Prosecution Insights
Last updated: April 19, 2026
Application No. 17/999,744

METHOD FOR RECOVERING MALONATE FROM A FERMENTATION BROTH

Non-Final OA §112
Filed
Nov 23, 2022
Examiner
DOLETSKI, BLAINE G
Art Unit
1692
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Cargill Incorporated
OA Round
1 (Non-Final)
76%
Grant Probability
Favorable
1-2
OA Rounds
2y 2m
To Grant
83%
With Interview

Examiner Intelligence

Grants 76% — above average
76%
Career Allow Rate
415 granted / 548 resolved
+15.7% vs TC avg
Moderate +7% lift
Without
With
+7.2%
Interview Lift
resolved cases with interview
Typical timeline
2y 2m
Avg Prosecution
26 currently pending
Career history
574
Total Applications
across all art units

Statute-Specific Performance

§101
0.5%
-39.5% vs TC avg
§103
41.1%
+1.1% vs TC avg
§102
15.7%
-24.3% vs TC avg
§112
26.3%
-13.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 548 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Claim Status Claims 1-18, 20, 22-23 and 43 are pending. Claims 1-18, 20, 22-23 and 43 are under examination. Claims 1-18, 20, 22-23 and 43 are rejected. No claims are allowed. Filing Receipt PNG media_image1.png 96 1000 media_image1.png Greyscale PNG media_image2.png 100 998 media_image2.png Greyscale PNG media_image3.png 112 1000 media_image3.png Greyscale PNG media_image4.png 98 996 media_image4.png Greyscale Specification The disclosure is objected to because of the following informalities: The specification fails to have support for the claim 10 limitation of “an aqueous solution bulk temperature” nor the definition thereof. The specification does contemplate “an aqueous bulk temperature” but does not define the phrase or explain the significance of the “aqueous solution bulk temperature” as opposed to the “aqueous bulk temperature”. See paragraph 26 of the specification. Appropriate correction is required. Claim Objections Claim 43 is objected to because of the following informalities: The phrase “of any” in line 1 is not needed. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-18, 20, 22-23 and 43 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 1, textual line 7 recites the phrase “fermentation broth comprising malonate”. The malonate may be referring to the “a malonate” comprising the compound of formula I in line 1 of claim 1 or another unknown malonate, for example diethyl malonate or disodium malonate or calcium malonate. Note: step b) of claim 1 properly refers to the “a malonate” in line 1 of claim 1 by utilizing the definite article “the”. See claim 1, step b), wherein, “b) recovering the malonate from the first aqueous….”. Claim 2 is indefinite due to the temperature not being assigned to an entity of claim 1 and or 2. For example, the temperature can be referring to the temperature of “the first aqueous concentrate” or some other entity yet disclosed. Note: claim 3 refers to a pH of the first aqueous concentrate. Herein the entity having the claimed pH is known. Claim 7 is indefinite due to the conflicting concentrations of the malonate. Claim 7 allows for the concentration to be less than the required 400 g/kg in step a) of claim 1. Additionally, the limitation of 40 g/kg to about 400 g/kg lacks antecedent basis. For example, upon performing step c) and proceeding directly to step b), the concentration of the broth will be 40 g/kg to about 400 g/kg. This range directly contradicts the range in claim 1. Note: The g/kg range in claim 8 has antecedent basis to the g/kg range of claim 1. Claim 10 is directed to the phrase “an aqueous solution bulk temperature” The specification does contemplate “an aqueous bulk temperature” but does not define the phrase nor explain the significance of the “aqueous solution bulk temperature” as opposed to the “aqueous bulk temperature”. Claim 10 can just as easily be written “removing water from the fermentation broth at a temperature of less than 100C” without changing the scope of the claim. The phrase “an aqueous solution bulk temperature” adds ambiguity and possibly adds limitations to the claim that are not understood and not positively recited. Claim 12 does not clearly specify which entity of the claims has the temperature of “at least 30C”. See the 112(b) rejection of claim 2. Claim 13 does not clearly specify which entity of the claims has the temperature of 0 to 30C. Note: claim 14 specifies the fermentation broth has the claimed pH. Herein the reader immediately understands to what entity has the claimed pH. Claim 16 is referring to a malonate. Without the definite article preceding the word malonate, the malonate can be any malonate. For example, diethyl malonate. See 112(b) rejection of claim 1. Note: claim 15 refers to malonate with the definite article “the”. Claim 17 has the same indefiniteness as claim 16. The definite article is needed to ensure the malonate is understood to be referring to the malonate that comprises the compound of formula I in claim 1. Without doing so the malonate can be a disodium malonate or a mono or diethyl malonate. Claim 43 does not utilize the definite article “the” prior to the malonate in line 1. In general, when referring back to the “malonate” on line 1 of claim 1, the malonate in the dependent claims may be referred to as “the malonate comprising the compound of formula I”. The optional compound of formula II would necessarily be included due to the comprising language. The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claim 7 is rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. The limitation of 40 g/kg to about 400 g/kg broadens the range of “at least about 400 g/kg” in claim 1 or at least does not further the range of claim 1. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Allowable Subject Matter The following is a statement of reasons for the indication of allowable subject matter: Upon overcoming the rejections of record, the current claims would be allowable. The closest prior art to the invention is Fruchey et al. (USPGPub 2013/0140169, Published 06-2013. Cited as D1 in the international search for PCT/US2021/034881). Fruchey et al. strongly suggests the preparation of the single potassium salt of malonate in a fermentation broth containing n-propyl malonate. See immediately below. PNG media_image5.png 140 618 media_image5.png Greyscale PNG media_image6.png 134 618 media_image6.png Greyscale However, Fruchey et al. does not disclose or fairly suggest recovering the malonate salt from the fermentation broth nor removing water to the claimed concentration of the malonate. To the contrary, Fruchey et al. teach treating the salt to prepare the appropriate fermentation broth. Preparing a fermentation broth does not suggest removing a substance from a fermentation broth nor the water from the fermentation broth. It would not have been obvious to have modified the prior art to arrive at the invention. There being no motivation to do so. In a separate location of Fruchey et al. there is a strong suggestion to make monopotassium salts of dicarboxylic acids in a liquid. See immediately below. PNG media_image7.png 142 624 media_image7.png Greyscale PNG media_image8.png 110 616 media_image8.png Greyscale PNG media_image9.png 166 620 media_image9.png Greyscale As argued above, Fruchey et al. strongly suggests the single potassium salt of malonate. However, Fruchey et al. fails to disclose or fairly suggest recovering the monopotassium salt of the dicarboxylic acid nor removing water to achieve the claimed concentration of the malonate. It would not have been obvious to have modified the prior art to arrive at the invention. There being no motivation to do so. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to BLAINE G DOLETSKI whose telephone number is (571)272-2766. The examiner can normally be reached M-F 7-4 EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Scarlett Goon can be reached at (571)270-5241. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /B.G.D/ Examiner, Art Unit 1692 /Andrew D Kosar/Supervisory Patent Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Nov 23, 2022
Application Filed
Nov 18, 2025
Non-Final Rejection — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12600836
PROCESS FOR RECYCLING POLYETHYLENE TEREPHTHALATE USING A GRADIENT IN IMPURITY CONCENTRATION
2y 5m to grant Granted Apr 14, 2026
Patent 12590005
PROCESS AND REACTOR FOR PRODUCING PHOSGENE
2y 5m to grant Granted Mar 31, 2026
Patent 12545635
SYSTEM AND METHOD FOR PRODUCING DIESTER-BASED COMPOSITION
2y 5m to grant Granted Feb 10, 2026
Patent 12509412
POLYMERIZABLE RAW MATERIAL COMPRISING RECYCLED BIS(2-HYDROXYETHYL) TEREPHTHALATE AND METHOD FOR PREPARING THE SAME
2y 5m to grant Granted Dec 30, 2025
Patent 12503431
METHOD FOR REDUCING THE CONCENTRATION OF SO3 IN A REACTION MIXTURE COMPRISING METHANE SULFONIC ACID AND SO3
2y 5m to grant Granted Dec 23, 2025
Study what changed to get past this examiner. Based on 5 most recent grants.

AI Strategy Recommendation

Get an AI-powered prosecution strategy using examiner precedents, rejection analysis, and claim mapping.
Powered by AI — typically takes 5-10 seconds

Prosecution Projections

1-2
Expected OA Rounds
76%
Grant Probability
83%
With Interview (+7.2%)
2y 2m
Median Time to Grant
Low
PTA Risk
Based on 548 resolved cases by this examiner. Grant probability derived from career allow rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month