Prosecution Insights
Last updated: May 29, 2026
Application No. 18/187,377

THERAPEUTIC MOLECULES

Final Rejection §112
Filed
Mar 21, 2023
Priority
Feb 09, 2023 — GB 2301838.5 +1 more
Examiner
CHEONG, CHEOM-GIL
Art Unit
1645
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Petmedix Ltd.
OA Round
4 (Final)
65%
Grant Probability
Favorable
5-6
OA Rounds
1m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 65% — above average
65%
Career Allowance Rate
117 granted / 180 resolved
+5.0% vs TC avg
Strong +54% interview lift
Without
With
+54.4%
Interview Lift
resolved cases with interview
Typical timeline
3y 3m
Avg Prosecution
27 currently pending
Career history
212
Total Applications
across all art units

Statute-Specific Performance

§101
1.4%
-38.6% vs TC avg
§103
31.9%
-8.1% vs TC avg
§102
9.8%
-30.2% vs TC avg
§112
21.6%
-18.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 180 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Status Claims 2-6, 8-20, 22, 24-28 and 30 are canceled. Claims 1, 7, 21, 23 and 29 are pending. Claim 23 stays withdrawn from further consideration. Claims 1, 7, 21 and 29 and under consideration. Withdrawn Rejections Rejection of Claims 1, 7, 21 and 29 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention is withdrawn. Applicant amended the claim 1 to recite specific sequence of SEQ ID NO: 87 or 94 for the isolated polypeptide, thereby obviating this rejection/objection. Rejection of Claim 1-7, 21 and 29 under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement is withdrawn. Applicant amended the claim 1 to recite specific sequence of SEQ ID NO: 87 or 94 for the isolated polypeptide, thereby obviating this rejection/objection. MAINTAINED - Specification The title of the invention is not descriptive. A new title is required that is clearly indicative of the invention to which the claims are directed. The following title is suggested: Therapeutic molecules comprising a variant of human p75NTR extracellular domain. NEW - Claim Rejections - 35 USC § 112 (necessitated by amendments) The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claim 7 is rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Amended claim 1 now recites specific sequences of SEQ ID NO: 87 or 94 which already contains truncated extracellular domain of p75NTR. Claim 7 depends from claim 1 and therefore claim 7 fails to further limit the subject matter of the claim upon which it depends. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Conclusion Claims 1, 21 and 29 are allowed. Claim 7 is rejected. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to CHEOM-GIL CHEONG whose telephone number is (571)272-6251. The examiner can normally be reached Monday - Friday 9:00 am - 5:00 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Vanessa Ford can be reached at 571-272-0857. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /CHEOM-GIL CHEONG/Examiner, Art Unit 1645 /VANESSA L. FORD/Supervisory Patent Examiner, Art Unit 1674
Read full office action

Prosecution Timeline

Show 2 earlier events
Nov 04, 2024
Response Filed
Dec 11, 2024
Final Rejection mailed — §112
Jun 11, 2025
Request for Continued Examination
Jun 12, 2025
Response after Non-Final Action
Jul 23, 2025
Examiner Interview (Telephonic)
Aug 06, 2025
Non-Final Rejection mailed — §112
Dec 05, 2025
Response Filed
Jan 09, 2026
Final Rejection mailed — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

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TRANSMISSION-BLOCKING VACCINE AGAINST BABESIA
3y 8m to grant Granted May 26, 2026
Patent 12624119
ISOLATED ANTIGEN-BINDING PROTEIN AND APPLICATION THEREOF
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Patent 12558408
INTRATUMORALLY INJECTED YEAST VACCINE
2y 11m to grant Granted Feb 24, 2026
Patent 12559536
CD33 SPECIFIC CHIMERIC ANTIGEN RECEPTORS
2y 5m to grant Granted Feb 24, 2026
Patent 12540192
CD20 BINDING SINGLE DOMAIN ANTIBODIES
4y 1m to grant Granted Feb 03, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
65%
Grant Probability
99%
With Interview (+54.4%)
3y 3m (~1m remaining)
Median Time to Grant
High
PTA Risk
Based on 180 resolved cases by this examiner. Grant probability derived from career allowance rate.

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