Prosecution Insights
Last updated: August 15, 2026
Application No. 18/015,309

PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Final Rejection §102
Filed
Jan 09, 2023
Priority
Jul 10, 2020 — CN 202010658037.9 +2 more
Examiner
YOO, SUN JAE
Art Unit
1621
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Xizang Haisco Pharmaceutical Co., Ltd.
OA Round
2 (Final)
71%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
71%
With Interview

Examiner Intelligence

Grants 71% — above average
71%
Career Allowance Rate
876 granted / 1234 resolved
+11.0% vs TC avg
Minimal +0% lift
Without
With
+0.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
110 currently pending
Career history
1296
Total Applications
across all art units

Statute-Specific Performance

§101
1.1%
-38.9% vs TC avg
§103
17.0%
-23.0% vs TC avg
§102
27.6%
-12.4% vs TC avg
§112
33.8%
-6.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1234 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status 1. The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Amendment 2. The amendments to the claims filed on January 28, 2026 have been fully considered. The amendments are sufficient to overcome the outstanding grounds of rejection which are withdrawn. 3. Pursuant MPEP 803.02 the search and examination was extended. Prior art was found that anticipates the amended Markush claims with respect to a nonelected species. Therefore, the amended Markush claims were rejected and claims to nonelected species held withdrawn from further consideration. The claims were further searched to the extent of claims 10, 11, 16, 20 and 21 and further to the nonelected species shown below. Claim Objections 4. Claims 10, 11, 16, 20 and 21 objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. 5. Claim(s) 1, 5, 8, 14 and 17 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by RN 2265925-51-5 ( PNG media_image1.png 182 230 media_image1.png Greyscale ). The reference has a publication date of February 5, 2019 which antedates the present claims having an effective filing date of July 9, 2021 and priority claim to foreign applications dated July 10, 2020 and October 20, 2020. The compound corresponds to the present claims in the following manner: Cy1= option 1; Cy2a=g with RD=heteroaryl; Cy3=option 1. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to SUN JAE YOO whose telephone number is (571)272-9074. The examiner can normally be reached Mon-Fri 8-5. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /SUN JAE YOO/Primary Examiner, Art Unit 1621
Read full office action

Prosecution Timeline

Jan 09, 2023
Application Filed
Nov 07, 2025
Non-Final Rejection mailed — §102
Jan 28, 2026
Response Filed
Apr 06, 2026
Final Rejection mailed — §102 (current)

Precedent Cases

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Patent 12674026
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Patent 12661353
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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
71%
Grant Probability
71%
With Interview (+0.3%)
2y 8m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1234 resolved cases by this examiner. Grant probability derived from career allowance rate.

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