DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Applicants' arguments, filed 12/10/2026, have been fully considered. Rejections and/or objections not reiterated from previous office actions are hereby withdrawn. The following rejections and/or objections are either reiterated or newly applied. They constitute the complete set presently being applied to the instant application.
Claim Rejections - 35 USC § 102
The text of those sections of Title 35, U.S. Code not included in this action can be found in a prior Office action.
Claim 65-69, 71, 72, 74 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Messersmith (US 20100028719).
Messersmith Teaches non-natural mimics of antimicrobial peptides, such as poly-N-substituted glycine (¶¶ 6 and 8) attached to TiO2 substrates via polymer, such as PEG, backfilling to form polymer brushes (¶ 44). Further teaches a brush like structure is expected when 2kDa PEG densities of 0.9 chains per nm2 are achieved, which suggests about 1nm between chains (¶ 55). The peptoids show activity against E. coli (¶¶ 28 and 31).
With regards to claim 67, he working embodiments include the use of PEG-2000 (¶ 39, Fig 11).
With regards to claim 68, glass substrates were also used (¶ 58).
With regards to claim 69, about 2nm can be construed to be 1 nm.
Claim Rejections - 35 USC § 103
The text of those sections of Title 35, U.S. Code not included in this action can be found in a prior Office action.
Claims 65-74 are rejected under 35 U.S.C. 103 as being unpatentable over Messersmith (US 20100028719).
Messersmith further teaches varying the density of the polymer (paragraph 55), therefore as a matter of optimizing the brush like structure, the density would be varied, causing variation in the spacing, form 3-20 nm.
Conclusion
Any inquiry concerning this communication or earlier communications from the examiner should be directed to BENJAMIN J PACKARD whose telephone number is (571)270-3440. The examiner can normally be reached Mon 2-6pm and Tues-Fri (9am-6pm + mid-day flex).
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/BENJAMIN J PACKARD/ Primary Examiner, Art Unit 1612