Prosecution Insights
Last updated: April 19, 2026
Application No. 17/998,388

FORMULATIONS OF ANTI-IL-33 ANTIBODIES

Final Rejection §DP§Other
Filed
Nov 10, 2022
Examiner
BELYAVSKYI, MICHAIL A
Art Unit
1644
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
MedImmune, LLC
OA Round
2 (Final)
64%
Grant Probability
Moderate
3-4
OA Rounds
3y 1m
To Grant
91%
With Interview

Examiner Intelligence

Grants 64% of resolved cases
64%
Career Allow Rate
697 granted / 1091 resolved
+3.9% vs TC avg
Strong +27% interview lift
Without
With
+27.2%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
77 currently pending
Career history
1168
Total Applications
across all art units

Statute-Specific Performance

§101
2.3%
-37.7% vs TC avg
§103
29.0%
-11.0% vs TC avg
§102
9.7%
-30.3% vs TC avg
§112
10.9%
-29.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1091 resolved cases

Office Action

§DP §Other
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . RESPONSE TO APPLICANT’S AMENDMENT 1. Applicants amendment filed on 01/16/26 is acknowledged. 2. Claims 1,3-5,10-13,15,19-22, 24-30,34,35,36,38, and 44 are pending. 3. Claims 36,38 stand withdrawn from further consideration by the Examiner, 37 C.F.R. § 1.142(b) as being drawn to nonelected inventions. Claims 1,3-5,10-13,15,19-22, 24-30,34,35,36,38,and 44 read on a composition comprising anti-IL-33 antibody, 190to 25 mM of arginine and are under consideration in the instant application. 4. In view of Applicant’s amendment ( filed on 01/16/26) and statement that the claimed composition comprising recited amount of antibody, i.e. about 150mg/ml and claimed formulation that achieves markedly reduced viscosity, i.e. decoupling concentration from viscosity for a self-associating antibody was completely surprising and counterintuitive the previous rejections of claims under first paragraph of 35 U.S.C. 112(a,b) and under 35 U.S.C. 103 is hereby withdrawn. ( see Applicant’s response filed on 01/16/26 page 8) 5. Claims 1,3-5,10-13,15,19-22, 24-30,34,35,36,38,and 44 are provisionally rejected on the grounds of nonstatutory double patenting of the claims of copending Applications No: 20250136676, 20230174637; US 20230110203 for the same reasons set forth in the previous Office Action mailed on 10/21/25. Although the conflicting claims are not identical, they are not patentably distinct from each other because the claims of the instant Application are drawn to composition that is used in methods of treating recited in claims of copending Applications No: 20250136676, 20230174637; US 20230110203 and wherein was disclosed in the specification of said Patents. This rejection is necessitated by the decision of the Court of Appeals for the Federal Circuit in Pfizer Inc. v Teva pharmaceuticals USA Inc., 86 USPQ2d 1001, at page 1008 (March 2008), which indicates that there is no patentable distinction between claims to a product and a method of using that product disclosed in the specification of the application and that the preclusion of such a double patenting rejection under 35 USC 121 does not apply where the present application is other than a divisional application of the patent application containing such patentably indistinct claims. This is a provisional obviousness-type double patenting rejection because the conflicting claims have not in fact been patented. It is noted that Applicant requested to hold that provisional double patenting rejection in abeyance until allowable subject matter is identified. 6. No claim is allowed. 7. THIS ACTION IS MADE FINAL. See MPEP § 609(B)(2)(i). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. 8. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Michail Belyavskyi whose telephone number is 571/272-0840. The examiner can normally be reached Monday through Friday from 9:00 AM to 5:30 PM. A message may be left on the examiner's voice mail service. If attempts to reach the examiner by telephone are unsuccessful, the examiner's supervisor, Daniel Kolker can be reached on 571/ 272-3181 The fax number for the organization where this application or proceeding is assigned is 571/273-8300 Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free).
Read full office action

Prosecution Timeline

Nov 10, 2022
Application Filed
Oct 16, 2025
Non-Final Rejection — §DP, §Other
Jan 16, 2026
Response Filed
Mar 12, 2026
Final Rejection — §DP, §Other (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12599675
NOVEL CONJUGATE OF IMMUNE-STIMULATING IL-2 ANALOG AND PREPARATION METHOD THEREOF
2y 5m to grant Granted Apr 14, 2026
Patent 12589113
PREPARATION OF A THERAPEUTIC COMPOSITION FOR TREATING AUTOIMMUNE DISEASES
2y 5m to grant Granted Mar 31, 2026
Patent 12584125
METHODS AND USE OF CHIMERIC PROTEINS
2y 5m to grant Granted Mar 24, 2026
Patent 12577581
USE OF PRE T ALPHA OR FUNCTIONAL VARIANT THEREOF FOR EXPANDING TCR ALPHA DEFICIENT T CELLS
2y 5m to grant Granted Mar 17, 2026
Patent 12570959
PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY
2y 5m to grant Granted Mar 10, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.
Powered by AI — typically takes 5-10 seconds

Prosecution Projections

3-4
Expected OA Rounds
64%
Grant Probability
91%
With Interview (+27.2%)
3y 1m
Median Time to Grant
Moderate
PTA Risk
Based on 1091 resolved cases by this examiner. Grant probability derived from career allow rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month