Office Action Predictor
Application No. 18/012,237

Bisphosphonate-Modified Liposomes Containing Nanoparticles

Non-Final OA §102
Filed
Dec 22, 2022
Examiner
CABRAL, ROBERT S
Art Unit
1614
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Pharma Development Holding GMBH
OA Round
1 (Non-Final)
62%
Grant Probability
Moderate
1-2
OA Rounds
3y 4m
To Grant
83%
With Interview

Examiner Intelligence

62%
Career Allow Rate
528 granted / 848 resolved
Without
With
+20.3%
Interview Lift
avg trend
3y 4m
Avg Prosecution
28 pending
876
Total Applications
career history

Statute-Specific Performance

§101
2.2%
-37.8% vs TC avg
§103
39.8%
-0.2% vs TC avg
§102
23.0%
-17.0% vs TC avg
§112
21.3%
-18.7% vs TC avg
Black line = Tech Center average estimate • Based on career data

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Applicant’s preliminary amendment filed 12/22/2022, is acknowledged. Claims 15-28 are new. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 15-28 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Greb et al. (U.S. Patent No. 7,455,856). Regarding claim 15, Greb et al. provides a bisphosphonic acid of the general formula (I): PNG media_image1.png 200 400 media_image1.png Greyscale (claim 16). Abstract. These compounds “are suitable in particular for preparing liposomal preparations and preparing medicaments that can be used for the treatment of animals and humans.” Col. 4., lines 18-21. Further, the compounds “are used in a composition in the presence of suitable conjugates. The conjugates can be selected from liposomes, nanoparticles, nanospheres, nanocapsules, micelles, or polymer systems.” Col. 5, lines 43-46. Regarding claim 17, “[p]referably, the compounds of the general formula (I) or their derivatives in combination with a mixture of phospholipids, including a uronic acid derivative as an enveloping material.” Col. 5, lines 46-49. Regarding claims 18-20 and 23, the composition may also include pharmaceutically active substances, diagnostic agents and magnetic particles. See col. 6, lines 3-6. Regarding claim 21, the compounds may be bounded to an active agent or diagnostic agent. See col. 5, lines 14-15. Regarding claim 22, pharmaceutically active substances include anti-inflammatory agents. See col. 4, line 48. Regarding claims 24-28, Greb et al. discloses a process involving a solution. See col. 7, line 38. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to ROBERT S CABRAL whose telephone number is (571)270-3769. The examiner can normally be reached M-F 8 am - 5 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Ali Soroush can be reached at 571-272-9925. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ROBERT S CABRAL/Primary Examiner, Art Unit 1614
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Prosecution Timeline

Dec 22, 2022
Application Filed
Sep 29, 2025
Non-Final Rejection — §102
Apr 04, 2026
Response after Non-Final Action

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Prosecution Projections

1-2
Expected OA Rounds
62%
Grant Probability
83%
With Interview (+20.3%)
3y 4m
Median Time to Grant
Low
PTA Risk
Based on 848 resolved cases by this examiner