Prosecution Insights
Last updated: April 19, 2026
Application No. 18/018,209

TEST REAGENT WITH AMELIORATED SIGNAL REDUCTION

Non-Final OA §102§112
Filed
Jan 26, 2023
Examiner
GABEL, GAILENE
Art Unit
1678
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Denka Company Limited
OA Round
1 (Non-Final)
75%
Grant Probability
Favorable
1-2
OA Rounds
3y 4m
To Grant
99%
With Interview

Examiner Intelligence

Grants 75% — above average
75%
Career Allow Rate
688 granted / 913 resolved
+15.4% vs TC avg
Strong +46% interview lift
Without
With
+45.6%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
22 currently pending
Career history
935
Total Applications
across all art units

Statute-Specific Performance

§101
4.3%
-35.7% vs TC avg
§103
26.9%
-13.1% vs TC avg
§102
19.9%
-20.1% vs TC avg
§112
34.2%
-5.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 913 resolved cases

Office Action

§102 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Election/Restrictions 1. Applicant's election of Group II, claims 9-15, without traverse, filed December 30, 2025 is acknowledged and has been entered. Applicant also elected species (1) viral antigen as target substance, (2) nasal aspirate as specimen, (3) EDTA 10-150 mM as chelating agent, and (4) antigen-antibody reaction. Claims 9-15 read on the elected species in (1) to (4). Claims 1-8 are withdrawn from further consideration by the examiner, 37 CFR 1.142(b), as being claims drawn to a non-elected invention. Accordingly, claims 1-15 are pending. Claims 9-15 are under examination. Priority 2. Receipt is acknowledged of certified copies of foreign priority papers required by 37 CFR 1.55, which papers have been placed of record in the file. 3. Acknowledgment is made of applicant’s claim for foreign priority under 35 U.S.C. 119 (a)-(d) or (f), 365(a) or (b) or 386(a). Based on the filing receipt, the effective filing date of this National Stage application, which is a 371 of PCT/JP2021/027337 filed 07/21/2021, is July 27, 2020 which is the filing date of Foreign Application JAPAN 2020-126241 filed 07/27/2020 from which the benefit of foreign priority is claimed. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. 4. Claims 9-15 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 9 is vague and indefinite in reciting “A method for detecting, by utilizing an antigen-antibody reaction or reaction between substances… wherein detection is performed with signal reduction suppressed by previously contacting the specimen with a chelating agent” because it recites the use of “antigen-antibody reaction or a reaction between substances” and “signal reduction suppressed by previously contacting the specimen with a chelating agent” but, since the claim does not set forth any steps involved in the method/process, it is unclear what method/process Applicant is intending to encompass. A claim is indefinite where it merely recites a use without any active, positive steps delimiting how this use is actually practiced. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. 5. Claims 9-15 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Hideki et al. (JP 2016 099131). Hideki et al. disclose an immunochromatography method for detecting a target substance which is specifically a virus antigen (microorganism) present in a specimen using an immunochromatographic device to detect antigen-antibody reaction signal; wherein signal reduction is detected as suppressed by a chelating agent that is contacted with the specimen. The method comprises combining the specimen with a specimen extracting solution which comprises an enzyme and a surfactant, and also contains a chelating agent; and adding or dispensing the resultant mixture to the immunochromatographic device. The specimen extracting solution containing the chelating agent may be impregnated onto a portion of the immunochromatographic device. The specimen extracting solution contains the chelating agent at a concentration of 1 mM to 100 mM (encompassed within 8 mM to 300 mM in claim 13 and within 25 mM to 300 mM in claim 14); wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA). See entire document; especially paragraphs [0017, 0018, 0021-0024] and Example 2. Accordingly, Hideki et al. appears to read on Applicant’s claimed invention. 6. No claims are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to GAILENE R. GABEL whose telephone number is (571)272-0820. The examiner can normally be reached Monday, Tuesday, and Thursday 5:30 AM to 4:00 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Gregory S. Emch can be reached at (571) 272-8149. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /GAILENE GABEL/Primary Examiner, Art Unit 1678 February 6, 2026
Read full office action

Prosecution Timeline

Jan 26, 2023
Application Filed
Feb 07, 2026
Non-Final Rejection — §102, §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
75%
Grant Probability
99%
With Interview (+45.6%)
3y 4m
Median Time to Grant
Low
PTA Risk
Based on 913 resolved cases by this examiner. Grant probability derived from career allow rate.

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