Prosecution Insights
Last updated: April 19, 2026
Application No. 18/254,058

SYSTEMS AND METHODS TO PREDICT AN INDIVIDUALS MICROBIOME STATUS AND PROVIDE PERSONALIZED RECOMMENDATIONS TO MAINTAIN OR IMPROVE THE MICROBIOME STATUS

Non-Final OA §102§103§112§DP
Filed
May 23, 2023
Examiner
O'HERN, BRENT T
Art Unit
1793
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Société des Produits Nestlé S.A.
OA Round
1 (Non-Final)
78%
Grant Probability
Favorable
1-2
OA Rounds
2y 9m
To Grant
98%
With Interview

Examiner Intelligence

Grants 78% — above average
78%
Career Allow Rate
1216 granted / 1560 resolved
+12.9% vs TC avg
Strong +20% interview lift
Without
With
+20.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 9m
Avg Prosecution
42 currently pending
Career history
1602
Total Applications
across all art units

Statute-Specific Performance

§101
0.2%
-39.8% vs TC avg
§103
41.2%
+1.2% vs TC avg
§102
14.6%
-25.4% vs TC avg
§112
37.9%
-2.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1560 resolved cases

Office Action

§102 §103 §112 §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Applicant’s election without traverse of Group I in the reply filed on 1/14/2026 is acknowledged. Specification The following guidelines illustrate the preferred layout for the specification of a utility application. These guidelines are suggested for the applicant’s use. Arrangement of the Specification As provided in 37 CFR 1.77(b), the specification of a utility application should include the following sections in order. Each of the lettered items should appear in upper case, without underlining or bold type, as a section heading. If no text follows the section heading, the phrase “Not Applicable” should follow the section heading: (a) TITLE OF THE INVENTION. (b) CROSS-REFERENCE TO RELATED APPLICATIONS. (c) STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT. (d) THE NAMES OF THE PARTIES TO A JOINT RESEARCH AGREEMENT. (e) INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A READ-ONLY OPTICAL DISC, AS A TEXT FILE OR AN XML FILE VIA THE PATENT ELECTRONIC SYSTEM. (f) STATEMENT REGARDING PRIOR DISCLOSURES BY THE INVENTOR OR A JOINT INVENTOR. (g) BACKGROUND OF THE INVENTION. (1) Field of the Invention. (2) Description of Related Art including information disclosed under 37 CFR 1.97 and 1.98. (h) BRIEF SUMMARY OF THE INVENTION. (i) BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S). (j) DETAILED DESCRIPTION OF THE INVENTION. (k) CLAIM OR CLAIMS (commencing on a separate sheet). (l) ABSTRACT OF THE DISCLOSURE (commencing on a separate sheet). (m) SEQUENCE LISTING. (See MPEP § 2422.03 and 37 CFR 1.821 - 1.825). A “Sequence Listing” is required on paper if the application discloses a nucleotide or amino acid sequence as defined in 37 CFR 1.821(a) and if the required “Sequence Listing” is not submitted as an electronic document either on read-only optical disc or as a text file via the patent electronic system. When there are drawings, there shall be a “brief description of the several views of the drawings” (See 37 C.F.R. 1.74.). The section heading “brief description of the several views of the drawings” as set forth in 37 C.F.R. 1.74 is missing. Please correct. Claim Objections Claim 6 is objected to because of the following informalities: a semicolon “;” is missing after the word “status” in line 13. Appropriate correction is required. Claim 6 is objected to because of the following informalities: a semicolon “;” is missing after the word “diabetes” in line 21. Appropriate correction is required. Claim 6 is objected to because of the following informalities: a period “.” Instead of a semicolon “;” is after the word “vaccine” in line 23. Appropriate correction is required. Claim 6 is objected to because of the following informalities: a semicolon “;” is missing after the word “status” in line 13. Appropriate correction is required. Claim 6 is objected to because of the following informalities: a semicolon “;” is missing after the word “diabetes” in line 21. Appropriate correction is required. Claim 6 is objected to because of the following informalities: a period “.” Instead of a semicolon “;” is after the word “vaccine” in line 23. Appropriate correction is required. Claim 7 is objected to because of the following informalities: a semicolon “;” is missing after the word “status” in line 13. Appropriate correction is required. Claim 7 is objected to because of the following informalities: a semicolon “;” is missing after the word “diabetes” in line 21. Appropriate correction is required. Claim 7 is objected to because of the following informalities: a period “.” Instead of a semicolon “;” is after the word “vaccine” in line 23. Appropriate correction is required. Claim 7 is objected to because of the following informalities: a semicolon “;” is missing after the word “status” in line 13. Appropriate correction is required. Claim 7 is objected to because of the following informalities: a semicolon “;” is missing after the word “diabetes” in line 21. Appropriate correction is required. Claim 7 is objected to because of the following informalities: a period “.” Instead of a semicolon “;” is after the word “vaccine” in line 23. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-8 and 10 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. The phrase “determining the gut microbiome status” in Claim 1, line 3 is vague and indefinite as it is unclear how “determining … status” is possible without taking a biological sample of material from a subject. It appears a person could be eating an excellent diet which may be indicative of a healthy microbiome, however, the person’s microbiome status may be poor due to unknown medical condition. Furthermore, the mere “determining” without carrying out any physical/biological step on a subject does appear to provide any status. Applicant is advised to consider setting forth specific method steps connecting “determining” to “status”. The phrase “providing recommendations … in said subject” in Claim 1, line 4 is vague and indefinite as it is unclear how recommendations further limit the method of “determining … status” as providing recommendations is something that may be done after one determines that one’s status is not desirable and needs to be corrected. Claim 2 recites the limitation "the microbiome activity" in line 2. There is insufficient antecedent basis for this limitation in the claim. Applicant is advised to consider earlier stating “microbiome activity". The phrase “determination of microbiome status is by questionnaire” in Claim 2, lines 1-2 is vague and indefinite as it is unclear how it is possible without taking a biological sample of material from a subject. It appears a person could be eating an excellent diet which may be indicative of a healthy microbiome, however, the person’s microbiome status may be poor due to unknown medical condition. The phrase “wherein said method is computer-implemented” in Claim 4, line 2 is vague and indefinite as it is unclear how determining status can be “computer-implemented” when determining status appears to require obtaining a biological sample. Claim 6 recites the limitation "the feature parameters" in line 2. There is insufficient antecedent basis for this limitation in the claim. Applicant is advised to consider earlier stating “feature parameters". Claim 6 recites the limitation "the location of exercise" in line 14. There is insufficient antecedent basis for this limitation in the claim. Applicant is advised to consider stating “location of exercise". Claim 7 recites the limitation "said feature parameters" in line 2. There is insufficient antecedent basis for this limitation in the claim. Applicant is advised to consider earlier stating “feature parameters". Claim 8 recites the limitation "a subject" in lines 3-4. There is insufficient antecedent basis for this limitation in the claim. Applicant is advised to consider stating “the subject". Claim 8 recites the limitation "the same geographic region" in line 6. There is insufficient antecedent basis for this limitation in the claim. Applicant is advised to consider stating “a same geographic region ". Clarification and/or correction required. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1-4, 6, 7, 8 and 10 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Dominianni et al., Sex, Body Mass Index, and Dietary Fiber Intake Influence the Human Gut Microbiome (2015). The claims are interpreted as being directed to a method for determining the gut microbiome status. Claim 1 is not interpreted as having any method steps as no biological sample is collected. Claim 1 is not interpreted as a method where anyone eats any food. Claim 2 is not interpreted as having any method steps as asking questions does provide status as there is no connection between asking questions and a status. Claim 4 is not interpreted as having any method steps as implementing a computer does not provide status. Claim 6 is not interpreted as having any method steps as asking questions does provide status as there is no connection between answering questions and a status. Claim 7 is not interpreted as having any method steps as asking questions does provide status as there is no connection between answering questions and a status. Claim 8 is not interpreted as having any method steps as no biological sample is collected. Claim 10 is not interpreted as having any method steps directed to the method for determining gut microbiome status as informing a subject is for a different method. Regarding Claims 1, 2, 4, 6, 7, 8 and 10, Dominianni (2015) teaches a method of determining the microbiome status including ethnicity (See Abs., p. 2, last paragraph to p. 3, first paragraph, FIG-4, Table 4 where diets with fiber are evaluated for determining status.). PNG media_image1.png 570 738 media_image1.png Greyscale PNG media_image2.png 658 736 media_image2.png Greyscale Regarding Claim 3, Dominianni (2015) teaches wherein a biological sample of a subject is taken to determine microbiome status (See p. 2, para. 3+.). Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claim(s) 5 is/are rejected under 35 U.S.C. 103 as being unpatentable over Dominianni et al., Sex, Body Mass Index, and Dietary Fiber Intake Influence the Human Gut Microbiome (2015). Regarding Claim 5, Dominianni (2015) teaches the method discussed above, however, fails to expressly disclose wherein said method involves evaluation of feature parameters related to gut microbiome status as Low, Medium or High. Applicant does not set forth any non-obvious unexpected results for selecting one status over another. It would have been foreseeable and obvious prior to the earliest effective filing date to select any subjective status, including the claimed scheme, one desires to evaluate status. The selection of status scheme would have been within the skill set of a person having ordinary skill in the art to provide a scheme for analyzing status. Double Patenting Claims 1 is provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claim 1 of copending Application No. 18/577,113 (reference application). Although the claims at issue are not identical, they are not patentably distinct from each other because neither claim 1 in this application or claim 1 in copending Application No. 18/577,113 teach any steps of determining the effects of eating any food. The claim in this application refers to determining status while application 18/577,113 effects of food on. The mere reference to food are not process steps and do not further limit the claims. This is a provisional nonstatutory double patenting rejection because the patentably indistinct claims have not in fact been patented. Claim 1 is provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claim 1 and 2 of copending Application No. 18/684,723 (reference application). Although the claims at issue are not identical, they are not patentably distinct from each other because neither claim 1 in this application or claims 1 and 2 in copending Application No. 18/684,723 teach any steps of determining the effects of eating any food. The claims in this application refer to The claim in this application refer to determining status while application 18/684,723 refers to types of polyphenols. The mere reference to fibers and polyphenols are not process steps and do not further limit the claims. This is a provisional nonstatutory double patenting rejection because the patentably indistinct claims have not in fact been patented. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to BRENT T O'HERN whose telephone number is (571)272-6385. The examiner can normally be reached M-Th 5:00 am - 3:30 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Emily Le can be reached at 571-272-0903. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRENT T O'HERN/ Primary Examiner, Art Unit 1793 January 17, 2026
Read full office action

Prosecution Timeline

May 23, 2023
Application Filed
Feb 15, 2026
Non-Final Rejection — §102, §103, §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
78%
Grant Probability
98%
With Interview (+20.0%)
2y 9m
Median Time to Grant
Low
PTA Risk
Based on 1560 resolved cases by this examiner. Grant probability derived from career allow rate.

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