Prosecution Insights
Last updated: July 17, 2026
Application No. 18/020,317

PROCESS FOR PREPARATION OF SUBSTITUTED PYRAZOLES

Final Rejection §101§112
Filed
Feb 08, 2023
Priority
Aug 24, 2020 — provisional 63/069,539 +1 more
Examiner
JACKSON, SHAWQUIA
Art Unit
1626
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Bob Chen
OA Round
2 (Final)
78%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
75%
With Interview

Examiner Intelligence

Grants 78% — above average
78%
Career Allowance Rate
1419 granted / 1820 resolved
+18.0% vs TC avg
Minimal -3% lift
Without
With
+-3.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 3m
Avg Prosecution
45 currently pending
Career history
1851
Total Applications
across all art units

Statute-Specific Performance

§101
1.8%
-38.2% vs TC avg
§103
12.3%
-27.7% vs TC avg
§102
11.0%
-29.0% vs TC avg
§112
62.6%
+22.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1820 resolved cases

Office Action

§101 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Claims 1-13 and 16-20 are currently pending in the instant application. Applicants have amended claims 1, 7, 9, 11, 13 and 16-20 in an amendment filed on March 30, 2026. Claims 16-20 are rejected and claims 1-13 are considered allowable in this Office Action. I. Response to Remarks Applicants’ amendment, filed on March 30, 2026, has overcome the rejection of claims 16-20 under 35 USC 112(b) as being incomplete for omitting essential steps; the rejection of claims 7-11 under 35 USC 112(b) as failing to define the compound of formula I; the rejection of claims 7-11 under 35 USC 112(b) as lacking antecedent basis for “the compound of formula (I)”; the objection of claims 1, 13 and 16-20 for informalities. The above rejections and objection have been withdrawn. II. Rejection(s) Claim Rejections - 35 USC § 112 The following is a quotation of the second paragraph of 35 U.S.C. 112: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 16-20 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claims 16-20 have been amended to include the limitation “wherein the improvement comprises” but there is no mention of “an improvement” previously in the claims. It is unclear what “improvement” Applicants are referring to. The limitation lack antecedent basis. Applicants are suggested to amend the claim to delete the phrase “the improvement” to overcome the rejection. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 16-20 are rejected under 35 U.S.C. 101 because the claimed invention is directed to non-statutory subject matter. The phrase “In a method for preparing…” is written in improper format because a “in a method” can only be properly claimed as a process or method. It is suggested that applicant amend the claims by rewriting the claims as a process or method, i.e. “A method for preparing” in each of claims 16-20 to overcome the rejection. III. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Shawquia Jackson whose telephone number is (571)272-9043. The examiner can normally be reached on M-F 7AM-4PM. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Adam Milligan can be reached on 571-270-7674. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). /SHAWQUIA JACKSON/Primary Examiner, Art Unit 1626
Read full office action

Prosecution Timeline

Feb 08, 2023
Application Filed
Sep 30, 2025
Non-Final Rejection mailed — §101, §112
Mar 30, 2026
Response Filed
Jun 11, 2026
Final Rejection mailed — §101, §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12668571
SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28
3y 4m to grant Granted Jun 30, 2026
Patent 12662458
SOLID FORMS OF A COMPOUND
3y 0m to grant Granted Jun 23, 2026
Patent 12655117
PREPARATION OF SUBSTITUTED AROMATIC CARBOXAMIDES
4y 0m to grant Granted Jun 16, 2026
Patent 12655126
IMIDAZOLE-PYRAZOLE DERIVATIVES AS ANTIBACTERIALS
3y 3m to grant Granted Jun 16, 2026
Patent 12655140
Compound containing structure of a heteroaromatic ring, pharmaceutical composition thereof and application thereof
2y 9m to grant Granted Jun 16, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
78%
Grant Probability
75%
With Interview (-3.4%)
2y 3m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1820 resolved cases by this examiner. Grant probability derived from career allowance rate.

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