Office Action Predictor
Last updated: April 15, 2026
Application No. 18/037,107

COMPOSITION FOR ENHANCING ADRENOMEDULLIN GENE EXPRESSION

Non-Final OA §102
Filed
May 16, 2023
Examiner
PIHONAK, SARAH
Art Unit
1627
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
House Wellness Foods Corporation
OA Round
1 (Non-Final)
61%
Grant Probability
Moderate
1-2
OA Rounds
2y 9m
To Grant
99%
With Interview

Examiner Intelligence

Grants 61% of resolved cases
61%
Career Allow Rate
900 granted / 1477 resolved
+0.9% vs TC avg
Strong +59% interview lift
Without
With
+59.2%
Interview Lift
resolved cases with interview
Typical timeline
2y 9m
Avg Prosecution
47 currently pending
Career history
1524
Total Applications
across all art units

Statute-Specific Performance

§101
1.7%
-38.3% vs TC avg
§103
40.0%
+0.0% vs TC avg
§102
11.0%
-29.0% vs TC avg
§112
20.5%
-19.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1477 resolved cases

Office Action

§102
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority This application, filed 05/16/2023 is a National Stage entry of PCT/JP2021/042112, International Filing Date: 11/16/2021. PCT/JP2021/042112 claims foreign priority to 2020-189986, filed 11/16/2020. A certified copy of the foreign priority application is of record. Status of Claims Claims 1-3 are currently pending. Claims 1-3 were examined and are rejected. Claim Rejections-35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1-3 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Westphal et. al., WO 2017062665 A1, publ. 4/13/2017. Westphal discloses compositions having activity for treating muscle cramps, muscle spasms, spasticity, dystonias, and fasciculations (title & abstract). In particular, Westphal discloses the combination of the TRPV1 activator capsaicin and the TRPA1 activator, cinnamaldehyde (Ex. 1, bridging para pp. 88-89; pp. 90-91, Table 1, see treatment F). Regarding the recitation in the preamble of claim 1, “for enhancing adrenomedullin gene expression”, this statement is drawn to intended use of the composition. If the preamble limitations don’t impart structural limitations to the claim, and the body of the claim fully sets forth the structural limitations, the statement of intended use doesn’t further limit the claim. See MPEP 2111.02(II): If the body of a claim fully and intrinsically sets forth all of the limitations of the claimed invention, and the preamble merely states, for example, the purpose or intended use of the invention, rather than any distinct definition of any of the claimed invention’s limitations, then the preamble is not considered a limitation and is of no significance to claim construction. Shoes by Firebug LLC v. Stride Rite Children’s Grp., LLC, 962 F.3d 1362, 2020 USPQ2d 10701 (Fed. Cir. 2020) (The court found that the preamble in one patent’s claim is limiting but is not in a related patent); Pitney Bowes, Inc. v. Hewlett-Packard Co., 182 F.3d 1298, 1305, 51 USPQ2d 1161, 1165 (Fed. Cir. 1999). See also Rowe v. Dror, 112 F.3d 473, 478, 42 USPQ2d 1550, 1553 (Fed. Cir. 1997) ("where a patentee defines a structurally complete invention in the claim body and uses the preamble only to state a purpose or intended use for the invention, the preamble is not a claim limitation"); Kropa v. Robie, 187 F.2d at 152, 88 USPQ2d at 480-81 (preamble is not a limitation where claim is directed to a product and the preamble merely recites a property inherent in an old product defined by the remainder of the claim); STX LLC. v. Brine, 211 F.3d 588, 591, 54 USPQ2d 1347, 1350 (Fed. Cir. 2000) (holding that the preamble phrase "which provides improved playing and handling characteristics" in a claim drawn to a head for a lacrosse stick was not a claim limitation). As Westphal discloses a composition comprising the same combination of TRPV1 agonist and TRPA1 agonist as claimed, and the preamble of claim 1 doesn’t further limit the claim, Westphal anticipates the claims. Claim(s) 1-3 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Wang et. al., CN 111296841 A, publ. 6/19/2020. An English translation of Wang is provided and is referred to for discussion. Wang discloses a composition for preventing and controlling cold damage comprising 6-gingerol, piperine, and cinnamaldehyde (abstract; para [0010-0012]; p. 35 of 38, claim 1). Wang discloses the composition increases the body’s heat production effect, exhibits a synergistic effect, and has no toxic side effects (para [0008]). Therefore, Wang discloses a composition comprising the combination of the TRPV1 agonists 6-gingerol and piperine, and the TRPA1 agonist, cinnamaldehyde. Regarding the recitation in the preamble of claim 1, “for enhancing adrenomedullin gene expression”, this statement is drawn to intended use of the composition. If the preamble limitations don’t impart structural limitations to the claim, and the body of the claim fully sets forth the structural limitations, the statement of intended use doesn’t further limit the claim. See MPEP 2111.02(II): If the body of a claim fully and intrinsically sets forth all of the limitations of the claimed invention, and the preamble merely states, for example, the purpose or intended use of the invention, rather than any distinct definition of any of the claimed invention’s limitations, then the preamble is not considered a limitation and is of no significance to claim construction. Shoes by Firebug LLC v. Stride Rite Children’s Grp., LLC, 962 F.3d 1362, 2020 USPQ2d 10701 (Fed. Cir. 2020) (The court found that the preamble in one patent’s claim is limiting but is not in a related patent); Pitney Bowes, Inc. v. Hewlett-Packard Co., 182 F.3d 1298, 1305, 51 USPQ2d 1161, 1165 (Fed. Cir. 1999). See also Rowe v. Dror, 112 F.3d 473, 478, 42 USPQ2d 1550, 1553 (Fed. Cir. 1997) ("where a patentee defines a structurally complete invention in the claim body and uses the preamble only to state a purpose or intended use for the invention, the preamble is not a claim limitation"); Kropa v. Robie, 187 F.2d at 152, 88 USPQ2d at 480-81 (preamble is not a limitation where claim is directed to a product and the preamble merely recites a property inherent in an old product defined by the remainder of the claim); STX LLC. v. Brine, 211 F.3d 588, 591, 54 USPQ2d 1347, 1350 (Fed. Cir. 2000) (holding that the preamble phrase "which provides improved playing and handling characteristics" in a claim drawn to a head for a lacrosse stick was not a claim limitation). As Wang discloses a composition comprising the same combination of TRPV1 agonist and TRPA1 agonist as claimed, and the preamble of claim 1 doesn’t further limit the claim, Wang anticipates the claims. Information Disclosure Statements The IDS filed on 5/16/23, 7/10/23, 7/26/23, 7/24/25, and 7/28/25 have been considered. Conclusion Claims 1-3 are rejected. Any inquiry concerning this communication or earlier communications from the examiner should be directed to SARAH PIHONAK whose telephone number is (571)270-7710. The examiner can normally be reached Monday-Friday 9:00-5:30 EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Kortney Klinkel can be reached at 571-270-5239. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. SARAH . PIHONAK Primary Examiner Art Unit 1627 /SARAH PIHONAK/Primary Examiner, Art Unit 1627
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Prosecution Timeline

May 16, 2023
Application Filed
Aug 28, 2025
Non-Final Rejection — §102
Mar 31, 2026
Response after Non-Final Action

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
61%
Grant Probability
99%
With Interview (+59.2%)
2y 9m
Median Time to Grant
Low
PTA Risk
Based on 1477 resolved cases by this examiner. Grant probability derived from career allow rate.

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