Prosecution Insights
Last updated: April 19, 2026
Application No. 18/253,171

Composition Containing Bifidobacterium Lactis and Human Milk Oligosaccharides and Application Thereof

Non-Final OA §102§112
Filed
May 16, 2023
Examiner
GANGLE, BRIAN J
Art Unit
1645
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Inner Mongolia Dairy Tech Res Institute Co. Ltd.
OA Round
1 (Non-Final)
76%
Grant Probability
Favorable
1-2
OA Rounds
2y 8m
To Grant
92%
With Interview

Examiner Intelligence

Grants 76% — above average
76%
Career Allow Rate
718 granted / 940 resolved
+16.4% vs TC avg
Strong +15% interview lift
Without
With
+15.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
28 currently pending
Career history
968
Total Applications
across all art units

Statute-Specific Performance

§101
4.5%
-35.5% vs TC avg
§103
15.0%
-25.0% vs TC avg
§102
23.0%
-17.0% vs TC avg
§112
36.6%
-3.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 940 resolved cases

Office Action

§102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Applicant’s election of Group II in the reply filed on 9/22/2025 is acknowledged. Because applicant did not distinctly and specifically point out the supposed errors in the restriction requirement, the election has been treated as an election without traverse (MPEP § 818.01(a)). Claims 1-4, 10, and 12-18 are pending. Claims 1-4, 10, and 17-18 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Claims 12-16 are currently under examination. Information Disclosure Statement The information disclosure statements filed on 7/19/2023 and 12/26/2024 have been considered. Signed copies are enclosed. Claim Objections Claims 12-16 are objected to because they are dependent on non-elected claims. Claims 14 and 16 are objected to because of the following informalities: Claims 14 and 16 contain the acronyms CFU and HMO. While acronyms are permissible shorthand in the claims, the first recitation of the term should include the full recitation followed by the acronym in parentheses. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (B) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 14 and 16 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor, or for pre-AIA the applicant regards as the invention. Regarding claim 14, the phrases "such as" and “particularly” render the claim indefinite because it is unclear whether the limitations following the phrase are part of the claimed invention. See MPEP § 2173.05(d). Claims 14 and 16 are rendered indefinite by the term “preferably”. Description of examples or preferences is properly set forth in the specification rather than the claims. The term "preferably" renders the claim indefinite because it is unclear whether the limitations following the term are part of the claimed invention. See MPEP § 2173.05(d). Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 12-16 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Buck et al (US Patent Application Publication 2012/0171165, 2012; IDS filed 7/19/2023). The instant claims are drawn to methods for or enhancing resistance of an organism to Staphylococcus aureus infection, improving innate immunity of an organism, and/or anti- aging comprising administering a composition comprising Bifidobacterium lactis and human milk oligosaccharides (HMOs). Buck et al disclose methods of administering nutritional compositions comprising HMOs and probiotics (see paragraph 0006). These compositions are administered to improve the immune system and help resist infection, among other benefits (see paragraph 0175). The probiotic strain can be B lactis HN019 (see paragraph 0126). The HMOs include 2’-fucosyllactose as well as 2'-fucosyllactose, 3'-fucosyllactose, lactose-N-tetraose, 3'- sialyllactose, and 6'-sialyllactose (see paragraph 0060). The nutritional composition can be in the form of an oral liquid, liquid or solid beverage, or infant formula powder (see paragraphs 0062-0071). It is noted that while S aureus infection is not specifically discussed, administration of the same product to the same population would necessarily cause the same outcome. Therefore, following the method steps of Buck et al would necessarily enhance resistance to S aureus infection, improve the innate immunity of the organism and improve anti-aging. Conclusion No claim is allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Brian J Gangle whose telephone number is (571)272-1181. The examiner can normally be reached M-F, 9-6:30. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Vanessa Ford can be reached at 571-272-0857. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRIAN GANGLE/ Primary Examiner, Art Unit 1645
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Prosecution Timeline

May 16, 2023
Application Filed
Nov 24, 2025
Non-Final Rejection — §102, §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
76%
Grant Probability
92%
With Interview (+15.4%)
2y 8m
Median Time to Grant
Low
PTA Risk
Based on 940 resolved cases by this examiner. Grant probability derived from career allow rate.

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