Prosecution Insights
Last updated: April 19, 2026
Application No. 18/011,590

TYK-2 INHIBITOR

Non-Final OA §112§DP
Filed
Dec 20, 2022
Examiner
COLEMAN, BRENDA LIBBY
Art Unit
1624
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
BEIGENE, LTD.
OA Round
3 (Non-Final)
75%
Grant Probability
Favorable
3-4
OA Rounds
2y 7m
To Grant
90%
With Interview

Examiner Intelligence

Grants 75% — above average
75%
Career Allow Rate
1201 granted / 1604 resolved
+14.9% vs TC avg
Strong +15% interview lift
Without
With
+15.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 7m
Avg Prosecution
46 currently pending
Career history
1650
Total Applications
across all art units

Statute-Specific Performance

§101
1.5%
-38.5% vs TC avg
§103
5.8%
-34.2% vs TC avg
§102
16.9%
-23.1% vs TC avg
§112
52.3%
+12.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1604 resolved cases

Office Action

§112 §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Claims 1 and 3-20 are pending in the application. This action is in response to applicants' amendment dated January 16, 2026. Claims 3, 6-11 and 16 have been amended. Response to Amendment Applicant's arguments filed January 16, 2026 have been fully considered with the following effect: With regards to the provisional nonstatutory double patenting rejection as being 3. unpatentable over claims 1 and 96-98 of copending Application No. 18/748,855 of the last office action, the applicants stated that the provisional nonstatutory rejection will be the only remaining rejection in this application and thus should be withdraw. However, provisional nonstatutory double patenting rejection is not the only rejection remaining in view of the new grounds of rejection listed below and is herein maintained. Claims 1, 3-11 and 14-20 are provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1 and 96-98 of copending Application No. 18/748,855, for reasons of record and stated above. The applicant's amendments and arguments are sufficient to overcome the 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph rejections, labeled paragraph 3a), b), c), d), e), f), g), h), i), j), k), l), m), n), o), p) and q) in the last office action, which are hereby withdrawn. In view of the amendment dated January 16, 2026, the following new grounds of rejection apply: Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION. —The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 6-11 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor, or for pre-AIA the applicant regards as the invention. The following reasons apply: Claims 6, 7 and claims dependent thereon are vague and indefinite in that it is not known what is meant by the definition of Re with respect paragraph ii) which ends with a semi-colon and a comma. Claim 6 and claims dependent thereon are vague and indefinite in that it is not known what is meant by the hyphen which appears definition of R3 within the definition of the substituents on the C1-6alkyl of the heteroaryl definition which is defined as “selected from halogen, hydroxy, -NH2, - or C1-6alkoxy”. Claim 10 is vague and indefinite in that it is not known what is meant by “propyl (iso-propyl)” in the definition of Re which are two different substituents. Claim Objections Claims 12 and 13 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Any inquiry concerning this communication or earlier communications from the examiner should be directed to BRENDA L COLEMAN whose telephone number is (571)272-0665. The examiner can normally be reached Mon-Fri 10-6 (flex). Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey H. Murray can be reached at 571-272-9023. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRENDA L COLEMAN/Primary Examiner, Art Unit 1624
Read full office action

Prosecution Timeline

Dec 20, 2022
Application Filed
Jul 02, 2025
Non-Final Rejection — §112, §DP
Sep 26, 2025
Response Filed
Oct 14, 2025
Final Rejection — §112, §DP
Jan 16, 2026
Request for Continued Examination
Jan 23, 2026
Response after Non-Final Action
Feb 24, 2026
Non-Final Rejection — §112, §DP (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12595228
PROCESS FOR SYNTHESIZING TRIARYLMETHANE SULFONE COMPOUNDS
2y 5m to grant Granted Apr 07, 2026
Patent 12595259
AMINOPYRIDINE COMPOUND
2y 5m to grant Granted Apr 07, 2026
Patent 12590081
FUSED IMIDAZOLE DERIVATIVES, PREPARATION METHOD AND MEDICINAL USE THEREOF
2y 5m to grant Granted Mar 31, 2026
Patent 12575569
METHODS OF CONTROLLING OR PREVENTING INFESTATION OF RICE PLANTS BY THE PHYTOPATHOGENIC MICROORGANISM GIBBERELLA FUJIKUROI
2y 5m to grant Granted Mar 17, 2026
Patent 12577262
FUNCTIONALIZED GOLD CARBENE NAPTHAQUINONE COMPLEXES FOR USE IN THE TREATMENT OF CANCER
2y 5m to grant Granted Mar 17, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
75%
Grant Probability
90%
With Interview (+15.4%)
2y 7m
Median Time to Grant
High
PTA Risk
Based on 1604 resolved cases by this examiner. Grant probability derived from career allow rate.

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