Prosecution Insights
Last updated: April 19, 2026
Application No. 18/018,832

NANOHYBRID STRUCTURES CONTAINING ANTIMICROBIAL NANOPARTICLES

Non-Final OA §103
Filed
Jan 30, 2023
Examiner
MAEWALL, SNIGDHA
Art Unit
1612
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
P&S Global Holdings LLC
OA Round
1 (Non-Final)
58%
Grant Probability
Moderate
1-2
OA Rounds
3y 4m
To Grant
69%
With Interview

Examiner Intelligence

Grants 58% of resolved cases
58%
Career Allow Rate
611 granted / 1044 resolved
-1.5% vs TC avg
Moderate +10% lift
Without
With
+10.2%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
59 currently pending
Career history
1103
Total Applications
across all art units

Statute-Specific Performance

§101
0.6%
-39.4% vs TC avg
§103
51.6%
+11.6% vs TC avg
§102
8.7%
-31.3% vs TC avg
§112
17.5%
-22.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1044 resolved cases

Office Action

§103
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Detailed Action Restriction/Election Applicant’s election without traverse of Group I, claims 7-12 in the reply filed on 07/18/25 is acknowledged. Applicant’s election of Calcium carbonate, Silver nitrate and 3-methacryloxypropyl trimethoxysilane (containing a methacryloxy group) is also acknowledged. Claims 1-6 and 13-19 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on 07/18/25. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claims 7-12 are rejected under 35 U.S.C. 103 as being unpatentable over Yu et al. ("Synthesis of Ag-SiO2-APTES nanocomposites by blending poly(vinylidene fluoride) membrane with potential applications on dye wastewater treatment", presented in IDS). Yu discloses a “multifunctional membrane with antibacterial property and antifouling property, we synthesized Ag-SiO2 nanocomposites successfully and used 3-aminopropyltriethoxysilane (APTES) to functionalize the surface of Ag-SiO2 to obtain superior dispersity in casting solution"), see (page 2, col. 2, paragraph 2), thus Yu discloses an antimicrobial nanohybrid structure as claimed. Yu further teaches saturating a first carrier material with a plethora of metallic salt precursors thereby creating a mixture "as Fig. 1(a) shows, SiO2 (0.6 g) was dispersed in pure water (30 ml) and stirred for 30 min to form a homogenous suspension, see (pg. 3 col. 2 para 1), then " silver ammonia solution (0.849 g silver nitrate as silver ion source was dissolved in 10 mI distilled water, gradually ammonia was added in the mixed solution until the white precipitate just disappeared 0.005 M, 30 ml) was added to the mixture and stirred for 1h at room temperature ... 100 ml 2 wt.% PVP ethanol solution was added to the mixture and heated at 70 DEG C for 7 h. The Ag-SiO2 was separated by centrifugation"; also see pg. 3 Fig. 1a) and see wherein it is taught that (pg 3 col 2 para 1: “3-aminopropyltriethoxysilane (20 g) was added dropwise into the mixture under continuous stirring at 110 DEG C for 6 h. The Ag-SiO2-APTES was separated by centrifugation"); and on page 5 col 1 para 2, see "for the Ag-SiO02-APTES nanocomposites, four additional diffraction peaks appear ... corresponding to the ... face- centered cubic (fcc) Ag crystal ... This result affirms that Ag NPs were formed onto the surface of SiO2 nanoparticles”) with inherent antimicrobial properties (pg. 2 col. 2 para 1: “silver with a broad spectrum of antibacterial activities has been demonstrated to be useful and effective in bactericidal applications"). Yu discloses the antimicrobial nanohybrid structure and . Yu further discloses wherein the metallic salt precursor is a material selected from the group consisting of silver (pg. 3 col. 2 paragraph 1 and Fig. 1a), copper, copper oxide, zinc oxide, nickel, selenium, titanium, and titanium dioxide. Yu discloses wherein the coupling agent is an organosilane with an organofunctional group (pg. 3 col. 2 paragraph 1; 3-aminopropyltriethoxysilane, (the same compound as disclosed in the instant application). Yu discloses methacryloxy group, isocyanate groups, thiol groups, methoxy groups, and ethoxy groups (pg. 3 col. 2 para 1; 3-aminopropyltriethoxysilane). Yu does not specifically disclose utilizing mechanochemical synthesis for homogenizing the first mixture. However, in view of the above disclosure, it would have been obvious for the person of ordinary skill in the art to adjust the above preparation protocol, in the course of routine experimentation, and utilize the said technique, in order to enhance homogeneity of the prepared mixture before the casting step. Yu does not specifically disclose wherein the inherent antimicrobial properties include antimicrobial efficacy against gram-positive and gram-negative bacteria, fungi, and viruses is greater than 90%. However, in view of the above disclosure, it would have been obvious for the person of ordinary skill in the art to adjust the said efficacy to be within the specified range, in the course of routine experimentation, in order to better disinfect the media in need of the said disinfection. Correspondence Any inquiry concerning this communication or earlier communications from the examiner should be directed to SNIGDHA MAEWALL whose telephone number is (571)272-6197. The examiner can normally be reached Monday thru Friday; 8:30 AM to 5PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Frederick Krass can be reached on 571-272-0580. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /SNIGDHA MAEWALL/Primary Examiner, Art Unit 1612
Read full office action

Prosecution Timeline

Jan 30, 2023
Application Filed
Aug 09, 2025
Non-Final Rejection — §103
Nov 12, 2025
Response after Non-Final Action
Nov 12, 2025
Response Filed

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
58%
Grant Probability
69%
With Interview (+10.2%)
3y 4m
Median Time to Grant
Low
PTA Risk
Based on 1044 resolved cases by this examiner. Grant probability derived from career allow rate.

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