Prosecution Insights
Last updated: July 17, 2026
Application No. 18/261,504

ENCAPSULATION OF LIVE MICROORGANISMS FOR GASTROINTESTINALTARGETED DELIVERY

Final Rejection §103§112
Filed
Jul 14, 2023
Priority
Feb 19, 2021 — SG 10202101688R +1 more
Examiner
WASHVILLE, JEFFREY D
Art Unit
1766
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Nanyang Technological University
OA Round
2 (Final)
80%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
75%
With Interview

Examiner Intelligence

Grants 80% — above average
80%
Career Allowance Rate
1004 granted / 1257 resolved
+14.9% vs TC avg
Minimal -5% lift
Without
With
+-4.9%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
49 currently pending
Career history
1306
Total Applications
across all art units

Statute-Specific Performance

§101
0.1%
-39.9% vs TC avg
§103
86.3%
+46.3% vs TC avg
§102
6.5%
-33.5% vs TC avg
§112
3.1%
-36.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1257 resolved cases

Office Action

§103 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status 1. The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Amendment 2. The Applicants submitted claim amendments on 5/4/2026 in response to the office action mailed on 2/4/2026. The status of the claims are as follows. Claim Rejections - 35 USC § 112 3. The rejection of claims 2-3, 6 and 26 under 35 USC 112(b) have been withdrawn. Claim Rejections - 35 USC § 103 4. Claims 1-6, 8-11, 13, 15-17, 19, 22, 25-26 and 28 are rejected under 35 U.S.C. 103 as being unpatentable over (US 2022/0248738 A1) to Kyle et al. (hereinafter Kyle) in view of (US 2014/0302135 A1) to Durvasula et al. (hereinafter Durvasula) in further view of (US 2002/0160109 A1) to Yeo et al. (hereinafter Yeo). The above noted rejection is hereby maintained. Response to Arguments 5. Applicant's arguments filed 5/4/2026 have been fully considered but they are not persuasive. The Applicants arguments that “extra steps” are required is not persuasive as the requirement is that the prior art combination teaches the required steps of the method claimed and the term “comprising” does not exclude extra steps. Yeo stating that “spray drying is not commonly used” is not persuasive and this is not teaching away, just stating that it is uncommon, but known. The argument would be persuasive if claims 10-11 and 23 were incorporated into claim 1, which would be entered after final to advance prosecution and be allowed. Allowable Subject Matter 6. Claims 10-11 and 23 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. If the limitations of claims 10-11 and 23 were all added to claim 1 they would be considered allowable and entered after final. 7. The following is a statement of reasons for the indication of allowable subject matter: The specific microbial species and the period of viability if entered into claim 1 would be considered non-obviousness. Conclusion 8. THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). 9. A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. 10. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JEFFREY D WASHVILLE whose telephone number is (571)270-3262. The examiner can normally be reached M-F 9-5. 11. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. 12. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Randy Gulakowski can be reached at 571-270-3262. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. 13. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JEFFREY D WASHVILLE/Primary Examiner, Art Unit 1766
Read full office action

Prosecution Timeline

Jul 14, 2023
Application Filed
Feb 04, 2026
Non-Final Rejection mailed — §103, §112
May 04, 2026
Response Filed
Jun 26, 2026
Final Rejection mailed — §103, §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12679940
LAMINATED FILM AND FLEXIBLE DEVICE
3y 2m to grant Granted Jul 14, 2026
Patent 12674040
NANODIAMOND DISPERSION COMPOSITION
3y 2m to grant Granted Jul 07, 2026
Patent 12667643
SURGICAL ADHESIVES
3y 5m to grant Granted Jun 30, 2026
Patent 12661626
MICROSPHERE SYNTHESIS VIA ULTRASONIC SPRAY PYROLYSIS
3y 7m to grant Granted Jun 23, 2026
Patent 12661872
METHOD FOR MANUFACTURING GLASS SHEET COMPOSITE
3y 2m to grant Granted Jun 23, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
80%
Grant Probability
75%
With Interview (-4.9%)
2y 8m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1257 resolved cases by this examiner. Grant probability derived from career allowance rate.

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