Prosecution Insights
Last updated: April 19, 2026
Application No. 18/248,380

NAIL POLISH REMOVER COMPRISING GLYCOLIPIDS

Final Rejection §103§112
Filed
Apr 08, 2023
Examiner
BABSON, NICOLE PLOURDE
Art Unit
1619
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Locus Solutions Ipco LLC
OA Round
2 (Final)
46%
Grant Probability
Moderate
3-4
OA Rounds
3y 8m
To Grant
78%
With Interview

Examiner Intelligence

Grants 46% of resolved cases
46%
Career Allow Rate
238 granted / 516 resolved
-13.9% vs TC avg
Strong +32% interview lift
Without
With
+31.8%
Interview Lift
resolved cases with interview
Typical timeline
3y 8m
Avg Prosecution
63 currently pending
Career history
579
Total Applications
across all art units

Statute-Specific Performance

§101
0.4%
-39.6% vs TC avg
§103
52.4%
+12.4% vs TC avg
§102
8.6%
-31.4% vs TC avg
§112
22.1%
-17.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 516 resolved cases

Office Action

§103 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION The Applicant’s reply filed on 12/9/25 is acknowledged. Claims 1-6, 9, and 12-24 are pending. Claims 16-24 have been withdrawn. Claims 1, 3, 5, 6, 12, 13 and 15 have been amended. Claims 1-6, 9 and 12-15 are under consideration. Rejections Withdrawn The rejection of Claims 1-6, 9 and 12-15 under 35 U.S.C. 103 as being unpatentable over Wallach et al. (WO 2018/140562) in view of Kitamoto et al. (Journal of Oleo Science; Jan 2022) is withdrawn in view of the amended claims. Rejections Maintained and New Grounds of Rejections Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 9 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 9 recites the limitation "said glycolipid" in line 2. There is insufficient antecedent basis for this limitation in the claim. Claim 1 does not recite “glycolipid”. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102 of this title, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries set forth in Graham v. John Deere Co., 383 U.S. 1, 148 USPQ 459 (1966), that are applied for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention. Claims 1, 2, 5, 6, 9, 12, 14 and 15 are rejected under 35 U.S.C. 103 as being unpatentable over Ramin et al. (US 2002/0012643) in view of De Oliveira et al. (Int. J. Adv. Biotechnol. Res., 2015; cited in IDS). Ramin et al. teach compositions for removing make-up from keratinous materials, including nail polish removal compositions comprising a removal solvent (e.g. abstract; paragraphs 0002; Examples 1 and 2; Claim 46). Ramin et al. teach that the compositions can further comprise a surfactant (e.g. paragraph 0040-0057) and preservatives (e.g. paragraph 0071), but does not teach that the surfactant is a sophorolipid. This is made up for by the teachings of De Oliveira et al. De Oliveira et al. teach that sophorolipids (SLP) are one of the most promising and attractive biosurfactants which combines green chemistry with lower carbon footprint, without the undesirable side products or environmental downsides associated with synthetic surfactants (e.g. page 161, column 2). De Oliveira teach that SLP have numerous properties that make them superior to synthetic surfactants including: stability in the wide range of pHs, temperatures, and salinity, low-foaming and excellent detergent properties, water hardness (high concentration of divalent cations) does not affect their interfacial properties, synergism between acidic and lactonic forms of SLP increase surfactants activities, are readily biodegradable and exhibit good surface activity (critical micelle concentration (CMC), surface tension and emulsification behavior). In addition, SLP can be produced in large quantities based on renewable resources, agro-industrial by-products and residues and easy and simplified product recovery (e.g. page 162, column 1). De Oliveira teach that SLP can act as an antibacterial agent, antialgal, antifungal, antimycoplasma, and antiviral agents (e.g. page 166, column 1). De Oliveira teach that SLPs are already in use for cosmetics (e.g. Table on page 163). Regarding Claim 1, it would have been obvious to one of ordinary skill in the art at the time of filing to include the sophorolipids of De Oliveira et al. in the nail polish remover composition of Ramin et al. It would have been obvious to one of ordinary skill in the art to combine the elements as claimed by known methods with no change in their respective functions, and the combination yielding nothing more than predictable results. One of ordinary skill in the art would have predicted success as Ramin et al. teach the addition of surfactants and preservatives, and one of ordinary skill would have been motivated in order to provide the benefits disclosed by De Oliveira et al. including stability, biodegradability, antimicrobial and production of large quantities based on renewable resources. Regarding Claims 2 and 6, Ramin et al. teach that the solvent is an acetate and the composition further comprises glycerol (e.g. paragraph 0034, Examples 1; Claim 46). Regarding Claim 5, the source of the acetate is a product-by-process limitation. Product-by-process claims are not limited to the manipulations of the recited steps, only the structure implied by the steps. In the instant case, an acetate, whether produced through biological fermentation or not, is structurally identical. If the product in the product-by-process claim is the same as or obvious from a product of the prior art, the claim is unpatentable even though the prior product was made by a different process.” In re Thorpe, 777 F.2d 695, 698, 227 USPQ 964, 966 (Fed. Cir. 1985). Regarding Claim 9, Ramin et al. teach that the surfactant is present at 0-10 wt% or 0.5-5 wt%, which overlap with the claimed range (e.g. paragraph 0057). In the case where the claimed ranges “overlap or lie inside ranges disclosed by the prior art” a prima facie case of obviousness exists. In re Wertheim, 541 F.2d 257, 191 USPQ 90 (CCPA 1976); In re Woodruff, 919 F.2d 1575, 16 USPQ2d 1934 (Fed. Cir. 1990) (MPEP 2144.05.I). Regarding Claims 12, 14 and 15, Ramin et al. teach the composition comprises: 0-10 wt% or 0.5-5 wt% of a surfactant (e.g. paragraph 0057); 0-99 wt% or 20-98 wt% of solvent, and further exemplify 77.5 wt% ethyl acetate or 83.5 wt% acetone (e.g. paragraph 0032 and 0034; Examples 1 and 2); 2 wt% of glycerol (e.g. Example 1 and 2); and 0.1-30 wt% of an aqueous phase, and further exemplify 4 wt% water (e.g. paragraph 0070; Example 1). The ranges of ingredients disclosed by Ramin et al. are within or overlap the claimed ranges. In the case where the claimed ranges “overlap or lie inside ranges disclosed by the prior art” a prima facie case of obviousness exists. In re Wertheim, 541 F.2d 257, 191 USPQ 90 (CCPA 1976); In re Woodruff, 919 F.2d 1575, 16 USPQ2d 1934 (Fed. Cir. 1990) (MPEP 2144.05.I). Claims 3, 4, and 13 are rejected under 35 U.S.C. 103 as being unpatentable over Ramin et al. (US 2002/0012643) in view of De Oliveira et al. (Int. J. Adv. Biotechnol. Res., 2015; cited in IDS) as applied to claims 1, 2, 5, 6, 9, 12, 14 and 15, and further in view of Kitamoto et al. (Journal of Oleo Science; Jan 2022). Regarding Claims 1, 2, 5, 6, 9, 12 and 14, the teachings of Ramin et al. and De Oliveira et al. are described supra. Ramin et al. teach that the composition can further comprise moisturizers (e.g. paragraph 0071). They do not teach the inclusion of mannosylerythritol lipids. This is made up for by the teachings of Kitamoto et al. Kitamoto et al. teach that mannosylerythritol lipids (MELs) show excellent moisturizing effects on human skin and hair, with comparable performance to natural ceramides (e.g. abstract). Kitamoto et al. teach that biosurfactants are attractive practical alternatives to chemical surfactants because they are effective ingredients for cosmetic and personal care products, due to their favorable attributes of lower toxicity, antimicrobial activity, skin compatibility, and protective and surface moisturizing effects (e.g. page 6, Section 6.1). Kitamoto et al. teach that the costs of ceramides are still high, due to their limited availability in plants or their complicated synthetic and purification processes. Also, they are hardly soluble in water; which makes handling them very difficult. Considering the high productivity of MELs and their interfacial properties, MELs will be a practical and low-cost replacement for ceramides (e.g. page 7, column 1). Regarding Claims 3 and 13, it would have been obvious to one of ordinary skill in the art at the time of filing to include the mannosylerythritol lipids (MELs) of Kitamoto et al. in the nail polish remover composition of Ramin et al. It would have been obvious to one of ordinary skill in the art to combine the elements as claimed by known methods with no change in their respective functions, and the combination yielding nothing more than predictable results. One of ordinary skill in the art would have predicted success as Ramin et al. teach the addition of moisturizing ingredients, and one of ordinary skill would have been motivated in order to provide the benefits of lower toxicity, antimicrobial activity, skin compatibility, and protective and surface moisturizing effects, at lower cost as taught by Kitamoto et al. Regarding Claim 4, neither the claim, nor the specification define “a fermentation broth”. However, De Oliveira et al. teach that SLP are produced from several microorganisms, which grow are known to grow in aqueous media, and Ramin et al. exemplify water in the compositions (i.e. a fermentation broth) (e.g. Example 1). Response to Arguments Applicant’s arguments with respect to claim(s) 1-6, 9 and 12-15 have been considered but are moot because the new ground of rejection does not rely on any reference applied in the prior rejection of record for any teaching or matter specifically challenged in the argument. Conclusion No claim is allowed. Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to NICOLE PLOURDE BABSON whose telephone number is (571)272-3055. The examiner can normally be reached M-Th 8-4:30; F 8-12:30. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, David Blanchard can be reached on 571-272-0827. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /NICOLE P BABSON/ Primary Examiner, Art Unit 1619
Read full office action

Prosecution Timeline

Apr 08, 2023
Application Filed
Oct 10, 2025
Non-Final Rejection — §103, §112
Dec 09, 2025
Response Filed
Jan 22, 2026
Final Rejection — §103, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
46%
Grant Probability
78%
With Interview (+31.8%)
3y 8m
Median Time to Grant
Moderate
PTA Risk
Based on 516 resolved cases by this examiner. Grant probability derived from career allow rate.

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