Last updated: May 29, 2026

Application No. 18/183,002

METHODS OF ANALYZING NUCLEIC ACID FRAGMENTS

Non-Final OA

Filed

Mar 13, 2023

Priority

Aug 10, 2016 — provisional 62/373,332 +2 more

Examiner

WILDER, CYNTHIA B

Art Unit

1681

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Grail, Inc.

OA Round

1 (Non-Final)

Interview Optional

— +26.6% interview lift. Examiner has a relatively high allowance rate (71%); +26.6% interview lift. A written response may suffice.

Based on 900 resolved cases, 2023–2026

Examiner Intelligence

WILDER, CYNTHIA B View full profile →

Grants 71% — above average

Career Allowance Rate

638 granted / 900 resolved

+10.9% vs TC avg

Strong +27% interview lift

Without

With

+26.6%

Interview Lift

resolved cases with interview

Typical timeline

3y 0m

Avg Prosecution

35 currently pending

Career history

944

Total Applications

across all art units

Statute-Specific Performance

§101

2.5%

-37.5% vs TC avg

§103

60.2%

+20.2% vs TC avg

§102

11.0%

-29.0% vs TC avg

§112

10.8%

-29.2% vs TC avg

Black line = Tech Center average estimate • Based on career data from 900 resolved cases

Prosecution Timeline

Mar 13, 2023

Application Filed

Apr 24, 2023

Response after Non-Final Action

Sep 04, 2025

Non-Final Rejection mailed

Feb 24, 2026

Response Filed

Feb 24, 2026

Response after Non-Final Action

Precedent Cases

Applications granted by this same examiner with similar technology

17/898,112

Patent 12630871

METHODS AND SYSTEMS FOR DETECTING TISSUE CONDITIONS

3y 8m to grant Granted May 19, 2026

18/003,456

Patent 12630861

PROTECTION METHOD, PROTECTION SEQUENCE, COMPOSITION AND KIT FOR PREVENTING RNA DEGREADATION, AND USE THEREOF

3y 4m to grant Granted May 19, 2026

18/166,986

Patent 12630866

METHODS FOR ANALYZING NUCLEIC ACIDS

3y 3m to grant Granted May 19, 2026

17/715,894

Patent 12618795

METHODS FOR ASYMMETRIC SEMI-NESTED ISOTHERMAL NUCLEOTIDE AMPLIFICATION

4y 0m to grant Granted May 05, 2026

17/913,352

Patent 12612662

DNA REPAIR SITE DETECTION FOR PERSONAL GENOMICS, EPIGENOMICS, AND GENE THERAPY

3y 7m to grant Granted Apr 28, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2

Expected OA Rounds

71%

Grant Probability

98%

With Interview (+26.6%)

3y 0m (~0m remaining)

Median Time to Grant

Low

PTA Risk

Based on 900 resolved cases by this examiner. Grant probability derived from career allowance rate.