Monday to Friday. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey Stucker can be reached at (571)272-0911. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /OLGA N CHERNYSHEV/Primary Examiner, Art Unit 1675 September 23, 2026
Read full office action

Prosecution Timeline

Show 1 earlier event
Feb 11, 2026
Non-Final Rejection mailed — §112
May 01, 2026
Response Filed
Jun 10, 2026
Final Rejection mailed — §112
Aug 20, 2026
Applicant Interview (Telephonic)
Aug 20, 2026
Examiner Interview Summary
Sep 10, 2026
Request for Continued Examination
Sep 11, 2026
Response after Non-Final Action
Oct 05, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12716893
MATERIALS AND METHODS FOR DETECTING AND TREATING AUTOIMMUNE MOVEMENT DISORDERS
4y 10m to grant Granted Aug 25, 2026
Patent 12710431
DIAGNOSTIC FOR CHILDHOOD RISK OF AUTISM SPECTRUM DISORDER
4y 10m to grant Granted Aug 18, 2026
Patent 12710433
Diagnosing a Disease Associated with Synaptic Degeneration using an Elisa for Determining a Beta-Synuclein Concentration in CSF
3y 12m to grant Granted Aug 18, 2026
Patent 12708657
PHARMACEUTICAL COMPOSITION FOR TREATING DEGENERATIVE BRAIN DISEASE, INCLUDING GLYCINE TRANSPORTER AS ACTIVE INGREDIENT
3y 10m to grant Granted Aug 18, 2026
Patent 12698344
ANTI-IDE ANTIBODIES AND USES OF SAME
4y 0m to grant Granted Aug 04, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
54%
Grant Probability
88%
With Interview (+34.0%)
2y 11m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 963 resolved cases by this examiner. Grant probability derived from career allowance rate.

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