DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Claim 1 is pending and under examination.
Claim Rejections - 35 USC § 102
The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action:
A person shall be entitled to a patent unless –
(a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention.
Claim(s) 1 is rejected under 35 U.S.C. 102(a)(1) as being anticipated by Hossain et al. (JACS, 2020, 1164-1169, published 12/18/2019).
The instantly claimed invention is broadly drawn to a method for glycosylating a peptide or protein, comprising the steps of: a) providing a peptide or protein comprising an amino acid residue comprising an unprotected nucleophilic group; and b) reacting the nucleophilic group with a glycosyl moiety substituted with a leaving group to provide a glycosylated peptide or protein.
Hossain et. al. teach that glycosylation is an accepted strategy to improve therapeutic valued of a peptide or protein drug (abstract). They teach inserting a cysteine amino acid to insulin molecule and then attaching a sialic acid sugar to glycosylate the insulin molecule (Figure 1A). Cysteine comprises unprotected nucleophilic group which reacts with glycosyl moiety resulting in glycosylated insulin molecule. Therefore, the instantly claimed invention is implicitly or explicitly anticipated by the prior art.
Conclusion
Claim 1 is rejected.
Any inquiry concerning this communication or earlier communications from the examiner should be directed to GYAN CHANDRA whose telephone number is (571)272-2922. The examiner can normally be reached Mon-Friday 8:30AM-5:00P.
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/GYAN CHANDRA/Primary Examiner, Art Unit 1674
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