Prosecution Insights
Last updated: August 06, 2026
Application No. 18/033,964

MATRIX METALLOPROTEASE 1 EXPRESSION INHIBITOR, SKIN EXTERNAL AGENT, AND USE FOR INHIBITION OF MATRIX METALLOPROTEASE 1 EXPRESSION

Final Rejection §102
Filed
Nov 03, 2023
Priority
Oct 28, 2020 — JP 2020-180871 +1 more
Examiner
CHEN, CATHERYNE
Art Unit
1655
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Dsr Corporation
OA Round
2 (Final)
37%
Grant Probability
At Risk
3-4
OA Rounds
1y 6m
Est. Remaining
56%
With Interview

Examiner Intelligence

Grants only 37% of cases
37%
Career Allowance Rate
292 granted / 780 resolved
-22.6% vs TC avg
Strong +18% interview lift
Without
With
+18.3%
Interview Lift
resolved cases with interview
Typical timeline
4y 3m
Avg Prosecution
57 currently pending
Career history
836
Total Applications
across all art units

Statute-Specific Performance

§101
14.6%
-25.4% vs TC avg
§103
41.4%
+1.4% vs TC avg
§102
18.2%
-21.8% vs TC avg
§112
19.4%
-20.6% vs TC avg
Black line = Tech Center average estimate • Based on career data from 780 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION The Amendments filed on 4/8/2026 has been received and entered. Claims 11-21 are pending. Claims 11-21 are examined on the merits. The text of those sections of Title 35, U.S. Code not included in this action can be found in a prior Office action. Any rejection not reiterated below are hereby withdrawn. Election/Restrictions Applicant’s election of the species an extract of hops in the reply filed on 11/24/2025 is acknowledged. Because applicant did not distinctly and specifically point out the supposed errors in the restriction requirement, the election has been treated as an election without traverse (MPEP § 818.01(a)). Information Disclosure Statement The information disclosure statements (IDSs) submitted on 12/8/2025, 7/25/2025, 5/12/2023, 4/26/2023 are in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statements are being considered by the examiner. The signed IDS forms are attached with the instant office action. Response to Amendment Claim Rejections - 35 USC § 102 Claim(s) 11-21 are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Li et al. (CN 111135133 A). This is not a new rejection but with slight modification. Li et al. teaches a method of using cosmetic preparation using beer brewing residue extract comprising 1% hops extract in deionized water (page 6, Example 6). Water can be a base for cosmetics. The cosmetics is applied to skin (Table 4). The same hops extract would have the same effect at the same concentration and same application to skin. The mechanism of inhibiting protein kinas C-delta induced by ultraviolet A irradiation would inherently occur when the same composition is applied on skin and the subject is exposed to the sun. Therefore, the reference anticipates the claims. Response to Arguments Applicant argues that Li et al. does not teach inhibition of protein kinase C-delta pathway. In response to Applicant’s argument, Li et al. teaches a method of using cosmetic preparation using beer brewing residue extract comprising 1% hops extract in deionized water (page 6, Example 6). The cosmetics is applied to skin (Table 4). A disclosure of the exact mechanism of action is not required. The reference specifically claims using hops extract in a composition for skin moisturizing. The reference gives the activity and the appropriate dosage amount to treat skin dryness. Therefore, an artisan of ordinary skill would clearly see that this reference shows that using hops extract to treat skin dryness was known in the art at the time of the invention. Conclusion THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to CATHERYNE CHEN whose telephone number is (571)272-9947. The examiner can normally be reached Monday-Friday 9-5:30 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Anand U Desai can be reached at 571-272-0947. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. Catheryne Chen Examiner Art Unit 1655 /ANAND U DESAI/Supervisory Patent Examiner, Art Unit 1655
Read full office action

Prosecution Timeline

Nov 03, 2023
Application Filed
Apr 26, 2023
Response after Non-Final Action
Oct 02, 2025
Applicant Interview (Telephonic)
Oct 02, 2025
Examiner Interview Summary
Jan 12, 2026
Non-Final Rejection mailed — §102
Apr 08, 2026
Response Filed
Jun 26, 2026
Final Rejection mailed — §102 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
37%
Grant Probability
56%
With Interview (+18.3%)
4y 3m (~1y 6m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 780 resolved cases by this examiner. Grant probability derived from career allowance rate.

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