Prosecution Insights
Last updated: April 19, 2026
Application No. 18/275,480

COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING SLEEP DISORDERS, CONTAINING, AS ACTIVE INGREDIENT, GUT MICROBIOTA OR EXTRACELLULAR VESICLES DERIVED THEREFROM

Non-Final OA §102§112
Filed
Aug 02, 2023
Examiner
MERCIER, MELISSA S
Art Unit
1615
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Kookmin University Industry Academy Cooperation Foundation
OA Round
2 (Non-Final)
72%
Grant Probability
Favorable
2-3
OA Rounds
2y 9m
To Grant
79%
With Interview

Examiner Intelligence

Grants 72% — above average
72%
Career Allow Rate
852 granted / 1181 resolved
+12.1% vs TC avg
Moderate +7% lift
Without
With
+6.9%
Interview Lift
resolved cases with interview
Typical timeline
2y 9m
Avg Prosecution
50 currently pending
Career history
1231
Total Applications
across all art units

Statute-Specific Performance

§101
1.1%
-38.9% vs TC avg
§103
41.2%
+1.2% vs TC avg
§102
17.1%
-22.9% vs TC avg
§112
25.3%
-14.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1181 resolved cases

Office Action

§102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Summary Receipt of the Preliminary Amendment dated October 22, 2025 is acknowledged. Claims 1, 3-16, and 19-20 are pending in this application. Claims 1, 4-6, and 19-20 have been amended. Claims 2 and 17-18 have been cancelled. All pending claims are under examination in this application. Withdrawn Rejections Claim Rejections - 35 USC § 112 The rejection of claims 1, 3-16, and 19-20 under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, because the specification, while being enabling for alleviating or treating sleep disorder, does not reasonably provide enablement for prevent sleep disorder has been withdrawn in view of the amendments to the claims to remove the term “preventing”. The rejection of Claims 4-6 under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention because the claims depend from cancelled claim 2 has been withdrawn in view of the amendment to the claims to change the dependency from 2 to 3. Claim Rejections - 35 USC § 102 The rejection of claims 1, 3-6, 12-13, 15-16, and 19-20 under 35 U.S.C. 102(a)(1) as being anticipated by Altaf et al. (US 2025/0114411) has been withdrawn in view of the submission of the interim copy of foreign priority document 10-2021-0015295. The rejection of claims 1, 3-6, 12-13, 15-16, and 19-20 under 35 U.S.C. 102(a)(1) as being anticipated by Altaf et al. (US 2023/0355689) has been withdrawn in view of the submission of the interim copy of foreign priority document 10-2021-0015295. Newly Applied Rejections The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. Claims 1, 15-16, and 19 are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Moiseyenko et al. (US 2024/0066074). Moiseyenko discloses probiotic treatments for neurodegenerative disorders and/or one or more symptoms of neurodegenerative disorders. Symptoms include sleep disruption (paragraph 0011). The method of treatment comprises administering a composition including Prevotella histicola (paragraph 0012). The compositions include a component of the isolated microbial organism. Such components may include, for example, bacterial outer membrane vesicles, bacterial capsules, bacterial cell wall, bacterial cell envelope, or other components of bacteria (paragraph 0041). Moiseyenko discloses oral administration of the composition (paragraph 0043). Regarding claim 15, the composition can be formulated as a pharmaceutical composition, nutraceutical composition, or a probiotic composition (paragraph 0043). Regarding claim 16, nutraceutical compositions include food stuffs (paragraph 0107). Regarding claim 19, according to Example 1, Prevotella histicola was obtained and cultured. Moiseyenka, therefore, anticipates the rejected claims. Claim Objections Claims 3-14 and 20 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. The closest prior art is that of Moiseyanka, as discussed above. Moisenyanka discloses sleep disturbances, as they relate to a neurological disorder, such as Parkinson’s. There is no disclosure of any specific sleep disorders as recited in claims 3-11. Moiseyanka additionally does not disclose extracellular vesicles. Conclusion Due to the new grounds of rejection presented in this office action, this action is made Non-Final. Any inquiry concerning this communication or earlier communications from the examiner should be directed to MELISSA S MERCIER whose telephone number is (571)272-9039. The examiner can normally be reached M-F 6:30 am to 4 pm EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Robert A Wax can be reached at 571-272-0623. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /MELISSA S MERCIER/ Primary Examiner, Art Unit 1615
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Prosecution Timeline

Aug 02, 2023
Application Filed
Jul 22, 2025
Non-Final Rejection — §102, §112
Oct 22, 2025
Response Filed
Jan 23, 2026
Non-Final Rejection — §102, §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
72%
Grant Probability
79%
With Interview (+6.9%)
2y 9m
Median Time to Grant
Moderate
PTA Risk
Based on 1181 resolved cases by this examiner. Grant probability derived from career allow rate.

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