Last updated: May 29, 2026

Application No. 18/054,469

Dumbbell PCR: A Method To Quantify Specific Small RNA Variants With A Single Nucleotide Resolution At Terminal Sequences

Non-Final OA

Filed

Nov 10, 2022

Priority

Aug 21, 2015 — provisional 62/208,183 +3 more

Examiner

BERTAGNA, ANGELA MARIE

Art Unit

1681

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Thomas Jefferson University

OA Round

1 (Non-Final)

This examiner grants 44% of cases after interview

— +46.3% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 706 resolved cases, 2023–2026

Examiner Intelligence

BERTAGNA, ANGELA MARIE View full profile →

Grants 44% of resolved cases

Career Allowance Rate

314 granted / 706 resolved

-15.5% vs TC avg

Strong +46% interview lift

Without

With

+46.3%

Interview Lift

resolved cases with interview

Typical timeline

3y 10m

Avg Prosecution

21 currently pending

Career history

735

Total Applications

across all art units

Statute-Specific Performance

§101

1.1%

-38.9% vs TC avg

§103

62.7%

+22.7% vs TC avg

§102

7.0%

-33.0% vs TC avg

§112

15.6%

-24.4% vs TC avg

Black line = Tech Center average estimate • Based on career data from 706 resolved cases

Prosecution Timeline

Nov 10, 2022

Application Filed

Apr 03, 2023

Response after Non-Final Action

Sep 11, 2025

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

16/980,657

Patent 12584165

Method for Identifying One or More Mutations in a Hotspot Mutation Sequence

5y 6m to grant Granted Mar 24, 2026

17/441,842

Patent 12545943

METHODS OF DETECTING MICROBIAL CONTENT IN CANNABIS

4y 4m to grant Granted Feb 10, 2026

17/684,328

Patent 12545952

AMPLICON-BASED SEQUENCING USING DNA SPIKE-INS

3y 11m to grant Granted Feb 10, 2026

17/003,388

Patent 12527665

CLASSIFICATION OF NUCLEIC ACID TEMPLATES

5y 4m to grant Granted Jan 20, 2026

17/412,087

Patent 12522866

PRE-AMPLIFICATION ASSAY

4y 4m to grant Granted Jan 13, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

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Prosecution Projections

1-2

Expected OA Rounds

44%

Grant Probability

91%

With Interview (+46.3%)

3y 10m (~4m remaining)

Median Time to Grant

Low

PTA Risk

Based on 706 resolved cases by this examiner. Grant probability derived from career allowance rate.