Prosecution Insights
Last updated: April 19, 2026
Application No. 18/023,211

KAEMPFEROL AGLYCONE-CONTAINING EXTRACT

Non-Final OA §102
Filed
Feb 24, 2023
Examiner
DAHLIN, HEATHER RAQUEL
Art Unit
1629
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Otsuka Pharmaceutical Co. Ltd.
OA Round
1 (Non-Final)
46%
Grant Probability
Moderate
1-2
OA Rounds
3y 5m
To Grant
97%
With Interview

Examiner Intelligence

Grants 46% of resolved cases
46%
Career Allow Rate
61 granted / 133 resolved
-14.1% vs TC avg
Strong +51% interview lift
Without
With
+50.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 5m
Avg Prosecution
83 currently pending
Career history
216
Total Applications
across all art units

Statute-Specific Performance

§101
4.6%
-35.4% vs TC avg
§103
33.3%
-6.7% vs TC avg
§102
19.8%
-20.2% vs TC avg
§112
25.7%
-14.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 133 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority This Application is a 371 of PCT/JP2021/030890, and claims foreign priority to JP2020-211979 and JP2020-141876, filed Dec. 22, 2020 and Aug. 25, 2020 in Japan. Information Disclosure Statement The information disclosure statements (IDS) submitted on June 16, 2025; Nov. 5, 2024; Sept. 27, 2024; and May 24, 2023 are in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statements are being considered by the examiner. Claim Status – Response to Restriction/ Election Requirement Claims 1-13 are currently pending. Applicant’s election without traverse of Group I, claims 1-4, in the reply filed on Dec. 29, 2025 is acknowledged. Claims 1-4 are currently pending and subject to examination. Claims 3-13 are withdrawn. Applicant is reminded that upon the cancelation of claims to a non-elected invention, the inventorship must be corrected in compliance with 37 CFR 1.48(a) if one or more of the currently named inventors is no longer an inventor of at least one claim remaining in the application. A request to correct inventorship under 37 CFR 1.48(a) must be accompanied by an application data sheet in accordance with 37 CFR 1.76 that identifies each inventor by his or her legal name and by the processing fee required under 37 CFR 1.17(i). Claim Rejections – 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: “A person shall be entitled to a patent unless - (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention.” Claim(s) 1, 3 and 4 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Rha et al. (Antioxidants, Vol. 8, Issue 8, August 5, 2019, p. 1-15). Claim 1 is directed towards a plant extract comprising a kaempferol aglycone in an amount of 1 mg/g or more on a dry-weight basis. Rha teaches a plant extract from green tea comprising kaempferol aglycone in an amount of 34.71 + 1.19 on a dry weight basis: PNG media_image1.png 421 620 media_image1.png Greyscale Rha, page 7. Therefore, claim 1 is anticipated. Claims 3 and 4 are duplicates and are directed towards the plant extract of claim 1, further comprising quercetin in an amount of 0.1 mg/g or more on a dry-weight basis. As shown in Table 2 of Rha presented in the rejection of claim 1, the FLA extract comprises quercetin in an amount of 38.21 mg/g on a dry weight basis. Therefore, claims 3-4 are anticipated. Claim(s) 1 and 2 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Park et al. (J. Agric. Food Chem., 2006, Vol. 54, Issue 8, p. 2951−2956). Claim 1 is directed towards a plant extract comprising a kaempferol aglycone in an amount of 1 mg/g or more on a dry-weight basis. Claim 2 is directed towards the plant extract of claim 1, comprising the kaempferol aglycone in an amount of 100 mg/g or more. Park teaches green tea seeds extracts (GTSE) comprising 20% (w/w) and 95% (w/w) of kaempferol aglycone which are equivalent to 200 mg/g and 950 mg/g on a dry weight basis: PNG media_image2.png 159 341 media_image2.png Greyscale Park, col. 2, p. 2954; PNG media_image3.png 190 339 media_image3.png Greyscale Park, col. 1, p. 2955. Therefore, claims 1-2 are anticipated. Duplicate Claims Applicant is advised that should claim 3 be found allowable, claim 4 will be objected to under 37 CFR 1.75 as being a substantial duplicate thereof. When two claims in an application are duplicates or else are so close in content that they both cover the same thing, despite a slight difference in wording, it is proper after allowing one claim to object to the other as being a substantial duplicate of the allowed claim. See MPEP § 608.01(m). Conclusion No claim is found to be allowable. Any inquiry concerning this communication or earlier communications from the examiner should be directed to HEATHER DAHLIN whose telephone number is (571)270-0436. The examiner can normally be reached 9-5. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey Lundgren can be reached on (571) 272-5541. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 86-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /HEATHER DAHLIN/Examiner, Art Unit 1629
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Prosecution Timeline

Feb 24, 2023
Application Filed
Jan 16, 2026
Non-Final Rejection — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
46%
Grant Probability
97%
With Interview (+50.7%)
3y 5m
Median Time to Grant
Low
PTA Risk
Based on 133 resolved cases by this examiner. Grant probability derived from career allow rate.

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