Last updated: July 17, 2026

Application No. 18/256,636

PDE4 DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS

Final Rejection

Filed

Jun 09, 2023

Priority

Dec 14, 2020 — provisional 63/124,877 +1 more

Examiner

MCDOWELL, BRIAN E

Art Unit

1624

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

BioTheryX Inc.

OA Round

2 (Final)

Interview Optional

— +30.4% interview lift. Examiner has a relatively high allowance rate (74%); +30.4% interview lift. A written response may suffice.

Based on 1122 resolved cases, 2023–2026

Examiner Intelligence

MCDOWELL, BRIAN E View full profile →

Grants 74% — above average

Career Allowance Rate

833 granted / 1122 resolved

+14.2% vs TC avg

Strong +30% interview lift

Without

With

+30.4%

Interview Lift

resolved cases with interview

Typical timeline

2y 2m

Avg Prosecution

59 currently pending

Career history

1176

Total Applications

across all art units

Statute-Specific Performance

§101

0.3%

-39.7% vs TC avg

§103

23.4%

-16.6% vs TC avg

§102

19.3%

-20.7% vs TC avg

§112

51.0%

+11.0% vs TC avg

Black line = Tech Center average estimate • Based on career data from 1122 resolved cases

Prosecution Timeline

Jun 09, 2023

Application Filed

Feb 17, 2026

Non-Final Rejection mailed

May 13, 2026

Response Filed

Jun 25, 2026

Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

18/323,939

Patent 12673920

INHIBITORS OF NLRP3 INFLAMMASOME

3y 1m to grant Granted Jul 07, 2026

17/629,344

Patent 12667101

PICOLINAMIDE DERIVATIVES USEFUL AS AGRICULTURAL FUNGICIDES

4y 5m to grant Granted Jun 30, 2026

18/692,791

Patent 12668586

AHR INHIBITOR, USE THEREOF, AND PREPARATION METHOD THEREFOR

2y 3m to grant Granted Jun 30, 2026

18/081,951

Patent 12661362

Methods for the Prevention and Treatment of Hearing Loss

3y 6m to grant Granted Jun 23, 2026

17/274,937

Patent 12653804

USES OF PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) INHIBITORS

5y 3m to grant Granted Jun 16, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

3-4

Expected OA Rounds

74%

Grant Probability

99%

With Interview (+30.4%)

2y 2m (~0m remaining)

Median Time to Grant

Moderate

PTA Risk

Based on 1122 resolved cases by this examiner. Grant probability derived from career allowance rate.