Prosecution Insights
Last updated: July 14, 2026
Application No. 18/131,450

TRANSTHYRETIN TETRAMER STABILIZING AGENT, AND PREVENTING AGENT OR PROGRESSION SUPPRESSING AGENT FOR TRANSTHYRETIN AMYLOIDOSIS

Non-Final OA §102
Filed
Apr 06, 2023
Priority
Oct 07, 2020 — JP 2020-169831 +1 more
Examiner
HUI, SAN MING R
Art Unit
1627
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
National University Corporation Kumamoto University
OA Round
1 (Non-Final)
59%
Grant Probability
Moderate
1-2
OA Rounds
0m
Est. Remaining
79%
With Interview

Examiner Intelligence

Grants 59% of resolved cases
59%
Career Allowance Rate
768 granted / 1299 resolved
-0.9% vs TC avg
Strong +20% interview lift
Without
With
+19.9%
Interview Lift
resolved cases with interview
Typical timeline
2y 11m
Avg Prosecution
40 currently pending
Career history
1347
Total Applications
across all art units

Statute-Specific Performance

§101
0.9%
-39.1% vs TC avg
§103
58.8%
+18.8% vs TC avg
§102
5.7%
-34.3% vs TC avg
§112
9.2%
-30.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1299 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Applicant's election with traverse of the invention of group II, claims 13, 17-18, in the reply filed on 1/2/2026 is acknowledged. The traversal is on the ground(s) that no serious burden would be imposed to the examiner. This is not found persuasive because searching for different and distinct patentable subject matters encompassed by the claims does impose undue burden to the examiner. As the scope of the patentably distinct invention not necessarily being overlapped, searching for one invention would may not be searching for other inventions. In addition, searching is not limited to patent files. Accordingly, it imposes undue burden to the examiner. The requirement is still deemed proper and is therefore made FINAL. Claims 1-12 and 14-16 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a nonelected invention, there being no allowable generic or linking claim. Applicant timely traversed the restriction (election) requirement in the reply filed on 1/2/2026. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 13, 17-18 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Shinichi et al. (JP2007063161), from IDS filed 4/6/2023. Shinichi et al. teaches the use of the hydrophobic extract of licorice to treat diseases caused by the expression of the acute phase reactant (see the abstract). Shinichi et al. teaches the hydrophobic extract of licorice containing flavonoids such as glabrene, glabridin, glabrol, and 4’-O-methylglabridin (see [0040]). Shinichi et al. teaches the dosage to be 0.1 to 100/kg body weight (see [0045], last paragraph). The preventive properties of the licorice extract composition would be considered inherently present in the method of administering the composition containing hydrophobic extract of licorice. No claims are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to SAN MING R HUI whose telephone number is (571)272-0626. The examiner can normally be reached Mon - Fri 9:30-5:30. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Kortney Klinkel can be reached at 571-270-5239. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /SAN MING R HUI/Primary Examiner, Art Unit 1627
Read full office action

Prosecution Timeline

Apr 06, 2023
Application Filed
Apr 09, 2026
Non-Final Rejection mailed — §102
Jun 23, 2026
Examiner Interview Summary
Jun 23, 2026
Applicant Interview (Telephonic)

Precedent Cases

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DRY POWDER FORMULATION FOR PULMONARY DELIVERY AND METHODS OF USE
3y 9m to grant Granted Jun 30, 2026
Patent 12668590
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3y 1m to grant Granted Jun 30, 2026
Patent 12667561
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2y 10m to grant Granted Jun 30, 2026
Patent 12661347
SYSTEMIC FORMULATION OF A PYRIDINONE DERIVATE FOR COELIAC DISEASE
3y 8m to grant Granted Jun 23, 2026
Patent 12661363
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2y 4m to grant Granted Jun 23, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
59%
Grant Probability
79%
With Interview (+19.9%)
2y 11m (~0m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1299 resolved cases by this examiner. Grant probability derived from career allowance rate.

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