Prosecution Insights
Last updated: April 19, 2026
Application No. 18/226,226

Application of Aristolochic Acid IVa in Preparation of Antihistamine or Drug for Treating Pneumonia

Final Rejection §101§102§103§112
Filed
Jul 25, 2023
Examiner
OH, TAYLOR V
Art Unit
1625
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Institute Of Chinese Materia Medica China Academy Of Chinese Medical Sciences
OA Round
2 (Final)
81%
Grant Probability
Favorable
3-4
OA Rounds
2y 5m
To Grant
96%
With Interview

Examiner Intelligence

Grants 81% — above average
81%
Career Allow Rate
1415 granted / 1742 resolved
+21.2% vs TC avg
Strong +15% interview lift
Without
With
+15.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 5m
Avg Prosecution
35 currently pending
Career history
1777
Total Applications
across all art units

Statute-Specific Performance

§101
0.4%
-39.6% vs TC avg
§103
33.6%
-6.4% vs TC avg
§102
19.5%
-20.5% vs TC avg
§112
37.3%
-2.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1742 resolved cases

Office Action

§101 §102 §103 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Final Rejection The Status of Claims: Claims 1-9 are pending. Claims 1-9 are rejected. In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. Claim Objections The objection of Claim 8 is withdrawn due to the modification of Claim 8. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. The rejection of Claims 1-7 under 35 U.S.C. 101 is still maintained due to failure to modify the claims Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. The rejection of Claims 1-7 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, is still maintained due to the incomplete modification of the claims Furthermore, in view of the revised claims 1 and 8-9, another 112 second paragraph rejection seem necessary in the following: Claims 1, 3-9 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor, or for pre-AIA the applicant regards as the invention. In claims 1 and 8-9, the terms” aristolochic acid Iva” are recited. The claims do not define what kind of the chemical formula for ” aristolochic acid Iva”” is for the claims. The claims referring to the specification are improper. The claims should be complete by themselves. The examiner recommends to put the the specific chemical structure for the terms” aristolochic acid Iva” in the claims. Claim Rejections - 35 USC § 102 Applicants have filed the amendment on 1/13/26, some of them are persuasive , while others are not. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. The rejection of Claim 9 is rejected under 35 U.S.C. 102(a)(1) as being anticipated clearly by Liu et al (Hindawi Journal of Analytical Methods in Chemistry, Volume 2020, 19 November 2020, pages 1-7) is withdrawn due to the modification of claim. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The rejection of Claim 8 under 35 U.S.C. 103 as being unpatentable over Wikipedia (Antihistamines, November 2021, p. 1-11) in view of Liu et al (Hindawi Journal of Analytical Methods in Chemistry, Volume 2020, 19 November 2020, pages 1-7) ) is withdrawn due to the modification of claim. Applicants argue the following issues: Claim 1 is amended to involve a step "comprising using aristolochic acid IVa or a medically acceptable salt thereof as an active ingredient of the antihistamine or the drug". As such, the rejection is respectfully traversed. Claim 9 is rejected under 35 U.S.C. 102(a)(1) as being anticipated clearly by Liu et al (Hindawi Journal of Analytical Methods in Chemistry, Volume 2020, 19 November 2020, pages 1-7). Claim 8 is rejected under 35 U.S.C. 103 as being unpatentable over Wikipedia (Antihistamines, November 2021, p. 1-11) in view of Liu et al (Hindawi Journal of Analytical Methods in Chemistry, Volume 2020, 19 November 2020, pages 1-7). Regarding the the first argument, Applicants’ arguments have been noted. However, as indicated in the above, another 112 second paragraph rejection seems necessary. Also, the usage of the term “ An application of an aristolochic acid IVa “ in the beginning of the claims are not proper in US practice. The examiner recommends to change it into different forms ; for example , applicants may change it into the method claim or compound claim or some other types of the claims. Regarding the second and the third arguments, they are persuasive. But as indicated in the above, another 112 second paragraph rejection seems necessary. Therefore, applicants’ arguments are not completely persuasive. Conclusion Claims 1-9 are rejected. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to TAYLOR V OH whose telephone number is (571)272-0689. The examiner can normally be reached 8:00-5:00. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Andrew Kosar can be reached on 571-272-0913. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /TAYLOR V OH/Primary Examiner, Art Unit 1625 2/7/26
Read full office action

Prosecution Timeline

Jul 25, 2023
Application Filed
Oct 22, 2025
Non-Final Rejection — §101, §102, §103
Jan 13, 2026
Response Filed
Feb 07, 2026
Final Rejection — §101, §102, §103 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
81%
Grant Probability
96%
With Interview (+15.3%)
2y 5m
Median Time to Grant
Moderate
PTA Risk
Based on 1742 resolved cases by this examiner. Grant probability derived from career allow rate.

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